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The map label for this gene is psaA [H]

Identifier: 66045191

GI number: 66045191

Start: 2235967

End: 2236899

Strand: Reverse

Name: psaA [H]

Synonym: Psyr_1951

Alternate gene names: 66045191

Gene position: 2236899-2235967 (Counterclockwise)

Preceding gene: 66045192

Following gene: 66045190

Centisome position: 36.71

GC content: 62.38

Gene sequence:

>933_bases
ATGCCTATTTCACTCAAACGCCGTCCCTTGCTGCGCGTCCTGCTGACGGGGCTGATGGTCGCCCTGCTGGCGCCGTCCGG
CTTCGCCGCCGAACCGGCCAAACGCCTGCGCATCGGCATTACCCTGCACCCTTACTACAGCTACGTGAGCAATATCGTCG
GCGACAAGGCCGACGTCGTGCCGCTGATCCCGGCGGGCTTCAACCCGCATGCCTATGAGCCGCGCGCCGAGGACATCAAG
CGCATCGGTTCGCTGGACGTGATCGTACTCAACGGCGTCGGCCATGACGACTTTGCCGACCGCATGATCGCCGCCAGTGA
AACGCCGAACATCAAGACCATCGAGGCCAACGCCGATGTGCCGTTGCTGGCCGCCACCGGGGTGGCGGCGCGAGGTGCCG
GCAAAGTGGTCAACCCGCACACCTTCCTGTCGATCAGTGCGTCCATTGCGCAGGTCAACAATATCGCCCGCGAGCTGGGC
AAGCTGGACCCGGACAATGCCAAAACCTACACCGCCAATGCCCGTGCCTATGGCAAACGCCTGCGCCAGATGCGCGCCGA
CGCGCTCGCCAAACTGACCAAGGCACCCAATGCCGACCTGCGCGTGGCCACGGTGCATGCCGCCTACGACTACCTGCTGC
GCGAATTCGGCCTGGAAGTCACCGCCGTGGTTGAACCGGCGCATGGCATCGAGCCCAGCCCGAGTCAGTTGAAAAAAACC
ATCGACCAACTGCGTGAGCTGGATGTGAAAGTGATCTTCTCGGAGATGGACTTCCCGTCCACCTACGTCGAGACCATTCA
GCGTGAATCCGGAGTTCGGCTGTACCCGCTGTCGCACATTTCCTATGGCGAGTACACCGCCGACAAGTACGAAAAGGAAA
TGGCCGGCAACCTCGACACGGTGGTACGTGCCATTCAGGAGTCGGGCGCATGA

Upstream 100 bases:

>100_bases
ATTCAGGCTGGAAACAGGTCGTCGCGCAATTCGATGCTGGCGTGACCCGTCAGCACCCGCACTGAAACTCCGCATTCCTT
TGAAAGAAGACCGCTTGCCC

Downstream 100 bases:

>100_bases
CGGCTGCACAGCACCTCGACATCGTCAGCCAGGGGCCGGGCATCGAATTCAATCAGGTCAGCCTGACCCTCGGGCGCACC
ACGATTCTCGATCAGGTTCA

Product: periplasmic solute binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPISLKRRPLLRVLLTGLMVALLAPSGFAAEPAKRLRIGITLHPYYSYVSNIVGDKADVVPLIPAGFNPHAYEPRAEDIK
RIGSLDVIVLNGVGHDDFADRMIAASETPNIKTIEANADVPLLAATGVAARGAGKVVNPHTFLSISASIAQVNNIARELG
KLDPDNAKTYTANARAYGKRLRQMRADALAKLTKAPNADLRVATVHAAYDYLLREFGLEVTAVVEPAHGIEPSPSQLKKT
IDQLRELDVKVIFSEMDFPSTYVETIQRESGVRLYPLSHISYGEYTADKYEKEMAGNLDTVVRAIQESGA

Sequences:

>Translated_310_residues
MPISLKRRPLLRVLLTGLMVALLAPSGFAAEPAKRLRIGITLHPYYSYVSNIVGDKADVVPLIPAGFNPHAYEPRAEDIK
RIGSLDVIVLNGVGHDDFADRMIAASETPNIKTIEANADVPLLAATGVAARGAGKVVNPHTFLSISASIAQVNNIARELG
KLDPDNAKTYTANARAYGKRLRQMRADALAKLTKAPNADLRVATVHAAYDYLLREFGLEVTAVVEPAHGIEPSPSQLKKT
IDQLRELDVKVIFSEMDFPSTYVETIQRESGVRLYPLSHISYGEYTADKYEKEMAGNLDTVVRAIQESGA
>Mature_309_residues
PISLKRRPLLRVLLTGLMVALLAPSGFAAEPAKRLRIGITLHPYYSYVSNIVGDKADVVPLIPAGFNPHAYEPRAEDIKR
IGSLDVIVLNGVGHDDFADRMIAASETPNIKTIEANADVPLLAATGVAARGAGKVVNPHTFLSISASIAQVNNIARELGK
LDPDNAKTYTANARAYGKRLRQMRADALAKLTKAPNADLRVATVHAAYDYLLREFGLEVTAVVEPAHGIEPSPSQLKKTI
DQLRELDVKVIFSEMDFPSTYVETIQRESGVRLYPLSHISYGEYTADKYEKEMAGNLDTVVRAIQESGA

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 33745; Mature: 33614

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISLKRRPLLRVLLTGLMVALLAPSGFAAEPAKRLRIGITLHPYYSYVSNIVGDKADVV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECHHHHHHHHHHCCCCCEE
PLIPAGFNPHAYEPRAEDIKRIGSLDVIVLNGVGHDDFADRMIAASETPNIKTIEANADV
EEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCC
PLLAATGVAARGAGKVVNPHTFLSISASIAQVNNIARELGKLDPDNAKTYTANARAYGKR
CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHH
LRQMRADALAKLTKAPNADLRVATVHAAYDYLLREFGLEVTAVVEPAHGIEPSPSQLKKT
HHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHH
IDQLRELDVKVIFSEMDFPSTYVETIQRESGVRLYPLSHISYGEYTADKYEKEMAGNLDT
HHHHHHCCHHEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHH
VVRAIQESGA
HHHHHHHCCC
>Mature Secondary Structure 
PISLKRRPLLRVLLTGLMVALLAPSGFAAEPAKRLRIGITLHPYYSYVSNIVGDKADVV
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECHHHHHHHHHHCCCCCEE
PLIPAGFNPHAYEPRAEDIKRIGSLDVIVLNGVGHDDFADRMIAASETPNIKTIEANADV
EEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCC
PLLAATGVAARGAGKVVNPHTFLSISASIAQVNNIARELGKLDPDNAKTYTANARAYGKR
CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHH
LRQMRADALAKLTKAPNADLRVATVHAAYDYLLREFGLEVTAVVEPAHGIEPSPSQLKKT
HHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHH
IDQLRELDVKVIFSEMDFPSTYVETIQRESGVRLYPLSHISYGEYTADKYEKEMAGNLDT
HHHHHHCCHHEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHH
VVRAIQESGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8945574; 9767595; 11463916; 9379902 [H]