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The map label for this gene is sdhA [H]

Identifier: 66045247

GI number: 66045247

Start: 2326912

End: 2328684

Strand: Direct

Name: sdhA [H]

Synonym: Psyr_2007

Alternate gene names: 66045247

Gene position: 2326912-2328684 (Clockwise)

Preceding gene: 66045246

Following gene: 66045248

Centisome position: 38.19

GC content: 59.9

Gene sequence:

>1773_bases
ATGGCTAACATTAATGCGCTTTCTTTCGACGCCATCATCATTGGTGGTGGCGGTGCCGGCATGCGCGCTGCGCTGCAGCT
CGCCCAGGGCGGTCACAAGACTGCCGTGGTCACCAAGGTCTTCCCGACCCGCTCGCATACCGTATCCGCCCAGGGTGGCA
TCACCTGTGCAATCGCTTCCGCCGATCCGAACGATGACTGGCGCTGGCACATGTACGATACCGTCAAGGGTTCCGACTAC
ATCGGTGACCAGGACGCTATCGAATACATGTGTTCCGTAGGTCCGGAAGCGGTCTTCGAGCTCGAGCACATGGGCCTGCC
GTTCTCCCGTACCGAGCAGGGCCGTATCTACCAGCGTCCGTTCGGTGGCCAGTCCAAGGACTTCGGCAAGGGCGGGCAGG
CTGCCCGTACCTGCGCTGCCGCCGACCGTACCGGTCACGCGCTGCTGCACACCCTGTATCAGGCCAACCTGAAGGCCGGC
ACTGTATTCCTCAACGAATACTATGCAGTGGATCTGGTGAAGAACAACGATGGCGCCTTTGTCGGCATCATCGCGATCTG
CATCGAGACGGGCGAAACCTCGTACATCCGCGCCAATGCAACCGTGCTGGCGACCGGCGGTGCAGGCCGTATCTACTCGT
CGACCACCAACGCCCTGATCAATACCGGTGACGGTATCGGCATGGCGCTGCGTGCCGGTGTGCCGGTTCAGGACATCGAA
ATGTGGCAGTTCCACCCGACCGGCATTGCCGGCGCAGGTGTACTGGTCACCGAAGGTTGCCGCGGTGAAGGCGGTTACCT
GATCAACAAGCACGGCGAGCGTTTCATGGAGCGTTACGCTCCGAACGCCAAGGACCTTGCCGGTCGTGACGTTGTGGCAC
GTTCCATGGTCAAGGAAATCATTGCCGGTAACGGCTGTGGTCCCGATGGCGATCATGTGATGCTCAAGCTCGATCACCTT
GGCGAAGAAGTGCTGCACAGCCGTCTGCCAGGCATCATGGAACTGTCCAAGACCTTCGCTCACGTCGATCCTGCGACCGC
GCCGATTCCTGTCGTACCGACCTGCCACTACATGATGGGCGGCGTTGCCACCAACATTCATGGCCAGGCGATCACTCAGG
ATGCGGCGGGCGTCGATCAGATCATTCCTGGTCTGTTCGCGGTCGGTGAAGTGGCTTGCGTATCGGTTCACGGCGCCAAC
CGTCTGGGCGGCAACTCGCTGCTCGATCTGGTGGTGTTCGGCCGCGCGGCGGGTATCCACCTGGAGCAGGCGCTGCGTGA
AGGCGTCGATTATGCGCGCGCTTCCGAGTCCGACATCGATGCTGCCCTCGCACGCCTTGCCGGCCTGAACGAGCGCACCA
CCGGTGAAGACGTTGCAACCCTGCGAAAAGAGCTGCAGAGCTGCATGCAGAACTACTTCGGTGTATTCCGTACTGGCGAA
TACATGCAGAAGGGTATTGCCCAGCTGGCTGATCTGCGCGTACGTATCGCCAACGTCAAGATCAACGACAAGAGCCAGGC
GTTCAACACCGCCCGTATCGAAGCGCTTGAACTGCAAAACCTGCTGGAAGTTGCCGAAGCCACGGCGATTGCCGCAGAGC
ATCGTAAAGAGTCCCGCGGCGCTCACGCTCGTGAAGACTTCGAAGATCGCGATGACGAGAACTGGTTGTGCCACACCCTG
TATTTCCCGGGTGACAAGAGTGTGACCAAACGTGCCGTGAACTTCTCGCCGAAAACTGTCCCGACTTTTGAACCGAAGAT
TCGGACTTATTAA

Upstream 100 bases:

>100_bases
GTCCGCCACTGCAGTACGTTTCCTGTTCCAGGCGGTATGCGGCGTTCTGATGTTCGCCTACTTCGTCTGGGGCGTGCAGA
TTCTTTGGGGTATCTGATCC

Downstream 100 bases:

>100_bases
GGGGTGACCGATATGTTGCAAGTCAGTGTTTATCGTTACAACCCTGATCAGGACGCTGCACCATTCATGCAGGAGTTTCA
GGTCGATACCGGTGGCAAGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MANINALSFDAIIIGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDY
IGDQDAIEYMCSVGPEAVFELEHMGLPFSRTEQGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKAG
TVFLNEYYAVDLVKNNDGAFVGIIAICIETGETSYIRANATVLATGGAGRIYSSTTNALINTGDGIGMALRAGVPVQDIE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEIIAGNGCGPDGDHVMLKLDHL
GEEVLHSRLPGIMELSKTFAHVDPATAPIPVVPTCHYMMGGVATNIHGQAITQDAAGVDQIIPGLFAVGEVACVSVHGAN
RLGGNSLLDLVVFGRAAGIHLEQALREGVDYARASESDIDAALARLAGLNERTTGEDVATLRKELQSCMQNYFGVFRTGE
YMQKGIAQLADLRVRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRGAHAREDFEDRDDENWLCHTL
YFPGDKSVTKRAVNFSPKTVPTFEPKIRTY

Sequences:

>Translated_590_residues
MANINALSFDAIIIGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDY
IGDQDAIEYMCSVGPEAVFELEHMGLPFSRTEQGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKAG
TVFLNEYYAVDLVKNNDGAFVGIIAICIETGETSYIRANATVLATGGAGRIYSSTTNALINTGDGIGMALRAGVPVQDIE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEIIAGNGCGPDGDHVMLKLDHL
GEEVLHSRLPGIMELSKTFAHVDPATAPIPVVPTCHYMMGGVATNIHGQAITQDAAGVDQIIPGLFAVGEVACVSVHGAN
RLGGNSLLDLVVFGRAAGIHLEQALREGVDYARASESDIDAALARLAGLNERTTGEDVATLRKELQSCMQNYFGVFRTGE
YMQKGIAQLADLRVRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRGAHAREDFEDRDDENWLCHTL
YFPGDKSVTKRAVNFSPKTVPTFEPKIRTY
>Mature_589_residues
ANINALSFDAIIIGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDYI
GDQDAIEYMCSVGPEAVFELEHMGLPFSRTEQGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKAGT
VFLNEYYAVDLVKNNDGAFVGIIAICIETGETSYIRANATVLATGGAGRIYSSTTNALINTGDGIGMALRAGVPVQDIEM
WQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEIIAGNGCGPDGDHVMLKLDHLG
EEVLHSRLPGIMELSKTFAHVDPATAPIPVVPTCHYMMGGVATNIHGQAITQDAAGVDQIIPGLFAVGEVACVSVHGANR
LGGNSLLDLVVFGRAAGIHLEQALREGVDYARASESDIDAALARLAGLNERTTGEDVATLRKELQSCMQNYFGVFRTGEY
MQKGIAQLADLRVRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRGAHAREDFEDRDDENWLCHTLY
FPGDKSVTKRAVNFSPKTVPTFEPKIRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=594, Percent_Identity=52.8619528619529, Blast_Score=585, Evalue=1e-167,
Organism=Escherichia coli, GI1786942, Length=583, Percent_Identity=70.4974271012007, Blast_Score=814, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=42.9809358752166, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1788928, Length=564, Percent_Identity=32.0921985815603, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=527, Percent_Identity=55.4079696394687, Blast_Score=576, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17505833, Length=596, Percent_Identity=49.1610738255034, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322416, Length=555, Percent_Identity=55.1351351351351, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322701, Length=591, Percent_Identity=51.9458544839255, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6320788, Length=485, Percent_Identity=26.1855670103093, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137288, Length=606, Percent_Identity=52.3102310231023, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24655642, Length=606, Percent_Identity=52.3102310231023, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24655647, Length=606, Percent_Identity=52.3102310231023, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24663005, Length=610, Percent_Identity=46.8852459016393, Blast_Score=538, Evalue=1e-153,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63338; Mature: 63207

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINALSFDAIIIGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIAS
CCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCEEEEEEC
ADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCSVGPEAVFELEHMGLPFSRTEQGRIYQRP
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECC
FGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKAGTVFLNEYYAVDLVKNNDGAF
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCE
VGIIAICIETGETSYIRANATVLATGGAGRIYSSTTNALINTGDGIGMALRAGVPVQDIE
EEEEEEEEECCCCCEEEECEEEEEECCCCCEECCCCCCEEECCCCCCEEEECCCCHHHCE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEI
EEEECCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
IAGNGCGPDGDHVMLKLDHLGEEVLHSRLPGIMELSKTFAHVDPATAPIPVVPTCHYMMG
HCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
GVATNIHGQAITQDAAGVDQIIPGLFAVGEVACVSVHGANRLGGNSLLDLVVFGRAAGIH
CEEECCCCCEECCHHCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCH
LEQALREGVDYARASESDIDAALARLAGLNERTTGEDVATLRKELQSCMQNYFGVFRTGE
HHHHHHHCCHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
YMQKGIAQLADLRVRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRG
HHHHHHHHHHHCEEEEEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AHAREDFEDRDDENWLCHTLYFPGDKSVTKRAVNFSPKTVPTFEPKIRTY
CCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANINALSFDAIIIGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIAS
CCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCEEEEEEC
ADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCSVGPEAVFELEHMGLPFSRTEQGRIYQRP
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECC
FGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKAGTVFLNEYYAVDLVKNNDGAF
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCE
VGIIAICIETGETSYIRANATVLATGGAGRIYSSTTNALINTGDGIGMALRAGVPVQDIE
EEEEEEEEECCCCCEEEECEEEEEECCCCCEECCCCCCEEECCCCCCEEEECCCCHHHCE
MWQFHPTGIAGAGVLVTEGCRGEGGYLINKHGERFMERYAPNAKDLAGRDVVARSMVKEI
EEEECCCCCCCCCEEEECCCCCCCCEEECCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
IAGNGCGPDGDHVMLKLDHLGEEVLHSRLPGIMELSKTFAHVDPATAPIPVVPTCHYMMG
HCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
GVATNIHGQAITQDAAGVDQIIPGLFAVGEVACVSVHGANRLGGNSLLDLVVFGRAAGIH
CEEECCCCCEECCHHCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCH
LEQALREGVDYARASESDIDAALARLAGLNERTTGEDVATLRKELQSCMQNYFGVFRTGE
HHHHHHHCCHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
YMQKGIAQLADLRVRIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRG
HHHHHHHHHHHCEEEEEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AHAREDFEDRDDENWLCHTLYFPGDKSVTKRAVNFSPKTVPTFEPKIRTY
CCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]