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The map label for this gene is sdhB [H]

Identifier: 66045248

GI number: 66045248

Start: 2328697

End: 2329401

Strand: Direct

Name: sdhB [H]

Synonym: Psyr_2008

Alternate gene names: 66045248

Gene position: 2328697-2329401 (Clockwise)

Preceding gene: 66045247

Following gene: 66045249

Centisome position: 38.21

GC content: 57.45

Gene sequence:

>705_bases
ATGTTGCAAGTCAGTGTTTATCGTTACAACCCTGATCAGGACGCTGCACCATTCATGCAGGAGTTTCAGGTCGATACCGG
TGGCAAGGACCTGATGGTGCTGGACGTGCTGGCCTTGGTCAAAGAGCAGGATGAAGGCTTTTCGTACCGTCGCTCGTGCC
GTGAAGGCGTGTGCGGTTCCGACGGCATGAACATCAACGGCAAGAACGGCCTGGCCTGCATCACGCCGCTGTCGGCTGTC
GTTGCCAAGAACAAGCTGATCGTACGTCCGTTGCCGGGTTTGCCGGTTATCCGTGACCTGGTCGTCGATATGAGCATCTT
CTACAAGCAGTACGAGAAGGTGAAGCCGTTCCTGCAGAACGACACGCCGGCTCCGGCCATCGAACGTCTGCAAACGCCGG
AAGAGCGCGAAAAGCTCGATGGTCTGTACGAGTGCATCCTGTGCGCTTGCTGCTCGACTTCCTGCCCGTCCTTCTGGTGG
AACCCCGACAAGTTCCTGGGTCCTGCTGCACTGCTGCAAGCCTACCGTTTCCTGGCTGACAGCCGTGATACTCGCACCAG
TGAGCGTCTGGCTTCGCTTGATGATCCGTTCAGCGTATTCCGCTGCCGCGGCATCATGAACTGCGTCAACGTCTGTCCGA
AGGGCCTTAACCCAACCAAGGCTATCGGTCACGTGCGCAATATGTTGTTGCAGAACGGCGTCTGA

Upstream 100 bases:

>100_bases
CCCGGGTGACAAGAGTGTGACCAAACGTGCCGTGAACTTCTCGCCGAAAACTGTCCCGACTTTTGAACCGAAGATTCGGA
CTTATTAAGGGGTGACCGAT

Downstream 100 bases:

>100_bases
TTCATCGCTTTATCTGTTACACCGTTACACCGAAGTGGCTACGGCGCAGGCTTCAACCGGCGCCGTAGTTTTAACCTGAG
CAGTAGCTCGCAAAGCTGCG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLQVSVYRYNPDQDAAPFMQEFQVDTGGKDLMVLDVLALVKEQDEGFSYRRSCREGVCGSDGMNINGKNGLACITPLSAV
VAKNKLIVRPLPGLPVIRDLVVDMSIFYKQYEKVKPFLQNDTPAPAIERLQTPEEREKLDGLYECILCACCSTSCPSFWW
NPDKFLGPAALLQAYRFLADSRDTRTSERLASLDDPFSVFRCRGIMNCVNVCPKGLNPTKAIGHVRNMLLQNGV

Sequences:

>Translated_234_residues
MLQVSVYRYNPDQDAAPFMQEFQVDTGGKDLMVLDVLALVKEQDEGFSYRRSCREGVCGSDGMNINGKNGLACITPLSAV
VAKNKLIVRPLPGLPVIRDLVVDMSIFYKQYEKVKPFLQNDTPAPAIERLQTPEEREKLDGLYECILCACCSTSCPSFWW
NPDKFLGPAALLQAYRFLADSRDTRTSERLASLDDPFSVFRCRGIMNCVNVCPKGLNPTKAIGHVRNMLLQNGV
>Mature_234_residues
MLQVSVYRYNPDQDAAPFMQEFQVDTGGKDLMVLDVLALVKEQDEGFSYRRSCREGVCGSDGMNINGKNGLACITPLSAV
VAKNKLIVRPLPGLPVIRDLVVDMSIFYKQYEKVKPFLQNDTPAPAIERLQTPEEREKLDGLYECILCACCSTSCPSFWW
NPDKFLGPAALLQAYRFLADSRDTRTSERLASLDDPFSVFRCRGIMNCVNVCPKGLNPTKAIGHVRNMLLQNGV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=231, Percent_Identity=54.1125541125541, Blast_Score=257, Evalue=5e-69,
Organism=Escherichia coli, GI1786943, Length=233, Percent_Identity=69.5278969957081, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1790596, Length=223, Percent_Identity=38.1165919282511, Blast_Score=143, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17533915, Length=228, Percent_Identity=52.1929824561403, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322987, Length=227, Percent_Identity=52.863436123348, Blast_Score=250, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=53.2188841201717, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24643156, Length=230, Percent_Identity=51.304347826087, Blast_Score=232, Evalue=2e-61,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26136; Mature: 26136

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQVSVYRYNPDQDAAPFMQEFQVDTGGKDLMVLDVLALVKEQDEGFSYRRSCREGVCGS
CEEEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
DGMNINGKNGLACITPLSAVVAKNKLIVRPLPGLPVIRDLVVDMSIFYKQYEKVKPFLQN
CCCEECCCCCEEHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DTPAPAIERLQTPEEREKLDGLYECILCACCSTSCPSFWWNPDKFLGPAALLQAYRFLAD
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHC
SRDTRTSERLASLDDPFSVFRCRGIMNCVNVCPKGLNPTKAIGHVRNMLLQNGV
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLQVSVYRYNPDQDAAPFMQEFQVDTGGKDLMVLDVLALVKEQDEGFSYRRSCREGVCGS
CEEEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
DGMNINGKNGLACITPLSAVVAKNKLIVRPLPGLPVIRDLVVDMSIFYKQYEKVKPFLQN
CCCEECCCCCEEHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DTPAPAIERLQTPEEREKLDGLYECILCACCSTSCPSFWWNPDKFLGPAALLQAYRFLAD
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHC
SRDTRTSERLASLDDPFSVFRCRGIMNCVNVCPKGLNPTKAIGHVRNMLLQNGV
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]