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The map label for this gene is uvrB [H]

Identifier: 66045214

GI number: 66045214

Start: 2290405

End: 2292420

Strand: Direct

Name: uvrB [H]

Synonym: Psyr_1974

Alternate gene names: 66045214

Gene position: 2290405-2292420 (Clockwise)

Preceding gene: 66045211

Following gene: 66045217

Centisome position: 37.59

GC content: 60.81

Gene sequence:

>2016_bases
ATGTCCGAGTTCCAGCTCGTTACCCGCTTTGAGCCAGCCGGCGATCAGCCCGAGGCCATTCGCCAACTGGTCGAAGGGAT
CGACGCAGGGCTCGCGCACCAGACCTTGCTCGGGGTGACCGGCTCGGGCAAGACGTTCAGCATCGCCAACGTGATTTCCC
AGATCAAGCGTCCGACGCTGGTGCTGGCACCGAACAAGACCCTGGCCGCGCAGTTGTATGGCGAATTCAAGGCGTTTTTC
CCGAACAACGCCGTGGAGTACTTCGTTTCCTACTACGACTACTACCAGCCCGAAGCCTATGTGCCGTCGTCCGACACCTT
CATCGAGAAGGATGCGTCGATCAACGACCACATCGAACAGATGCGCCTGTCGGCGACCAAGGCGCTGCTGGAGCGCAAGG
ATGCGATCATCGTCACCACGGTGTCGTGCATTTACGGTCTGGGCAGTCCGGAAACCTATCTGCGCATGGTCATGCACATC
GATCGCGGCGACAAACTCGATCAGCGTGCCTTGCTGCGCCGCCTGGCCGATCTGCAATACACCCGTAACGACATGGACTT
TGCCCGTGCGACCTTCCGGGTGCGCGGCGACGTGATCGACATCTACCCGGCCGAATCCGATCTGGAAGCGATCCGGGTCG
AACTGTTCGATGACGAGGTCGAGAGCCTGTCGGCGTTCGATCCGCTGACCGGCGAGGTGATCCGCAAGCTGCCGCGCTTC
ACCTTCTATCCGAAAAGCCACTACGTTACCCCGCGCGAAACGCTGATCGAGGCGATGGAAAACATCAAGGTCGAGCTGCA
GGAGCGCCTCGAATACCTGCGCAGCCAGAACAAACTGGTGGAAGCCCAGCGTCTTGAGCAACGCACCCGTTTCGATCTGG
AAATGATGCTCGAGCTGGGTTACTGCAACGGTATCGAAAACTACTCGCGCTACCTGTCGGGCCGTCCGTCCGGTGCGCCG
CCACCAACCTTGTTTGACTACCTGCCCCCCGATGCCTTGCTGGTGATCGACGAATCCCACGTCAGCGTGCCGCAGGTCGG
CGCGATGTACAAAGGTGACCGTTCGCGCAAGGAAACCCTGGTCGAGTACGGCTTCCGCCTGCCGTCGGCACTGGATAACC
GGCCGATGCGCTTCGATGAGTGGGAGGCGATCAGCCCGCAGACCATTTTCGTCTCGGCGACTCCGGGTAACTACGAGGCC
GAGCACGCTGGGCGTATCGTCGAGCAAGTGGTGCGTCCGACCGGCCTGGTGGACCCGCAGATCGAGATTCGTCCGGCGCT
GACTCAGGTCGACGACCTGCTGTCGGAAATTCACAAGCGTGCTGCGCTTGAGGAACGGGTACTGGTCACCACGCTGACCA
AACGCATGTCCGAGGATTTGACCGACTACCTGAGTGACCACGGCGTGCGGGTGCGCTACCTGCACTCGGACATCGATACG
GTGGAACGTGTCGAAATCATCCGTGACCTGCGACTGGGGACGTTCGACGTGCTGGTGGGCATCAACCTGCTGCGCGAAGG
TCTGGACATGCCTGAAGTGTCACTGGTGGCGATTCTCGATGCCGACAAGGAAGGCTTCCTGCGCTCCGACCGTTCGCTGA
TCCAGACCATTGGCCGGGCCGCACGGAACCTCAACGGCCGGGCGATTCTGTATGCCGACCGGATTACCGGCTCGATGGAG
CGCGCCATCGGCGAGACCGAGCGACGTCGCGAGAAGCAGATCGCTTTCAACCTGGAACACGGTATTACGCCCAAAGGCGT
ATTCAAGGACGTCGCCGACATCATGGAAGGCGCCACCGTGCCTGGCTCGCGCAGCAAGAAGCGCAAAGGCATGGCCAAAG
CCGCCGAAGAAAACGCCCGCTACGAGAACGAACTGCGCTCGCCGAGCGAGATCAACAAACGCATTCGCCAACTGGAAGAA
AAAATGTACCAACTGGCCCGCGACCTGGAATTCGAAGCCGCTGCGCAGATGCGCGACGAAATCGGCAAACTGCGCGAGCG
CTTGCTGGCGGTTTGA

Upstream 100 bases:

>100_bases
CGTCATGCGCCGACGAATATTTCCAGTTGTGCCGTCGAGGCGGTCAGGTCGCGGAGATTCACGCGAAGCCGTCACACGCG
CACCATTCAAGAGGTCAGTT

Downstream 100 bases:

>100_bases
TTGGCTAGCCGACTCTCGCGTCAATCCGCGTTGATCATCGTGCCAATGCTCTGCGTTGGCATGCCGTTGTCAAATCTCAA
TCCACCTGACAGAACTGCCG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSEFQLVTRFEPAGDQPEAIRQLVEGIDAGLAHQTLLGVTGSGKTFSIANVISQIKRPTLVLAPNKTLAAQLYGEFKAFF
PNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLRMVMHI
DRGDKLDQRALLRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRVELFDDEVESLSAFDPLTGEVIRKLPRF
TFYPKSHYVTPRETLIEAMENIKVELQERLEYLRSQNKLVEAQRLEQRTRFDLEMMLELGYCNGIENYSRYLSGRPSGAP
PPTLFDYLPPDALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEAISPQTIFVSATPGNYEA
EHAGRIVEQVVRPTGLVDPQIEIRPALTQVDDLLSEIHKRAALEERVLVTTLTKRMSEDLTDYLSDHGVRVRYLHSDIDT
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRAARNLNGRAILYADRITGSME
RAIGETERRREKQIAFNLEHGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENARYENELRSPSEINKRIRQLEE
KMYQLARDLEFEAAAQMRDEIGKLRERLLAV

Sequences:

>Translated_671_residues
MSEFQLVTRFEPAGDQPEAIRQLVEGIDAGLAHQTLLGVTGSGKTFSIANVISQIKRPTLVLAPNKTLAAQLYGEFKAFF
PNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLRMVMHI
DRGDKLDQRALLRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRVELFDDEVESLSAFDPLTGEVIRKLPRF
TFYPKSHYVTPRETLIEAMENIKVELQERLEYLRSQNKLVEAQRLEQRTRFDLEMMLELGYCNGIENYSRYLSGRPSGAP
PPTLFDYLPPDALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEAISPQTIFVSATPGNYEA
EHAGRIVEQVVRPTGLVDPQIEIRPALTQVDDLLSEIHKRAALEERVLVTTLTKRMSEDLTDYLSDHGVRVRYLHSDIDT
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRAARNLNGRAILYADRITGSME
RAIGETERRREKQIAFNLEHGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENARYENELRSPSEINKRIRQLEE
KMYQLARDLEFEAAAQMRDEIGKLRERLLAV
>Mature_670_residues
SEFQLVTRFEPAGDQPEAIRQLVEGIDAGLAHQTLLGVTGSGKTFSIANVISQIKRPTLVLAPNKTLAAQLYGEFKAFFP
NNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERKDAIIVTTVSCIYGLGSPETYLRMVMHID
RGDKLDQRALLRRLADLQYTRNDMDFARATFRVRGDVIDIYPAESDLEAIRVELFDDEVESLSAFDPLTGEVIRKLPRFT
FYPKSHYVTPRETLIEAMENIKVELQERLEYLRSQNKLVEAQRLEQRTRFDLEMMLELGYCNGIENYSRYLSGRPSGAPP
PTLFDYLPPDALLVIDESHVSVPQVGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFDEWEAISPQTIFVSATPGNYEAE
HAGRIVEQVVRPTGLVDPQIEIRPALTQVDDLLSEIHKRAALEERVLVTTLTKRMSEDLTDYLSDHGVRVRYLHSDIDTV
ERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRAARNLNGRAILYADRITGSMER
AIGETERRREKQIAFNLEHGITPKGVFKDVADIMEGATVPGSRSKKRKGMAKAAEENARYENELRSPSEINKRIRQLEEK
MYQLARDLEFEAAAQMRDEIGKLRERLLAV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=669, Percent_Identity=70.7025411061285, Blast_Score=961, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=22.4755700325733, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76358; Mature: 76227

