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The map label for this gene is clpP

Identifier: 66044992

GI number: 66044992

Start: 1984783

End: 1985424

Strand: Direct

Name: clpP

Synonym: Psyr_1747

Alternate gene names: 66044992

Gene position: 1984783-1985424 (Clockwise)

Preceding gene: 66044991

Following gene: 66044993

Centisome position: 32.57

GC content: 57.17

Gene sequence:

>642_bases
ATGTCCCGCAATTCTTATATTCAGCAGAACTCTGACATCCAGGCCGCTGGCGGCCTGGTCCCGATGGTTATCGAGCAGTC
CGCCCGTGGCGAACGCGCCTATGACATCTATTCGCGCCTTCTCAAGGAGCGAGTCATCTTTATGGTTGGTCCGGTAGAGG
ACTACATGGCCAACCTTATCGCGGCGCAACTGCTTTTCCTTGAAGCGGAAAACCCGGACAAGGATATCCATCTCTACATC
AACTCGCCGGGCGGTTCGGTGACTGCTGGCATGTCGATCTACGACACCATGCAGTTCATCAAGCCGGACGTTTCGACCAT
CTGTATCGGTCAGGCCTGCAGCATGGGTGCATTCCTGCTGGCCGGCGGTGCAGAAGGCAAGCGTCATTGCCTGCCCAACT
CGCGGATGATGATTCACCAGCCGTTGGGCGGTTTCCAGGGTCAGGCGTCGGACATCGACATCCATGCCAAGGAAATCCTG
CACATTCGTCATCGCCTCAACTCGCTGCTGGCGCATCACACCGGCCAGAGCCTCGAAACCATCGAGCGCGATACCGAGCG
TGACAACTTCATGAGCGCAGAGCGTGCAGCCGAATACGGCCTGATCGACTCGGTGATCAACAAGCGTCAAATGCCTGCCT
AA

Upstream 100 bases:

>100_bases
GCCGACTGATTTCTCTTTTCGTGCGAAAACACCCACAAGCCAGCCTTCGCGCTGGCTTGTGCGTATTCAAGACTCGACTA
TTTGGGAGTGAATGCAGGAC

Downstream 100 bases:

>100_bases
GCGGCTCAAAATGTAGGGGGTCGGCACAACCGACCGCCTGCGGACTTGAAAAAGCCCGCAATAGCCTTCATCTTGTGTTG
CAAGCCTACCGGATTGGATC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MSRNSYIQQNSDIQAAGGLVPMVIEQSARGERAYDIYSRLLKERVIFMVGPVEDYMANLIAAQLLFLEAENPDKDIHLYI
NSPGGSVTAGMSIYDTMQFIKPDVSTICIGQACSMGAFLLAGGAEGKRHCLPNSRMMIHQPLGGFQGQASDIDIHAKEIL
HIRHRLNSLLAHHTGQSLETIERDTERDNFMSAERAAEYGLIDSVINKRQMPA

Sequences:

>Translated_213_residues
MSRNSYIQQNSDIQAAGGLVPMVIEQSARGERAYDIYSRLLKERVIFMVGPVEDYMANLIAAQLLFLEAENPDKDIHLYI
NSPGGSVTAGMSIYDTMQFIKPDVSTICIGQACSMGAFLLAGGAEGKRHCLPNSRMMIHQPLGGFQGQASDIDIHAKEIL
HIRHRLNSLLAHHTGQSLETIERDTERDNFMSAERAAEYGLIDSVINKRQMPA
>Mature_212_residues
SRNSYIQQNSDIQAAGGLVPMVIEQSARGERAYDIYSRLLKERVIFMVGPVEDYMANLIAAQLLFLEAENPDKDIHLYIN
SPGGSVTAGMSIYDTMQFIKPDVSTICIGQACSMGAFLLAGGAEGKRHCLPNSRMMIHQPLGGFQGQASDIDIHAKEILH
IRHRLNSLLAHHTGQSLETIERDTERDNFMSAERAAEYGLIDSVINKRQMPA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=57.4468085106383, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1786641, Length=205, Percent_Identity=72.6829268292683, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.8387096774194, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI20129427, Length=206, Percent_Identity=54.3689320388349, Blast_Score=240, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_PSE14 (Q48KZ0)

Other databases:

- EMBL:   CP000058
- RefSeq:   YP_273935.1
- ProteinModelPortal:   Q48KZ0
- SMR:   Q48KZ0
- STRING:   Q48KZ0
- GeneID:   3555975
- GenomeReviews:   CP000058_GR
- KEGG:   psp:PSPPH_1698
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   LPNASIM
- PhylomeDB:   Q48KZ0
- ProtClustDB:   PRK00277
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23578; Mature: 23447

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 114-114 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNSYIQQNSDIQAAGGLVPMVIEQSARGERAYDIYSRLLKERVIFMVGPVEDYMANLI
CCCCCCCCCCCCCCHHCCCHHEEHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHH
AAQLLFLEAENPDKDIHLYINSPGGSVTAGMSIYDTMQFIKPDVSTICIGQACSMGAFLL
HHHHHHEECCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCHHHEECCCHHCCCCEEE
AGGAEGKRHCLPNSRMMIHQPLGGFQGQASDIDIHAKEILHIRHRLNSLLAHHTGQSLET
ECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
IERDTERDNFMSAERAAEYGLIDSVINKRQMPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRNSYIQQNSDIQAAGGLVPMVIEQSARGERAYDIYSRLLKERVIFMVGPVEDYMANLI
CCCCCCCCCCCCCHHCCCHHEEHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHH
AAQLLFLEAENPDKDIHLYINSPGGSVTAGMSIYDTMQFIKPDVSTICIGQACSMGAFLL
HHHHHHEECCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCHHHEECCCHHCCCCEEE
AGGAEGKRHCLPNSRMMIHQPLGGFQGQASDIDIHAKEILHIRHRLNSLLAHHTGQSLET
ECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
IERDTERDNFMSAERAAEYGLIDSVINKRQMPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA