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The map label for this gene is crt [H]

Identifier: 66045015

GI number: 66045015

Start: 2014184

End: 2015281

Strand: Reverse

Name: crt [H]

Synonym: Psyr_1770

Alternate gene names: 66045015

Gene position: 2015281-2014184 (Counterclockwise)

Preceding gene: 66045018

Following gene: 66045014

Centisome position: 33.07

GC content: 63.02

Gene sequence:

>1098_bases
ATGAGTTCACAGGTTTCATCCGCCCGCCCGGTTCGACCTTCCGCCAGCCGGGATTCGATCGTTATCGACGTGCGTAACCA
CATCGGACACTTGACCCTCAATCGTCCGGAAGGCCTGAACGCAATCGATCTGGACATGGTCCGCACACTTCGCCAGCAAC
TTGACCGCTGGGCCGACGACCCCTCGGTTCATGCCGTGGTCCTGCGCGGCGCAGGCGGCAAGGCGTTCTGCGCCGGTGGC
GATATCCGTTCGCTGTATGAAAGCCACCAGAGCGGCCAGGATCTGCACCACACGTTTTTTGCCGAAGAGTACGAGCTGGA
CCTGGCCATTCACCGCTACCGCAAGCCGGTACTGGCCCTGATGGATGGCCTGGTGCTGGGCGGCGGCATGGGGCTGGTCC
AGGGAGCCGACCTGCGCGTGGTCACCGAACGCAGCCGCCTCGGCATGCCGGAGGTCGCCATCGGTTATTTCCCTGATGTC
GGCGGCAGTTATTTTCTCTCGCGGCTGCCCGGCGAACTCGGGACCTGGCTGGGCGTGACCGGGTCGCAGATCGGTGCTGC
CGACGCGTTGTACTGCGGCCTTGCCAACTGGTCCATGAACAGCGAACTGCTGCCGCGCCTCGACCACATGCTCGATCATC
TGAAATGGAAGTCGACCCCGCTCAAGGACCTGCAGGGTGCGCTGGCCAAGCTGGCGACCCAGCGTCTGCCCTCCCCTCCG
CTGGAATCCCTGCGCCACGCCATCGACCACTTTTTCGGGCTGCCGGATGTTCCCAGCATGCTTGAGCAACTGCAACAGGT
GGTCATCGGCGACACCCGCGAGTGGGCGCTGGATACCGTAGCCCGAATGAAAGCTCACTCACCGCTGGGCATGGCGGTGA
CCCTGGAAATGCTGCGCCGTGGCCGTCATCTGTCGCTGCCGGCCTGCTTCGCCATGGAGTTGCACCTGGACCGCCAATGG
TTCGAACGCGGTGACCTGATCGAGGGCATACGTGCGCTGATCATCGATAAAGACAAGAAGCCGCAATGGAAACACGCCAG
CGCGCAGGACGTCAGTGCCGCGCAGGTGCAGAGTTTCTTCAGCGGTCTGGAGAATTGA

Upstream 100 bases:

>100_bases
CTTAAACGCAGTTTTGCTTTGCACATTTGCGCTGCTACGATCTTCTGCGACGCTCGAATGCTCGAATAAGAAAAAAGCGC
AACCGAACAAGGAGTTCAGA

Downstream 100 bases:

>100_bases
GCCGTGCACGACCTTGAATTGAGTGAAGAGCAGGTAATGATTCGCGACATGGCGCGCGACTTTGCGCGTAATGAAATCGC
GCCGTATGCCCAGGCCTGGG

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSSQVSSARPVRPSASRDSIVIDVRNHIGHLTLNRPEGLNAIDLDMVRTLRQQLDRWADDPSVHAVVLRGAGGKAFCAGG
DIRSLYESHQSGQDLHHTFFAEEYELDLAIHRYRKPVLALMDGLVLGGGMGLVQGADLRVVTERSRLGMPEVAIGYFPDV
GGSYFLSRLPGELGTWLGVTGSQIGAADALYCGLANWSMNSELLPRLDHMLDHLKWKSTPLKDLQGALAKLATQRLPSPP
LESLRHAIDHFFGLPDVPSMLEQLQQVVIGDTREWALDTVARMKAHSPLGMAVTLEMLRRGRHLSLPACFAMELHLDRQW
FERGDLIEGIRALIIDKDKKPQWKHASAQDVSAAQVQSFFSGLEN

Sequences:

>Translated_365_residues
MSSQVSSARPVRPSASRDSIVIDVRNHIGHLTLNRPEGLNAIDLDMVRTLRQQLDRWADDPSVHAVVLRGAGGKAFCAGG
DIRSLYESHQSGQDLHHTFFAEEYELDLAIHRYRKPVLALMDGLVLGGGMGLVQGADLRVVTERSRLGMPEVAIGYFPDV
GGSYFLSRLPGELGTWLGVTGSQIGAADALYCGLANWSMNSELLPRLDHMLDHLKWKSTPLKDLQGALAKLATQRLPSPP
LESLRHAIDHFFGLPDVPSMLEQLQQVVIGDTREWALDTVARMKAHSPLGMAVTLEMLRRGRHLSLPACFAMELHLDRQW
FERGDLIEGIRALIIDKDKKPQWKHASAQDVSAAQVQSFFSGLEN
>Mature_364_residues
SSQVSSARPVRPSASRDSIVIDVRNHIGHLTLNRPEGLNAIDLDMVRTLRQQLDRWADDPSVHAVVLRGAGGKAFCAGGD
IRSLYESHQSGQDLHHTFFAEEYELDLAIHRYRKPVLALMDGLVLGGGMGLVQGADLRVVTERSRLGMPEVAIGYFPDVG
GSYFLSRLPGELGTWLGVTGSQIGAADALYCGLANWSMNSELLPRLDHMLDHLKWKSTPLKDLQGALAKLATQRLPSPPL
ESLRHAIDHFFGLPDVPSMLEQLQQVVIGDTREWALDTVARMKAHSPLGMAVTLEMLRRGRHLSLPACFAMELHLDRQWF
ERGDLIEGIRALIIDKDKKPQWKHASAQDVSAAQVQSFFSGLEN

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=359, Percent_Identity=36.4902506963788, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI37594469, Length=314, Percent_Identity=36.624203821656, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI194097323, Length=192, Percent_Identity=34.375, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI68989263, Length=239, Percent_Identity=28.8702928870293, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI31542718, Length=183, Percent_Identity=26.775956284153, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI70995211, Length=217, Percent_Identity=30.4147465437788, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI221142681, Length=175, Percent_Identity=33.1428571428571, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787659, Length=185, Percent_Identity=29.7297297297297, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788597, Length=209, Percent_Identity=28.2296650717703, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790281, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=357, Percent_Identity=36.4145658263305, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25144157, Length=357, Percent_Identity=36.4145658263305, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17536985, Length=208, Percent_Identity=30.2884615384615, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=171, Percent_Identity=30.4093567251462, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=176, Percent_Identity=30.6818181818182, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=170, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=209, Percent_Identity=28.2296650717703, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=168, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=203, Percent_Identity=32.512315270936, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28571730, Length=361, Percent_Identity=40.4432132963989, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI28571729, Length=361, Percent_Identity=40.4432132963989, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI20129971, Length=171, Percent_Identity=33.9181286549708, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24653477, Length=171, Percent_Identity=33.9181286549708, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19920382, Length=217, Percent_Identity=29.9539170506912, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24653139, Length=218, Percent_Identity=30.2752293577982, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922422, Length=205, Percent_Identity=25.8536585365854, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 40372; Mature: 40241

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQVSSARPVRPSASRDSIVIDVRNHIGHLTLNRPEGLNAIDLDMVRTLRQQLDRWADD
CCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHCCC
PSVHAVVLRGAGGKAFCAGGDIRSLYESHQSGQDLHHTFFAEEYELDLAIHRYRKPVLAL
CCEEEEEEECCCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDGLVLGGGMGLVQGADLRVVTERSRLGMPEVAIGYFPDVGGSYFLSRLPGELGTWLGVT
HHHHHHCCCCCCCCCCCEEEEECHHHCCCCCEEECCCCCCCHHHHHHHCCHHHHHHHCCC
GSQIGAADALYCGLANWSMNSELLPRLDHMLDHLKWKSTPLKDLQGALAKLATQRLPSPP
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCH
LESLRHAIDHFFGLPDVPSMLEQLQQVVIGDTREWALDTVARMKAHSPLGMAVTLEMLRR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GRHLSLPACFAMELHLDRQWFERGDLIEGIRALIIDKDKKPQWKHASAQDVSAAQVQSFF
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
SGLEN
HHCCC
>Mature Secondary Structure 
SSQVSSARPVRPSASRDSIVIDVRNHIGHLTLNRPEGLNAIDLDMVRTLRQQLDRWADD
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHHCCC
PSVHAVVLRGAGGKAFCAGGDIRSLYESHQSGQDLHHTFFAEEYELDLAIHRYRKPVLAL
CCEEEEEEECCCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDGLVLGGGMGLVQGADLRVVTERSRLGMPEVAIGYFPDVGGSYFLSRLPGELGTWLGVT
HHHHHHCCCCCCCCCCCEEEEECHHHCCCCCEEECCCCCCCHHHHHHHCCHHHHHHHCCC
GSQIGAADALYCGLANWSMNSELLPRLDHMLDHLKWKSTPLKDLQGALAKLATQRLPSPP
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCH
LESLRHAIDHFFGLPDVPSMLEQLQQVVIGDTREWALDTVARMKAHSPLGMAVTLEMLRR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHC
GRHLSLPACFAMELHLDRQWFERGDLIEGIRALIIDKDKKPQWKHASAQDVSAAQVQSFF
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
SGLEN
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]