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFQLVTRFEPAGDQPEAIRQLVEGIDAGLAHQTLLGVTGSGKTFSIANVISQIKRPTL
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHEEECCCCCEEHHHHHHHHHCCCEE
VLAPNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQ
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
MRLSATKALLERKDAIIVTTVSCIYGLGSPETYLRMVMHIDRGDKLDQRALLRRLADLQY
HHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TRNDMDFARATFRVRGDVIDIYPAESDLEAIRVELFDDEVESLSAFDPLTGEVIRKLPRF
CCCHHHHHHHHHEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
TFYPKSHYVTPRETLIEAMENIKVELQERLEYLRSQNKLVEAQRLEQRTRFDLEMMLELG
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YCNGIENYSRYLSGRPSGAPPPTLFDYLPPDALLVIDESHVSVPQVGAMYKGDRSRKETL
HCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCHHCCCCHHHHHH
VEYGFRLPSALDNRPMRFDEWEAISPQTIFVSATPGNYEAEHAGRIVEQVVRPTGLVDPQ
HHHHCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
IEIRPALTQVDDLLSEIHKRAALEERVLVTTLTKRMSEDLTDYLSDHGVRVRYLHSDIDT
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNLNGRAILYADRITGSMERAIGETERRREKQIAFNLEHGITPKGVFKDVADIMEGATV
HHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCC
PGSRSKKRKGMAKAAEENARYENELRSPSEINKRIRQLEEKMYQLARDLEFEAAAQMRDE
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IGKLRERLLAV
HHHHHHHHHCC
>Mature Secondary Structure 
SEFQLVTRFEPAGDQPEAIRQLVEGIDAGLAHQTLLGVTGSGKTFSIANVISQIKRPTL
CCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHEEECCCCCEEHHHHHHHHHCCCEE
VLAPNKTLAAQLYGEFKAFFPNNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQ
EECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
MRLSATKALLERKDAIIVTTVSCIYGLGSPETYLRMVMHIDRGDKLDQRALLRRLADLQY
HHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TRNDMDFARATFRVRGDVIDIYPAESDLEAIRVELFDDEVESLSAFDPLTGEVIRKLPRF
CCCHHHHHHHHHEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
TFYPKSHYVTPRETLIEAMENIKVELQERLEYLRSQNKLVEAQRLEQRTRFDLEMMLELG
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YCNGIENYSRYLSGRPSGAPPPTLFDYLPPDALLVIDESHVSVPQVGAMYKGDRSRKETL
HCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCHHCCCCHHHHHH
VEYGFRLPSALDNRPMRFDEWEAISPQTIFVSATPGNYEAEHAGRIVEQVVRPTGLVDPQ
HHHHCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
IEIRPALTQVDDLLSEIHKRAALEERVLVTTLTKRMSEDLTDYLSDHGVRVRYLHSDIDT
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
VERVEIIRDLRLGTFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARNLNGRAILYADRITGSMERAIGETERRREKQIAFNLEHGITPKGVFKDVADIMEGATV
HHCCCCCEEEEEHHHCCHHHHHHCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCC
PGSRSKKRKGMAKAAEENARYENELRSPSEINKRIRQLEEKMYQLARDLEFEAAAQMRDE
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IGKLRERLLAV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA