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The map label for this gene is yedX [C]

Identifier: 66045054

GI number: 66045054

Start: 2083497

End: 2083850

Strand: Direct

Name: yedX [C]

Synonym: Psyr_1810

Alternate gene names: 66045054

Gene position: 2083497-2083850 (Clockwise)

Preceding gene: 66045047

Following gene: 66045055

Centisome position: 34.19

GC content: 59.32

Gene sequence:

>354_bases
TTGGGAAAATTGACCACACACGTACTGGACGCCGCTCACGGCTGCCCGGGCAGCGCCATCCGCATCGAGTTGTACCGGGT
CGAAGACCAGCAGTTGCTGCACATTGTCAGTGCGCTTACCAACAGCGATGGGCGCTGCGATGCACCCCTGCTGCAGGGCG
AGGCCTATCAATCCGGCGTCTATCAATTGCACTTCAAGGCTGGCGATTATTACCGCGCGCGGGGCGTGGTCCTGAATGAG
CCCGCCTTTCTCGATGAGGTGGTGCTGCGCTTCGGCATTGATGCAGGTCAGGAACACTTTCATGTGCCGCTGTTAATCTC
GCCGTACAGCTACTCGACGTACAGGGGCAGCTGA

Upstream 100 bases:

>100_bases
ACAGGTTTTCCCGAAAGTGTCTTAATCGGTCGCAATCGCACGATGTAGAGCACTTCATTGGTGCACTGCGTCACCATGGC
CGGATGTGAGGAGTGAAGTT

Downstream 100 bases:

>100_bases
ATACCTCTTGCCCGCCCCACACTGCGGGCTTTTTTTTTGCGCGTATCTGCGCTTTTGCCCTGTGTACAATGCGCCAGTCC
CGACGCCGCCATCCACCTGC

Product: transthyretin

Products: NA

Alternate protein names: HIU hydrolase; HIUHase [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MGKLTTHVLDAAHGCPGSAIRIELYRVEDQQLLHIVSALTNSDGRCDAPLLQGEAYQSGVYQLHFKAGDYYRARGVVLNE
PAFLDEVVLRFGIDAGQEHFHVPLLISPYSYSTYRGS

Sequences:

>Translated_117_residues
MGKLTTHVLDAAHGCPGSAIRIELYRVEDQQLLHIVSALTNSDGRCDAPLLQGEAYQSGVYQLHFKAGDYYRARGVVLNE
PAFLDEVVLRFGIDAGQEHFHVPLLISPYSYSTYRGS
>Mature_116_residues
GKLTTHVLDAAHGCPGSAIRIELYRVEDQQLLHIVSALTNSDGRCDAPLLQGEAYQSGVYQLHFKAGDYYRARGVVLNEP
AFLDEVVLRFGIDAGQEHFHVPLLISPYSYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=114, Percent_Identity=37.719298245614, Blast_Score=84, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115532920, Length=116, Percent_Identity=33.6206896551724, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532922, Length=116, Percent_Identity=33.6206896551724, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534555, Length=116, Percent_Identity=33.6206896551724, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24652571, Length=117, Percent_Identity=35.8974358974359, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 12967; Mature: 12836

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLTTHVLDAAHGCPGSAIRIELYRVEDQQLLHIVSALTNSDGRCDAPLLQGEAYQSGV
CCCHHHHHHHHCCCCCCCEEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
YQLHFKAGDYYRARGVVLNEPAFLDEVVLRFGIDAGQEHFHVPLLISPYSYSTYRGS
EEEEEECCCEEEECCEEECCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GKLTTHVLDAAHGCPGSAIRIELYRVEDQQLLHIVSALTNSDGRCDAPLLQGEAYQSGV
CCHHHHHHHHCCCCCCCEEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
YQLHFKAGDYYRARGVVLNEPAFLDEVVLRFGIDAGQEHFHVPLLISPYSYSTYRGS
EEEEEECCCEEEECCEEECCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]