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The map label for this gene is fsr [H]

Identifier: 66044926

GI number: 66044926

Start: 1888864

End: 1890072

Strand: Direct

Name: fsr [H]

Synonym: Psyr_1681

Alternate gene names: 66044926

Gene position: 1888864-1890072 (Clockwise)

Preceding gene: 66044922

Following gene: 66044927

Centisome position: 31.0

GC content: 61.46

Gene sequence:

>1209_bases
ATGGCGACCAGTGCTCCGCCCGCGACGGCGAAGGCCTCGACCACCCCTCAAGCCAGCCCGCTGGTGATGCGCATCATCGG
TGCTGTTGCCCTCGCGCACCTGGTCAACGACCTGATTCAAGCCATCCTCCCGTCGATCTACCCGATGCTCAAGGCCAGCT
ACGACCTGAGCTTCACCCAGATCGGCCTGATTACCCTGACATTTCAGATCACAGCCTCGCTGCTGCAGCCCTGGGTCGGT
TATTACACTGACCGCCATCCCAACCCGCTGGTACTGCCCGTCGGATCGATCTGCACGCTGATCGGCATCGTCATGATGTC
GATGGTCGGCAGTTTCCCCTTGATCCTGCTGGCCGCCGCGCTGATCGGCATCGGCTCGTCAACGTTCCACCCGGAAGCCT
CGCGTATCGCGCGGCTGGCCTCCGGTGGTCGTTACGGGCTCGCGCAATCGACCTTTCAGGTCGGCGGCAACACAGGCACG
GCATTCGGACCGTTGCTGGCGGCGGCGATCATCATCCCGTTCGGCCAGGGCAATGTCGCCTGGATCGGCCTGTTTGCGTT
GTTCTCGCTGGGGCTGCTGTATGCGATCAGCCGCTGGTATCGCACGCACCTCAACCTGTTCAAGCTCAAGGCCGGTCAGG
CAGCCACTCATGGTCTGTCCAGAAAACGCGTGATTGCCTCGTTGGCAGTGCTGGCGTTCCTGGTGTTTTCCAAGTTCTTC
TACATGACCAGCCTGACCAGCTATTTCACCTTCTACCTGATCGAGAAATTTGGTCTGTCGGTCGCCAGCTCGCAGTTGCA
CCTGTTCCTGTTTCTGGGCGCCGTGGCGGCGGGGACCTTTTTCGGCGGGCCGATCGGTGACCGCATTGGCCGCAAGGCGG
TGATCTGGTTCTCGATTCTTGGTGCCGCGCCGTTCACCCTGGCGCTGCCCTATGCGGATCTGTTCTGGACCAGCGTACTC
AGTGTGATCATTGGCTTCGTCCTGGCCTCGGCGTTTTCCGCCATCGTGGTCTACGCCCAGGAGCTGGTGCCTGGCAACGT
GGGCATGATCGCCGGGCTGTTCTTCGGCCTGATGTTCGGCTTCGGCGGCATTGGCGCTGCCTTGCTCGGTTATCTGGCTG
ACAGCCACGGCATCCTGTTCGTCTACACGCTGTGCTCGTACCTGCCGCTGCTCGGTATCCTCGCGATTCTTCTGCCTCGG
ACCAAATAA

Upstream 100 bases:

>100_bases
TCGCCCCGAAAAATGGCACATTGGCGCGCCCCGGTACGCGTGACACATCTTGTAATCATTCGTACCGGGCGGCCCGCGAA
CCCTTTTACGGATAAATACC

Downstream 100 bases:

>100_bases
TGCTGATAGCAACGCTGATTTTCCTGTTCACCATCACGCTGGTCATCTGGCAACCCAAGGGCCTGGGCGTAGGCTGGAGT
GCCGTATTGGGGGCAATTCT

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MATSAPPATAKASTTPQASPLVMRIIGAVALAHLVNDLIQAILPSIYPMLKASYDLSFTQIGLITLTFQITASLLQPWVG
YYTDRHPNPLVLPVGSICTLIGIVMMSMVGSFPLILLAAALIGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNTGT
AFGPLLAAAIIIPFGQGNVAWIGLFALFSLGLLYAISRWYRTHLNLFKLKAGQAATHGLSRKRVIASLAVLAFLVFSKFF
YMTSLTSYFTFYLIEKFGLSVASSQLHLFLFLGAVAAGTFFGGPIGDRIGRKAVIWFSILGAAPFTLALPYADLFWTSVL
SVIIGFVLASAFSAIVVYAQELVPGNVGMIAGLFFGLMFGFGGIGAALLGYLADSHGILFVYTLCSYLPLLGILAILLPR
TK

