Click here to switch to the map view.

The map label for this gene is copR [H]

Identifier: 66044744

GI number: 66044744

Start: 1685719

End: 1686405

Strand: Direct

Name: copR [H]

Synonym: Psyr_1497

Alternate gene names: 66044744

Gene position: 1685719-1686405 (Clockwise)

Preceding gene: 66044743

Following gene: 66044745

Centisome position: 27.66

GC content: 56.04

Gene sequence:

>687_bases
ATGAAACTGCTGGTAGCCGAAGACGAACCTAAAACTGGAATCTATCTGCAGCAAGGCCTGCGGGAGGCTGGCTTCAATGT
GGACCGCGTGGTCACAGGCACAGATGCCGTTGACCAGGCGCTCAATGAAGCCTATGACCTGTTGATTCTCGACGTGATGA
TGCCAGGCCTCGATGGCTGGGAAGTCATCAGACGCCTTCGCACCGTTGGCCAATCCGTACCGGTACTGTTTCTGACCGCA
CGCGACGGGGTAGACGACCGAGTCAAGGGGCTGGAGCTGGGCGCCGATGATTACCTGGTTAAGCCATTTGCTTTTTCAGA
ATTGCTGGCACGGGTGCGAACGCTACTGCGGCGCGGCAGCAGCAACCTCCCGGTTCAAACTAGCTTGCAAATCGGAGACC
TTCAGGTGGATTTGCTCAAGCGTCGAGCCACCCGGGGCGGCAAGCGAATCGACCTCACGGCCAAAGAGTTTGCACTGCTG
GAATTGCTGATGCGCCGGCAAGGTGAGGTGCTGTCCAAATCGCTGATAGCTTCCCAAGTCTGGGACATGAATTTTGACAG
CGACACAAATGTCATTGAAGTGGCCATACGGCGGTTAAGGGCCAAGATTGACGATGACTTCGAGGCAAAACTGCTGCATA
CCTGCCGGGGAATGGGTTACATGCTAGACGCGCAGGACGAAGGATGA

Upstream 100 bases:

>100_bases
GCCTGGCTTGGCACGCTGTCCCCTGAGATGGAAGCGGGGATGTGAGTGTGCCTAGCCCTGTTTTACCGTCACACTGGGCC
GGTGCCGTGGAGGGTCAAAC

Downstream 100 bases:

>100_bases
AGCCTGGCTCACTCACCCTGCGCTTAAGCCTTCTGTTTGTGGTCGCGGTCGCCGTCGTCCTTATCATCGTGGGGGTCGCC
TTCAACGAACTGAGCCGTCA

Product: heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVAEDEPKTGIYLQQGLREAGFNVDRVVTGTDAVDQALNEAYDLLILDVMMPGLDGWEVIRRLRTVGQSVPVLFLTA
RDGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGSSNLPVQTSLQIGDLQVDLLKRRATRGGKRIDLTAKEFALL
ELLMRRQGEVLSKSLIASQVWDMNFDSDTNVIEVAIRRLRAKIDDDFEAKLLHTCRGMGYMLDAQDEG

Sequences:

>Translated_228_residues
MKLLVAEDEPKTGIYLQQGLREAGFNVDRVVTGTDAVDQALNEAYDLLILDVMMPGLDGWEVIRRLRTVGQSVPVLFLTA
RDGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGSSNLPVQTSLQIGDLQVDLLKRRATRGGKRIDLTAKEFALL
ELLMRRQGEVLSKSLIASQVWDMNFDSDTNVIEVAIRRLRAKIDDDFEAKLLHTCRGMGYMLDAQDEG
>Mature_228_residues
MKLLVAEDEPKTGIYLQQGLREAGFNVDRVVTGTDAVDQALNEAYDLLILDVMMPGLDGWEVIRRLRTVGQSVPVLFLTA
RDGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGSSNLPVQTSLQIGDLQVDLLKRRATRGGKRIDLTAKEFALL
ELLMRRQGEVLSKSLIASQVWDMNFDSDTNVIEVAIRRLRAKIDDDFEAKLLHTCRGMGYMLDAQDEG

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=60.6194690265487, Blast_Score=284, Evalue=3e-78,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=52.7272727272727, Blast_Score=231, Evalue=2e-62,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=42.3423423423423, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=39.0557939914163, Blast_Score=146, Evalue=9e-37,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.0877192982456, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=36.6071428571429, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=34.6846846846847, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=36.6515837104072, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.4821428571429, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.1990950226244, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.0877192982456, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.4410480349345, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=29.5652173913043, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790437, Length=133, Percent_Identity=33.0827067669173, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=35.6521739130435, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788550, Length=137, Percent_Identity=27.007299270073, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25550; Mature: 25550

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVAEDEPKTGIYLQQGLREAGFNVDRVVTGTDAVDQALNEAYDLLILDVMMPGLDGW
CEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHH
EVIRRLRTVGQSVPVLFLTARDGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGS
HHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
SNLPVQTSLQIGDLQVDLLKRRATRGGKRIDLTAKEFALLELLMRRQGEVLSKSLIASQV
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WDMNFDSDTNVIEVAIRRLRAKIDDDFEAKLLHTCRGMGYMLDAQDEG
HCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure
MKLLVAEDEPKTGIYLQQGLREAGFNVDRVVTGTDAVDQALNEAYDLLILDVMMPGLDGW
CEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHH
EVIRRLRTVGQSVPVLFLTARDGVDDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGS
HHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
SNLPVQTSLQIGDLQVDLLKRRATRGGKRIDLTAKEFALLELLMRRQGEVLSKSLIASQV
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WDMNFDSDTNVIEVAIRRLRAKIDDDFEAKLLHTCRGMGYMLDAQDEG
HCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]