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The map label for this gene is copS [H]

Identifier: 66044745

GI number: 66044745

Start: 1686402

End: 1687781

Strand: Direct

Name: copS [H]

Synonym: Psyr_1498

Alternate gene names: 66044745

Gene position: 1686402-1687781 (Clockwise)

Preceding gene: 66044744

Following gene: 66044752

Centisome position: 27.67

GC content: 58.91

Gene sequence:

>1380_bases
ATGAAGCCTGGCTCACTCACCCTGCGCTTAAGCCTTCTGTTTGTGGTCGCGGTCGCCGTCGTCCTTATCATCGTGGGGGT
CGCCTTCAACGAACTGAGCCGTCACCACTTCCGCGCCCTGGATGCGCAGACACTGGGAGAAAAGCTCGAAGCGATTAACC
AGATCGCCATTGAATCAGGCTCGAACCCGGACCTGCTCGAGGCGCGCTGGCACACCCTCCTTGGGGCCCATCCCGACCTC
AGCGCTGTATTTCTGAAGACGGATGGGACGCCTTTTTTTGCAGAACCTCCCCAATCAGCGGCGCCATCGCTCACGCAGGC
CACCCAGCGCGATGGCGTCTGGGAGTGGGAAAACAAAGGCCGCATGTTTAGGGCATTGACTGCCTCGGTATCGTTACCCA
CTGCCAGCCCACCATTGACCGTGTGGCTTGTCCTGGACGTCACCACGCATATGCACTTCTTTGCCATGCTTGAACGCTGG
TTCTGGGGCGTTCTATTGGCTAGTACCGCGTTAAGCGCGGCCCTCGGGTGGCTGGTCGCCAAGAACGGACTGCGGCCGGT
GGCAAGGGTGACCCAGACCGCCGCCTCAATGTCCGCTGGCTCGCTGAAGGAACGCATTCCCTTGGGGCCGGTACCGGATG
AGTTGCGTGAGCTCATCACCGCGTTCAATTCCATGCTTGGTCGCCTGGACGATTCCTTTGTGCGCCTATCGAATTTCTCT
GCTGACATTGCGCACGAGCTTCGTACCCCGATCAGCAACCTGCGGACCCACACCGAGGTGATCCTGGCCAAAAAGCGTGC
GCCCGAGGTGTACGAAGAGAATCTGAGCTCCAATCTGGAAGAGCTCAATCGTCTTTCGGGTATCATCGACGGCATGCTGT
TCCTGGCCAAGTCTGATAACGGGCTAATTGTGCCCGAGGCTGTTGAACTGGATCTGAGAACAGTCATCAGCAAGCTGTTC
GGCTATTACGAGTTTCTGGCCGAGGACAAGGGGATTCAGCTACAAGCATCAGGCAACGCCTCGATCTTCGCTGACAGCGT
GATGATCGACCGTATCGTGTCGAACCTGCTGTCCAATGCCCTGCGCTATACGCCGTCCGGAGAGACGATCAAGGTCAGCA
TCCACGATCACGGAGGAAGGGTAGAGCTTCGGTTGGAAAATCCTGGCCCTGAAATAGCACCGCAGCACCTGGACCGCATC
TTTGACCGGTTCTACCGGGTTGATCCGGCGCGGCGCGAAGGCGCCGGGAATGCGGGGCTGGGGCTGGCGATTGCCCGGTC
CTTGATGCAAGCGCATGGCGGTACTATCTCGTGTACATCCCACGAGGGCCGAACGACCTTCATCCTCACCTTCGTGCGGT
CATCTGGCCCACGAACATGA

Upstream 100 bases:

>100_bases
CCATACGGCGGTTAAGGGCCAAGATTGACGATGACTTCGAGGCAAAACTGCTGCATACCTGCCGGGGAATGGGTTACATG
CTAGACGCGCAGGACGAAGG

Downstream 100 bases:

>100_bases
CATGCCGGCCTGATAGCCTGGGCACCGCTAAGCCAGGCCCCCCAGGCTTGGCGGACATGAAACCGGTTGTCACTGCGCCG
GGTAGTCAGCCACCACCTCC

Product: heavy metal sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKPGSLTLRLSLLFVVAVAVVLIIVGVAFNELSRHHFRALDAQTLGEKLEAINQIAIESGSNPDLLEARWHTLLGAHPDL
SAVFLKTDGTPFFAEPPQSAAPSLTQATQRDGVWEWENKGRMFRALTASVSLPTASPPLTVWLVLDVTTHMHFFAMLERW
FWGVLLASTALSAALGWLVAKNGLRPVARVTQTAASMSAGSLKERIPLGPVPDELRELITAFNSMLGRLDDSFVRLSNFS
ADIAHELRTPISNLRTHTEVILAKKRAPEVYEENLSSNLEELNRLSGIIDGMLFLAKSDNGLIVPEAVELDLRTVISKLF
GYYEFLAEDKGIQLQASGNASIFADSVMIDRIVSNLLSNALRYTPSGETIKVSIHDHGGRVELRLENPGPEIAPQHLDRI
FDRFYRVDPARREGAGNAGLGLAIARSLMQAHGGTISCTSHEGRTTFILTFVRSSGPRT

Sequences:

>Translated_459_residues
MKPGSLTLRLSLLFVVAVAVVLIIVGVAFNELSRHHFRALDAQTLGEKLEAINQIAIESGSNPDLLEARWHTLLGAHPDL
SAVFLKTDGTPFFAEPPQSAAPSLTQATQRDGVWEWENKGRMFRALTASVSLPTASPPLTVWLVLDVTTHMHFFAMLERW
FWGVLLASTALSAALGWLVAKNGLRPVARVTQTAASMSAGSLKERIPLGPVPDELRELITAFNSMLGRLDDSFVRLSNFS
ADIAHELRTPISNLRTHTEVILAKKRAPEVYEENLSSNLEELNRLSGIIDGMLFLAKSDNGLIVPEAVELDLRTVISKLF
GYYEFLAEDKGIQLQASGNASIFADSVMIDRIVSNLLSNALRYTPSGETIKVSIHDHGGRVELRLENPGPEIAPQHLDRI
FDRFYRVDPARREGAGNAGLGLAIARSLMQAHGGTISCTSHEGRTTFILTFVRSSGPRT
>Mature_459_residues
MKPGSLTLRLSLLFVVAVAVVLIIVGVAFNELSRHHFRALDAQTLGEKLEAINQIAIESGSNPDLLEARWHTLLGAHPDL
SAVFLKTDGTPFFAEPPQSAAPSLTQATQRDGVWEWENKGRMFRALTASVSLPTASPPLTVWLVLDVTTHMHFFAMLERW
FWGVLLASTALSAALGWLVAKNGLRPVARVTQTAASMSAGSLKERIPLGPVPDELRELITAFNSMLGRLDDSFVRLSNFS
ADIAHELRTPISNLRTHTEVILAKKRAPEVYEENLSSNLEELNRLSGIIDGMLFLAKSDNGLIVPEAVELDLRTVISKLF
GYYEFLAEDKGIQLQASGNASIFADSVMIDRIVSNLLSNALRYTPSGETIKVSIHDHGGRVELRLENPGPEIAPQHLDRI
FDRFYRVDPARREGAGNAGLGLAIARSLMQAHGGTISCTSHEGRTTFILTFVRSSGPRT

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=321, Percent_Identity=41.4330218068536, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1788279, Length=410, Percent_Identity=28.0487804878049, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=31.25, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=31.25, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=32.1266968325792, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=258, Percent_Identity=26.3565891472868, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789403, Length=235, Percent_Identity=28.0851063829787, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789149, Length=220, Percent_Identity=26.3636363636364, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=29.8245614035088, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=27.2340425531915, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=25.2707581227437, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=26.6932270916335, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=25.4838709677419, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=285, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=348, Percent_Identity=25.5747126436782, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=26.5765765765766, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=219, Percent_Identity=26.9406392694064, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=28.936170212766, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=214, Percent_Identity=26.6355140186916, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50273; Mature: 50273

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPGSLTLRLSLLFVVAVAVVLIIVGVAFNELSRHHFRALDAQTLGEKLEAINQIAIESG
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNPDLLEARWHTLLGAHPDLSAVFLKTDGTPFFAEPPQSAAPSLTQATQRDGVWEWENKG
CCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCEECCCC
RMFRALTASVSLPTASPPLTVWLVLDVTTHMHFFAMLERWFWGVLLASTALSAALGWLVA
CEEEEHHHEEECCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNGLRPVARVTQTAASMSAGSLKERIPLGPVPDELRELITAFNSMLGRLDDSFVRLSNFS
HCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCC
ADIAHELRTPISNLRTHTEVILAKKRAPEVYEENLSSNLEELNRLSGIIDGMLFLAKSDN
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
GLIVPEAVELDLRTVISKLFGYYEFLAEDKGIQLQASGNASIFADSVMIDRIVSNLLSNA
CEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHH
LRYTPSGETIKVSIHDHGGRVELRLENPGPEIAPQHLDRIFDRFYRVDPARREGAGNAGL
HEECCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCH
GLAIARSLMQAHGGTISCTSHEGRTTFILTFVRSSGPRT
HHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEECCCCCC
>Mature Secondary Structure
MKPGSLTLRLSLLFVVAVAVVLIIVGVAFNELSRHHFRALDAQTLGEKLEAINQIAIESG
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNPDLLEARWHTLLGAHPDLSAVFLKTDGTPFFAEPPQSAAPSLTQATQRDGVWEWENKG
CCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCEECCCC
RMFRALTASVSLPTASPPLTVWLVLDVTTHMHFFAMLERWFWGVLLASTALSAALGWLVA
CEEEEHHHEEECCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNGLRPVARVTQTAASMSAGSLKERIPLGPVPDELRELITAFNSMLGRLDDSFVRLSNFS
HCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCC
ADIAHELRTPISNLRTHTEVILAKKRAPEVYEENLSSNLEELNRLSGIIDGMLFLAKSDN
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
GLIVPEAVELDLRTVISKLFGYYEFLAEDKGIQLQASGNASIFADSVMIDRIVSNLLSNA
CEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHH
LRYTPSGETIKVSIHDHGGRVELRLENPGPEIAPQHLDRIFDRFYRVDPARREGAGNAGL
HEECCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCH
GLAIARSLMQAHGGTISCTSHEGRTTFILTFVRSSGPRT
HHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]