Sequences:

>Translated_402_residues
MATSAPPATAKASTTPQASPLVMRIIGAVALAHLVNDLIQAILPSIYPMLKASYDLSFTQIGLITLTFQITASLLQPWVG
YYTDRHPNPLVLPVGSICTLIGIVMMSMVGSFPLILLAAALIGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNTGT
AFGPLLAAAIIIPFGQGNVAWIGLFALFSLGLLYAISRWYRTHLNLFKLKAGQAATHGLSRKRVIASLAVLAFLVFSKFF
YMTSLTSYFTFYLIEKFGLSVASSQLHLFLFLGAVAAGTFFGGPIGDRIGRKAVIWFSILGAAPFTLALPYADLFWTSVL
SVIIGFVLASAFSAIVVYAQELVPGNVGMIAGLFFGLMFGFGGIGAALLGYLADSHGILFVYTLCSYLPLLGILAILLPR
TK
>Mature_401_residues
ATSAPPATAKASTTPQASPLVMRIIGAVALAHLVNDLIQAILPSIYPMLKASYDLSFTQIGLITLTFQITASLLQPWVGY
YTDRHPNPLVLPVGSICTLIGIVMMSMVGSFPLILLAAALIGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNTGTA
FGPLLAAAIIIPFGQGNVAWIGLFALFSLGLLYAISRWYRTHLNLFKLKAGQAATHGLSRKRVIASLAVLAFLVFSKFFY
MTSLTSYFTFYLIEKFGLSVASSQLHLFLFLGAVAAGTFFGGPIGDRIGRKAVIWFSILGAAPFTLALPYADLFWTSVLS
VIIGFVLASAFSAIVVYAQELVPGNVGMIAGLFFGLMFGFGGIGAALLGYLADSHGILFVYTLCSYLPLLGILAILLPRT
K

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=397, Percent_Identity=58.6901763224181, Blast_Score=440, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42684; Mature: 42553

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSAPPATAKASTTPQASPLVMRIIGAVALAHLVNDLIQAILPSIYPMLKASYDLSFTQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IGLITLTFQITASLLQPWVGYYTDRHPNPLVLPVGSICTLIGIVMMSMVGSFPLILLAAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHH
LIGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNTGTAFGPLLAAAIIIPFGQGNVA
HHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHH
WIGLFALFSLGLLYAISRWYRTHLNLFKLKAGQAATHGLSRKRVIASLAVLAFLVFSKFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHH
YMTSLTSYFTFYLIEKFGLSVASSQLHLFLFLGAVAAGTFFGGPIGDRIGRKAVIWFSIL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
GAAPFTLALPYADLFWTSVLSVIIGFVLASAFSAIVVYAQELVPGNVGMIAGLFFGLMFG
HCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FGGIGAALLGYLADSHGILFVYTLCSYLPLLGILAILLPRTK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATSAPPATAKASTTPQASPLVMRIIGAVALAHLVNDLIQAILPSIYPMLKASYDLSFTQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IGLITLTFQITASLLQPWVGYYTDRHPNPLVLPVGSICTLIGIVMMSMVGSFPLILLAAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHH
LIGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNTGTAFGPLLAAAIIIPFGQGNVA
HHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHH
WIGLFALFSLGLLYAISRWYRTHLNLFKLKAGQAATHGLSRKRVIASLAVLAFLVFSKFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHH
YMTSLTSYFTFYLIEKFGLSVASSQLHLFLFLGAVAAGTFFGGPIGDRIGRKAVIWFSIL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
GAAPFTLALPYADLFWTSVLSVIIGFVLASAFSAIVVYAQELVPGNVGMIAGLFFGLMFG
HCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FGGIGAALLGYLADSHGILFVYTLCSYLPLLGILAILLPRTK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]