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The map label for this gene is fabF [H]

Identifier: 66044894

GI number: 66044894

Start: 1853805

End: 1855049

Strand: Direct

Name: fabF [H]

Synonym: Psyr_1649

Alternate gene names: 66044894

Gene position: 1853805-1855049 (Clockwise)

Preceding gene: 66044893

Following gene: 66044895

Centisome position: 30.42

GC content: 61.37

Gene sequence:

>1245_bases
GTGTCGCGTAGACGCGTCGTGGTCACCGGGATGGGCATGCTTTCGCCACTGGGCAATGACGTGCCCAGCAGTTGGCAAGG
CATTCTGGCGGGCCGCAGTGGCATTGGCCTTATCGAGCACACGGACTTGTCAGCCTTCACCACCCGCTTCGGCGGCTCGG
TCAAGGGTTTCAACGTCGAAGAATACCTCGCGCCCAAAGAAGCGCGCCGCCTCGATCTCTTTATTCAGTATGGCCTTGCG
GCCAGCTTTCAGGCCGTGCGTAATGCAGGCCTCGAAGTCACTGATGCAAACCGTGAGCGCATCGGCGTTGCCATGGGGTC
GGGCATCGGTGGTCTGACCAATATCGAAAACAGCAGTCGTCTGCTGCACGAGCAGGGTCCTGGACGGATTTCGCCGTTCT
TCGTTCCTGGCTCGATCATCAATATGATTTCCGGTTTCCTGTCGATCCACCTGGGCGCACAGGGACCCAATTACTCCATC
GCGACGGCTTGCACGACTGCAACCCACTGCATCGGCATGGCGGCTCGCAACATCGCCTATGACGAAGCGGACGTGATGAT
CGCCGGTGGCGCTGAAATGGCCGCCTGTGGACTCGGTCTGGGCGGCTTCGGTGCAGCGCGTGCGCTGTCGACCCGCAACG
ATGACCCGACCCGCGCCAGTCGCCCCTGGGACAAGGGCCGTGATGGCTTTGTCCTGTCCGACGGTGCCGGTGCCATGGTG
CTCGAAGAGCTTGAGCACGCCAAGGCGCGTGGCGCGACCATTTATGCAGAGCTGGTCGGGTTCGGCATGAGCGGCGACGC
TTATCACATGACTTCGCCACCTGATGACGGCGCCGGTGCTGCACGCTGCATCGTCAATGCGTTGCGTGATGCCAAGGTCA
ATCCCGATCAGGTGCAGTACATCAACGCACACGGTACGTCGACGCCTGCAGGCGATCTGGCCGAAGCTTCTGCGATCAAG
TCGGTATTCGGTGATCACGCCTACAAGCTGGCAGTCAGTTCGACCAAGTCGATGACCGGCCACCTGCTGGGCGCCGCCGG
TGCTGTCGAAGCGATCTTCAGCGTCCTGGCAATGGTTGATCAGGTGGCTCCGCCGACCATCAACCTGGATGAGCCAAGCG
AAGGCTGCGATCTGGACTTCGTGCCTCACGAAGCGCGCCGCATGCCGATCGACGTCGTTCTGTCGAACTCCTTCGGCTTT
GGTGGCACCAACGGCTCGCTGGTATTCCGTCGGTTCGCCGAGTAA

Upstream 100 bases:

>100_bases
GACTGCTGTCACGGGAAAACCGCACTGCTTTAACCGGCGTGCGGTTTTTTCTTTAAAAAACGCTGTGATTGTTCCGTAAA
CAAGAGAGAAGGAGAGTCCT

Downstream 100 bases:

>100_bases
TGCCCGACTGGGTCGATGGCTGCCCCGCAGACGCCTTGTCCCTCAAGGACCGAGGGCTGGCCTACGGCGATGGACTGTTT
GAAACCATCGTCGTCAAGGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSRRRVVVTGMGMLSPLGNDVPSSWQGILAGRSGIGLIEHTDLSAFTTRFGGSVKGFNVEEYLAPKEARRLDLFIQYGLA
ASFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIENSSRLLHEQGPGRISPFFVPGSIINMISGFLSIHLGAQGPNYSI
ATACTTATHCIGMAARNIAYDEADVMIAGGAEMAACGLGLGGFGAARALSTRNDDPTRASRPWDKGRDGFVLSDGAGAMV
LEELEHAKARGATIYAELVGFGMSGDAYHMTSPPDDGAGAARCIVNALRDAKVNPDQVQYINAHGTSTPAGDLAEASAIK
SVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAMVDQVAPPTINLDEPSEGCDLDFVPHEARRMPIDVVLSNSFGF
GGTNGSLVFRRFAE

Sequences:

>Translated_414_residues
MSRRRVVVTGMGMLSPLGNDVPSSWQGILAGRSGIGLIEHTDLSAFTTRFGGSVKGFNVEEYLAPKEARRLDLFIQYGLA
ASFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIENSSRLLHEQGPGRISPFFVPGSIINMISGFLSIHLGAQGPNYSI
ATACTTATHCIGMAARNIAYDEADVMIAGGAEMAACGLGLGGFGAARALSTRNDDPTRASRPWDKGRDGFVLSDGAGAMV
LEELEHAKARGATIYAELVGFGMSGDAYHMTSPPDDGAGAARCIVNALRDAKVNPDQVQYINAHGTSTPAGDLAEASAIK
SVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAMVDQVAPPTINLDEPSEGCDLDFVPHEARRMPIDVVLSNSFGF
GGTNGSLVFRRFAE
>Mature_413_residues
SRRRVVVTGMGMLSPLGNDVPSSWQGILAGRSGIGLIEHTDLSAFTTRFGGSVKGFNVEEYLAPKEARRLDLFIQYGLAA
SFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIENSSRLLHEQGPGRISPFFVPGSIINMISGFLSIHLGAQGPNYSIA
TACTTATHCIGMAARNIAYDEADVMIAGGAEMAACGLGLGGFGAARALSTRNDDPTRASRPWDKGRDGFVLSDGAGAMVL
EELEHAKARGATIYAELVGFGMSGDAYHMTSPPDDGAGAARCIVNALRDAKVNPDQVQYINAHGTSTPAGDLAEASAIKS
VFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAMVDQVAPPTINLDEPSEGCDLDFVPHEARRMPIDVVLSNSFGFG
GTNGSLVFRRFAE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=44.8687350835322, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI223972627, Length=171, Percent_Identity=53.2163742690059, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=23.3256351039261, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=65.6174334140436, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=39.0361445783133, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=38.7409200968523, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=44.4015444015444, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=26.2430939226519, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=416, Percent_Identity=23.5576923076923, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=37.8619153674833, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=42.7553444180523, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI19920632, Length=405, Percent_Identity=25.4320987654321, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221330659, Length=405, Percent_Identity=25.4320987654321, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581345, Length=418, Percent_Identity=23.6842105263158, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43270; Mature: 43139

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGMGMLSPLGNDVPSSWQGILAGRSGIGLIEHTDLSAFTTRFGGSVKGFNVE
CCCCEEEEECCCHHCCCCCCCCCCHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCCCHH
EYLAPKEARRLDLFIQYGLAASFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIENSSR
HHHCCHHHHHEEEEEECCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCCCHH
LLHEQGPGRISPFFVPGSIINMISGFLSIHLGAQGPNYSIATACTTATHCIGMAARNIAY
HHHHCCCCCCCCEECCHHHHHHHHHHHEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCC
DEADVMIAGGAEMAACGLGLGGFGAARALSTRNDDPTRASRPWDKGRDGFVLSDGAGAMV
CCCCEEEECCCHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
LEELEHAKARGATIYAELVGFGMSGDAYHMTSPPDDGAGAARCIVNALRDAKVNPDQVQY
HHHHHHHHHCCCEEEEHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
INAHGTSTPAGDLAEASAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAMVD
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVAPPTINLDEPSEGCDLDFVPHEARRMPIDVVLSNSFGFGGTNGSLVFRRFAE
HCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SRRRVVVTGMGMLSPLGNDVPSSWQGILAGRSGIGLIEHTDLSAFTTRFGGSVKGFNVE
CCCEEEEECCCHHCCCCCCCCCCHHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCCCHH
EYLAPKEARRLDLFIQYGLAASFQAVRNAGLEVTDANRERIGVAMGSGIGGLTNIENSSR
HHHCCHHHHHEEEEEECCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCCCHH
LLHEQGPGRISPFFVPGSIINMISGFLSIHLGAQGPNYSIATACTTATHCIGMAARNIAY
HHHHCCCCCCCCEECCHHHHHHHHHHHEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCC
DEADVMIAGGAEMAACGLGLGGFGAARALSTRNDDPTRASRPWDKGRDGFVLSDGAGAMV
CCCCEEEECCCHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
LEELEHAKARGATIYAELVGFGMSGDAYHMTSPPDDGAGAARCIVNALRDAKVNPDQVQY
HHHHHHHHHCCCEEEEHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
INAHGTSTPAGDLAEASAIKSVFGDHAYKLAVSSTKSMTGHLLGAAGAVEAIFSVLAMVD
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVAPPTINLDEPSEGCDLDFVPHEARRMPIDVVLSNSFGFGGTNGSLVFRRFAE
HCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]