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The map label for this gene is copA [H]

Identifier: 66044740

GI number: 66044740

Start: 1681519

End: 1683339

Strand: Direct

Name: copA [H]

Synonym: Psyr_1493

Alternate gene names: 66044740

Gene position: 1681519-1683339 (Clockwise)

Preceding gene: 66044739

Following gene: 66044741

Centisome position: 27.59

GC content: 58.87

Gene sequence:

>1821_bases
ATGGAATCAAGAACTTCTCGACGTACTTTCGTCAAAGGCCTCGCGGCTGCCGGCGTGCTAGGTGGGCTAGGCTTGTGGCG
TTCGCCCAGTTGGGCGGCGTCCGGCTCGGCGGCGCTCAGCGTGTTGAGCGGTACGGAGTACGACCTGTCTATTGGCGAGA
TGCTGGTAAACATCACCGGCAAACGTCGCACAGCGATGGCGATCAACGGCGGGCTGCCTGGTCCCTTGCTGCGCTGGAAA
GAGGGTGACACGGTCACGCTCCGGGTACGCAACCGACTCGACGCTGCAACCTCCATACACTGGCACGGCATCATCCTGCC
GCCAAACATGGACGGTGTACCAGGGCTGAGCTTTGCGGGCATCGAGCCGGGTGGCGTGTACGTCTACCAGTTCAAGCTCC
AACAGAACGGGACGTATTGGTACCACAGCCACTCCGGGTTCCAGGAACAGGTAGGGGTGTATGGCCCTCTGGTTATCGAG
GCGAAAGAGCCCGAGCCTTTCAAGTACGACAGTGAACATGTGGTGATGCTGACGGACTGGACGGATGAAGATCCAGTCGC
GCTGATGCGTACCCTCAAAAAGCAGTCCGATTACTACAACTTCCACAAGCGCACAGTCGGTGACTTCGTCAACGATGTGG
CTGATAAGGGCTGGGCCGCAACCGTCGCGGATCGCAAGATGTGGGCCGAGATGAAGATGAACCCCACAGACCTTGCGGAC
GTGAGCGGGGCCACCTACACGTACCTGCTCAATGGTCAGGCCCCCAATATGAACTGGACCGGCTTGTTCCGTCCTGGCGA
AAAGGTGCGCCTTCGGTTCATCAACGGCTCGGCTATGACGTACTTCGACATCCGTATTCCAGGCCTGAAAATGACCGTGG
TAGCGTCGGATGGCCAGTACGTGAACCCGGTTAAGGTCGATGAATTACGCATCGCCGTGGCCGAAACCTTCGATGTGATC
GTTGAGCCCACTGCCGAAGCGTACACGGTCTTTGCTCAATCCATGGATCGCACGGGCTACGCTCGCGGCACCCTGGCCGT
GCGGGAAGGCTTGGTAGCCCAGGTTCCCCCTCTTGATGCTCGTCCGCTGGTTACGATGGACGATATGGGAATGGGTGGTA
TGGACCATGGCAGCATGGGCAGCATGGATTCGGGTGCTGACGACGGCATGCAGACCATGAGCAGCATGGGAGGCAATTCT
ATGCCCGCCATGGACCACAGCAAAATGTCGACCATGCAGGGTATGGACCACGGCGCTATGCCGGGCATGGACCATGATTC
GATGGGCGGCATGGTAATGCAGAGCCACCCTGCCAGCGAGAAAAACAACCCGCTAGTGGACATGCAGGCCATGAGCCCCA
CCGCCAAGCTGAACGATCCTGGCCTAGGCCTGCGTAATAACGGGCGCAAGGTGCTCACCTATGCCGACCTTAAAAGCACC
TTCGAAGACCCAGACGGGCGTGAGCCGAGCCGGACCATTGAGCTGCACCTGACGGGGCACATGGAAAAATTTGCCTGGTC
GTTTGATGGCATCAAATTCGCGGACGCTCAACCTCTGGTACTCAAATACGGCGAGCGGGTGAGAATCGTGCTGGTGAACG
ACACGATGATGACTCACCCAATCCATCTGCATGGGATGTGGAGTGACCTGGAGGACGAGGACGGAAACTTCAGGGTGCGC
AAGCACACCATCGATATGCCGCCAGGCTCCAAGCGCAGCTACCGTGTCACCGCCGATGCCCTGGGGCGCTGGGCCTATCA
CTGTCACCTGCTCTACCACATGGAGATGGGTATGTTCCGCGAAGTTCGGGTAGAGGAGTGA

Upstream 100 bases:

>100_bases
TGTAATCGCGCCGCTTACGATGCTGTGACATCGTCCACTACAGTTCCTTAAACCCAGCACACGGCTTAGTTGCCGTCCTT
GCCTACCTGGACCCGCGCGT

Downstream 100 bases:

>100_bases
AGCCAATGACTGTTTTGAATCGACTCCACGTTTGCTCACTGCTCGCGGTCACCGGCCTGGGAATGCTCCCAGGGGGCGCG
TTTGCGGCAGAGGCCGTGAT

Product: twin-arginine translocation pathway signal:copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MESRTSRRTFVKGLAAAGVLGGLGLWRSPSWAASGSAALSVLSGTEYDLSIGEMLVNITGKRRTAMAINGGLPGPLLRWK
EGDTVTLRVRNRLDAATSIHWHGIILPPNMDGVPGLSFAGIEPGGVYVYQFKLQQNGTYWYHSHSGFQEQVGVYGPLVIE
AKEPEPFKYDSEHVVMLTDWTDEDPVALMRTLKKQSDYYNFHKRTVGDFVNDVADKGWAATVADRKMWAEMKMNPTDLAD
VSGATYTYLLNGQAPNMNWTGLFRPGEKVRLRFINGSAMTYFDIRIPGLKMTVVASDGQYVNPVKVDELRIAVAETFDVI
VEPTAEAYTVFAQSMDRTGYARGTLAVREGLVAQVPPLDARPLVTMDDMGMGGMDHGSMGSMDSGADDGMQTMSSMGGNS
MPAMDHSKMSTMQGMDHGAMPGMDHDSMGGMVMQSHPASEKNNPLVDMQAMSPTAKLNDPGLGLRNNGRKVLTYADLKST
FEDPDGREPSRTIELHLTGHMEKFAWSFDGIKFADAQPLVLKYGERVRIVLVNDTMMTHPIHLHGMWSDLEDEDGNFRVR
KHTIDMPPGSKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE

Sequences:

>Translated_606_residues
MESRTSRRTFVKGLAAAGVLGGLGLWRSPSWAASGSAALSVLSGTEYDLSIGEMLVNITGKRRTAMAINGGLPGPLLRWK
EGDTVTLRVRNRLDAATSIHWHGIILPPNMDGVPGLSFAGIEPGGVYVYQFKLQQNGTYWYHSHSGFQEQVGVYGPLVIE
AKEPEPFKYDSEHVVMLTDWTDEDPVALMRTLKKQSDYYNFHKRTVGDFVNDVADKGWAATVADRKMWAEMKMNPTDLAD
VSGATYTYLLNGQAPNMNWTGLFRPGEKVRLRFINGSAMTYFDIRIPGLKMTVVASDGQYVNPVKVDELRIAVAETFDVI
VEPTAEAYTVFAQSMDRTGYARGTLAVREGLVAQVPPLDARPLVTMDDMGMGGMDHGSMGSMDSGADDGMQTMSSMGGNS
MPAMDHSKMSTMQGMDHGAMPGMDHDSMGGMVMQSHPASEKNNPLVDMQAMSPTAKLNDPGLGLRNNGRKVLTYADLKST
FEDPDGREPSRTIELHLTGHMEKFAWSFDGIKFADAQPLVLKYGERVRIVLVNDTMMTHPIHLHGMWSDLEDEDGNFRVR
KHTIDMPPGSKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE
>Mature_606_residues
MESRTSRRTFVKGLAAAGVLGGLGLWRSPSWAASGSAALSVLSGTEYDLSIGEMLVNITGKRRTAMAINGGLPGPLLRWK
EGDTVTLRVRNRLDAATSIHWHGIILPPNMDGVPGLSFAGIEPGGVYVYQFKLQQNGTYWYHSHSGFQEQVGVYGPLVIE
AKEPEPFKYDSEHVVMLTDWTDEDPVALMRTLKKQSDYYNFHKRTVGDFVNDVADKGWAATVADRKMWAEMKMNPTDLAD
VSGATYTYLLNGQAPNMNWTGLFRPGEKVRLRFINGSAMTYFDIRIPGLKMTVVASDGQYVNPVKVDELRIAVAETFDVI
VEPTAEAYTVFAQSMDRTGYARGTLAVREGLVAQVPPLDARPLVTMDDMGMGGMDHGSMGSMDSGADDGMQTMSSMGGNS
MPAMDHSKMSTMQGMDHGAMPGMDHDSMGGMVMQSHPASEKNNPLVDMQAMSPTAKLNDPGLGLRNNGRKVLTYADLKST
FEDPDGREPSRTIELHLTGHMEKFAWSFDGIKFADAQPLVLKYGERVRIVLVNDTMMTHPIHLHGMWSDLEDEDGNFRVR
KHTIDMPPGSKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=621, Percent_Identity=25.1207729468599, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17539950, Length=328, Percent_Identity=24.0853658536585, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=270, Percent_Identity=27.4074074074074, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320714, Length=288, Percent_Identity=25.6944444444444, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=291, Percent_Identity=28.5223367697594, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574104, Length=628, Percent_Identity=23.7261146496815, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24650186, Length=597, Percent_Identity=21.608040201005, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859919, Length=303, Percent_Identity=28.7128712871287, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360167, Length=284, Percent_Identity=26.056338028169, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24585842, Length=284, Percent_Identity=26.056338028169, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330000, Length=283, Percent_Identity=26.1484098939929, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221329998, Length=284, Percent_Identity=26.056338028169, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67085; Mature: 67085

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRTSRRTFVKGLAAAGVLGGLGLWRSPSWAASGSAALSVLSGTEYDLSIGEMLVNITG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHEEEEECC
KRRTAMAINGGLPGPLLRWKEGDTVTLRVRNRLDAATSIHWHGIILPPNMDGVPGLSFAG
CCEEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCEECC
IEPGGVYVYQFKLQQNGTYWYHSHSGFQEQVGVYGPLVIEAKEPEPFKYDSEHVVMLTDW
CCCCCEEEEEEEEECCCEEEEECCCCHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECC
TDEDPVALMRTLKKQSDYYNFHKRTVGDFVNDVADKGWAATVADRKMWAEMKMNPTDLAD
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCHHH
VSGATYTYLLNGQAPNMNWTGLFRPGEKVRLRFINGSAMTYFDIRIPGLKMTVVASDGQY
CCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCEEEEEEEEECCEEEEEEECCCCE
VNPVKVDELRIAVAETFDVIVEPTAEAYTVFAQSMDRTGYARGTLAVREGLVAQVPPLDA
ECCEEECCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCC
RPLVTMDDMGMGGMDHGSMGSMDSGADDGMQTMSSMGGNSMPAMDHSKMSTMQGMDHGAM
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCC
PGMDHDSMGGMVMQSHPASEKNNPLVDMQAMSPTAKLNDPGLGLRNNGRKVLTYADLKST
CCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECHHHH
FEDPDGREPSRTIELHLTGHMEKFAWSFDGIKFADAQPLVLKYGERVRIVLVNDTMMTHP
CCCCCCCCCCEEEEEEEECCCHHHEEECCCEEECCCCCCEEECCCEEEEEEEECCEEECC
IHLHGMWSDLEDEDGNFRVRKHTIDMPPGSKRSYRVTADALGRWAYHCHLLYHMEMGMFR
EEEEECCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHCCEEEEEEEEEECCCCEE
EVRVEE
EEEECC
>Mature Secondary Structure
MESRTSRRTFVKGLAAAGVLGGLGLWRSPSWAASGSAALSVLSGTEYDLSIGEMLVNITG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHEEEEECC
KRRTAMAINGGLPGPLLRWKEGDTVTLRVRNRLDAATSIHWHGIILPPNMDGVPGLSFAG
CCEEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCEECC
IEPGGVYVYQFKLQQNGTYWYHSHSGFQEQVGVYGPLVIEAKEPEPFKYDSEHVVMLTDW
CCCCCEEEEEEEEECCCEEEEECCCCHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECC
TDEDPVALMRTLKKQSDYYNFHKRTVGDFVNDVADKGWAATVADRKMWAEMKMNPTDLAD
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCHHH
VSGATYTYLLNGQAPNMNWTGLFRPGEKVRLRFINGSAMTYFDIRIPGLKMTVVASDGQY
CCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCEEEEEEEEECCEEEEEEECCCCE
VNPVKVDELRIAVAETFDVIVEPTAEAYTVFAQSMDRTGYARGTLAVREGLVAQVPPLDA
ECCEEECCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCC
RPLVTMDDMGMGGMDHGSMGSMDSGADDGMQTMSSMGGNSMPAMDHSKMSTMQGMDHGAM
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCC
PGMDHDSMGGMVMQSHPASEKNNPLVDMQAMSPTAKLNDPGLGLRNNGRKVLTYADLKST
CCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECHHHH
FEDPDGREPSRTIELHLTGHMEKFAWSFDGIKFADAQPLVLKYGERVRIVLVNDTMMTHP
CCCCCCCCCCEEEEEEEECCCHHHEEECCCEEECCCCCCEEECCCEEEEEEEECCEEECC
IHLHGMWSDLEDEDGNFRVRKHTIDMPPGSKRSYRVTADALGRWAYHCHLLYHMEMGMFR
EEEEECCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHCCEEEEEEEEEECCCCEE
EVRVEE
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]