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The map label for this gene is nhaA [H]

Identifier: 66044886

GI number: 66044886

Start: 1847951

End: 1848949

Strand: Direct

Name: nhaA [H]

Synonym: Psyr_1641

Alternate gene names: 66044886

Gene position: 1847951-1848949 (Clockwise)

Preceding gene: 66044885

Following gene: 66044888

Centisome position: 30.33

GC content: 59.06

Gene sequence:

>999_bases
ATGTCTGACGAATGGAAGGCACCCGTTTCGCAAAGCGCGGACGAGGGCATCAATGGCAGGGAAGAGGCTAAAAGCTGGAA
GCTTCTTGAAAAGACGCTGCTGGCCAGTGTTCAGGAACAGCGCCGCGCGCGTCGCTGGGGGATCTTTTTCAAGCTGCTGA
CGTTCGCGTTCCTGTTTGTTGCAGTGATCGTTCCGATGCTGGACTTCGAGGGCGGCACTTCGCGCCGTTCCAGTCACACT
GCGCTGATCGATGTGCAGGGCGTGATTGCCGACAAGGAGGCGGCCAGTGCCGAGAACATCGTCACTGCGCTGCAGAAGGC
CTTCGAGGATGAAAAGACCAAGGGTGTGATTCTGCGTATCAACAGCCCGGGCGGCAGTCCTGTGCAGTCGGGCTATGTCT
ACGACGAAATCCGTCGCCTGCGCGCGGCGAAGCCGGACATCAAGGTGTATGCGGTCATTACCGATCTCGGTGCTTCGGGC
GCTTATTACATCGCCAGCGCCGCTGACCAGATCTATGCCGATAAGGCCAGTCTGGTGGGGTCGATCGGTGTGACGGCAGC
AGGTTTCGGCTTTGTCGGAGCCATGGACAAGCTCGGCGTTGATCGTCGTACCTATACCTCCGGCGAGCACAAGGCGTTCC
TTGACCCGTTCCAGCCACAGAAGGCTGACGAAACGCAGTTCTGGCAGGGTGTGCTGGACACGACTCATCGCCAGTTCATT
GCCAGTGTCAAACAGGGTCGTGGCGACCGCTTGAAGGACAAGGACCACCCAGAGCTGTTCTCCGGGCTGATCTGGACCGG
CGAGCAGGCTGTTGCGCTCGGTCTGGTGGATGGGTTGGGCAGTGCGAGCTATGTCGCGCGGGATGTGATCAAGGAGAAGG
ACATCGTCGAGTACACCGTCGAAGAGTCGCCTTTTGATCGCTTTTCGAAAAAGCTGGGCACCAGCATCGCCGAGCGAATT
GCCATGCTGGTCGGTTTCAACGGCCCAAGCCTGCGTTGA

Upstream 100 bases:

>100_bases
GCGCCAGTTCGAGCCGCGGCTGGCTATCGAGCATTTTTCCGAGCTGCGCACCTGGTTGAACGGGCGCAGCGTCTAGTTTT
CGGGTTGGAGTGATTGGAAC

Downstream 100 bases:

>100_bases
TGGCTTGATGCAGATATAAAGAACCCGGCCACTGGCCGGGTTCTTTGTCTGAGTGTCAGGGTACGCTGACGCCTTCCTTT
ATTAGCATGTCCACCAGACG

Product: peptidase S49, SppA

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSDEWKAPVSQSADEGINGREEAKSWKLLEKTLLASVQEQRRARRWGIFFKLLTFAFLFVAVIVPMLDFEGGTSRRSSHT
ALIDVQGVIADKEAASAENIVTALQKAFEDEKTKGVILRINSPGGSPVQSGYVYDEIRRLRAAKPDIKVYAVITDLGASG
AYYIASAADQIYADKASLVGSIGVTAAGFGFVGAMDKLGVDRRTYTSGEHKAFLDPFQPQKADETQFWQGVLDTTHRQFI
ASVKQGRGDRLKDKDHPELFSGLIWTGEQAVALGLVDGLGSASYVARDVIKEKDIVEYTVEESPFDRFSKKLGTSIAERI
AMLVGFNGPSLR

Sequences:

>Translated_332_residues
MSDEWKAPVSQSADEGINGREEAKSWKLLEKTLLASVQEQRRARRWGIFFKLLTFAFLFVAVIVPMLDFEGGTSRRSSHT
ALIDVQGVIADKEAASAENIVTALQKAFEDEKTKGVILRINSPGGSPVQSGYVYDEIRRLRAAKPDIKVYAVITDLGASG
AYYIASAADQIYADKASLVGSIGVTAAGFGFVGAMDKLGVDRRTYTSGEHKAFLDPFQPQKADETQFWQGVLDTTHRQFI
ASVKQGRGDRLKDKDHPELFSGLIWTGEQAVALGLVDGLGSASYVARDVIKEKDIVEYTVEESPFDRFSKKLGTSIAERI
AMLVGFNGPSLR
>Mature_331_residues
SDEWKAPVSQSADEGINGREEAKSWKLLEKTLLASVQEQRRARRWGIFFKLLTFAFLFVAVIVPMLDFEGGTSRRSSHTA
LIDVQGVIADKEAASAENIVTALQKAFEDEKTKGVILRINSPGGSPVQSGYVYDEIRRLRAAKPDIKVYAVITDLGASGA
YYIASAADQIYADKASLVGSIGVTAAGFGFVGAMDKLGVDRRTYTSGEHKAFLDPFQPQKADETQFWQGVLDTTHRQFIA
SVKQGRGDRLKDKDHPELFSGLIWTGEQAVALGLVDGLGSASYVARDVIKEKDIVEYTVEESPFDRFSKKLGTSIAERIA
MLVGFNGPSLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=230, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788064, Length=222, Percent_Identity=31.5315315315315, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 36365; Mature: 36233

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEWKAPVSQSADEGINGREEAKSWKLLEKTLLASVQEQRRARRWGIFFKLLTFAFLFV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIVPMLDFEGGTSRRSSHTALIDVQGVIADKEAASAENIVTALQKAFEDEKTKGVILRI
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
NSPGGSPVQSGYVYDEIRRLRAAKPDIKVYAVITDLGASGAYYIASAADQIYADKASLVG
ECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHH
SIGVTAAGFGFVGAMDKLGVDRRTYTSGEHKAFLDPFQPQKADETQFWQGVLDTTHRQFI
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASVKQGRGDRLKDKDHPELFSGLIWTGEQAVALGLVDGLGSASYVARDVIKEKDIVEYTV
HHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEEC
EESPFDRFSKKLGTSIAERIAMLVGFNGPSLR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDEWKAPVSQSADEGINGREEAKSWKLLEKTLLASVQEQRRARRWGIFFKLLTFAFLFV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIVPMLDFEGGTSRRSSHTALIDVQGVIADKEAASAENIVTALQKAFEDEKTKGVILRI
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
NSPGGSPVQSGYVYDEIRRLRAAKPDIKVYAVITDLGASGAYYIASAADQIYADKASLVG
ECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHH
SIGVTAAGFGFVGAMDKLGVDRRTYTSGEHKAFLDPFQPQKADETQFWQGVLDTTHRQFI
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASVKQGRGDRLKDKDHPELFSGLIWTGEQAVALGLVDGLGSASYVARDVIKEKDIVEYTV
HHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEEC
EESPFDRFSKKLGTSIAERIAMLVGFNGPSLR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA