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The map label for this gene is umuC [H]

Identifier: 66044673

GI number: 66044673

Start: 1612927

End: 1614207

Strand: Direct

Name: umuC [H]

Synonym: Psyr_1425

Alternate gene names: 66044673

Gene position: 1612927-1614207 (Clockwise)

Preceding gene: 66044672

Following gene: 66044679

Centisome position: 26.47

GC content: 55.66

Gene sequence:

>1281_bases
ATGGAAAAGCGTGAGGCTGTCTTCGCGCTAATCGACTGCAATTGCTTCTATGCCAGCTGCGAGCGTGTTTTTCGTCCAGA
TCTGGAGAAAACGCCCATCGTGGTACTCAGCAATAACGACGGTTGCGTCATCGCCCGTAGCTACGACGCCAAGCCATTTG
TGAAAATGGGCGCTCCCTATTTTCAGATCAGAGAGGTGTTGCGCCGCAACGGCATCAAGGTGTTCAGCAGCAACTATGCA
CTCTATGGCGACATGAGCGAGCGTGTCATGTCGATCATCGAGTCGATGGTGCCAGCCTCCGAGGTCTACAGCATCGATGA
GGCGTTCGCAGACCTCACCGGCGTGCCTGGCGATCTCACAGCGTTCGGTCGACGCATCCGGGCGAACATTCTTAAATGCA
CTGGCATTCCTGTGGGTGTGGGTATCGGTCCTACGAAAACGCTCGCCAAGCTGGCAAACCACACTGCTAAGCGACTGCTA
TCCCATACAGGCGGTGTTGTAGACATTTGCGACCTGCATAACCGCAACTGGGTACTGCGTAATACGGCGGTCTCAGAGGT
CTGGGGGGTAGGGAAGAAGATGAATGCCCACCTGGAGGCTATGAACATCCGCACCGCAATGGACCTTGCAACCGCCGACC
CGCGTACTCTGCGCGAACGGTTCAGCGTGGTCATTGAAAAGACCGCACGTGAGCTGGCAGGTACTTCGTGCCTGGAGCTG
GGCGAAGCTGCACCACCCAAGCAGGAGATCTGTTGCAGCCGAATGTTCGGCAAACGGCTAACCACCATTCAGCCTATCAA
AGAGGCGGTGGCCACCTACACTCAGCGTGCGGCCGAGAAGCTCCGTTCTCAAAACTCGCTGTGCAAGAAGATCCGCGTCA
GCATCCGTACCGGCATGTTCAATCCGGAAGAAGCCAAGTACGCCAACGGCGCTTTGGTTGAATTGCCATACCCCACCAAC
GACGTGCGCTTGATGACCAGGGCGGCGACTGAGGCAGTGAATCGTTTGTTTCGACCGGGGTTCAAGTACAGCAAAGCTGA
GGTTCTGTTGCTGGATCTGAGACAGCCTGGCGAATTTACGGATGACATGTTCGCTGCTTCGCAGCCGGCATCTTCAGAGA
AGGTGATGGGAGTCCTGGATGAGATCAATACACGCTGGGGCAGAGGGACTTTACGAGCTGGGAGTGTTCCTTCCAATCCG
GAGTGGGCTATGCGTCGCGAGCTGATGAGTCAAAGTTATACGACCAGGCTCGATCAGTTGTGGGAGGTGAAAAGTGTGTA
A

Upstream 100 bases:

>100_bases
GTCAAACTTCAATCCGAAAATAGTGCCTACCCGTCCAAGCACATCCTGGAGGGTGACAACCTCGTCATCTGGGGCGTAGT
GAACTACAGCATGCGCCGTC

Downstream 100 bases:

>100_bases
GGGCTCTGTAAGGTTAAGGATCAAGGCGTGAATAGACTAGGATTACTGGAACAGTCTTTCATTCGGAAACACTGTCGAAC
CGAAGGCCGATACGGTATGA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MEKREAVFALIDCNCFYASCERVFRPDLEKTPIVVLSNNDGCVIARSYDAKPFVKMGAPYFQIREVLRRNGIKVFSSNYA
LYGDMSERVMSIIESMVPASEVYSIDEAFADLTGVPGDLTAFGRRIRANILKCTGIPVGVGIGPTKTLAKLANHTAKRLL
SHTGGVVDICDLHNRNWVLRNTAVSEVWGVGKKMNAHLEAMNIRTAMDLATADPRTLRERFSVVIEKTARELAGTSCLEL
GEAAPPKQEICCSRMFGKRLTTIQPIKEAVATYTQRAAEKLRSQNSLCKKIRVSIRTGMFNPEEAKYANGALVELPYPTN
DVRLMTRAATEAVNRLFRPGFKYSKAEVLLLDLRQPGEFTDDMFAASQPASSEKVMGVLDEINTRWGRGTLRAGSVPSNP
EWAMRRELMSQSYTTRLDQLWEVKSV

Sequences:

>Translated_426_residues
MEKREAVFALIDCNCFYASCERVFRPDLEKTPIVVLSNNDGCVIARSYDAKPFVKMGAPYFQIREVLRRNGIKVFSSNYA
LYGDMSERVMSIIESMVPASEVYSIDEAFADLTGVPGDLTAFGRRIRANILKCTGIPVGVGIGPTKTLAKLANHTAKRLL
SHTGGVVDICDLHNRNWVLRNTAVSEVWGVGKKMNAHLEAMNIRTAMDLATADPRTLRERFSVVIEKTARELAGTSCLEL
GEAAPPKQEICCSRMFGKRLTTIQPIKEAVATYTQRAAEKLRSQNSLCKKIRVSIRTGMFNPEEAKYANGALVELPYPTN
DVRLMTRAATEAVNRLFRPGFKYSKAEVLLLDLRQPGEFTDDMFAASQPASSEKVMGVLDEINTRWGRGTLRAGSVPSNP
EWAMRRELMSQSYTTRLDQLWEVKSV
>Mature_426_residues
MEKREAVFALIDCNCFYASCERVFRPDLEKTPIVVLSNNDGCVIARSYDAKPFVKMGAPYFQIREVLRRNGIKVFSSNYA
LYGDMSERVMSIIESMVPASEVYSIDEAFADLTGVPGDLTAFGRRIRANILKCTGIPVGVGIGPTKTLAKLANHTAKRLL
SHTGGVVDICDLHNRNWVLRNTAVSEVWGVGKKMNAHLEAMNIRTAMDLATADPRTLRERFSVVIEKTARELAGTSCLEL
GEAAPPKQEICCSRMFGKRLTTIQPIKEAVATYTQRAAEKLRSQNSLCKKIRVSIRTGMFNPEEAKYANGALVELPYPTN
DVRLMTRAATEAVNRLFRPGFKYSKAEVLLLDLRQPGEFTDDMFAASQPASSEKVMGVLDEINTRWGRGTLRAGSVPSNP
EWAMRRELMSQSYTTRLDQLWEVKSV

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=49.2890995260664, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47479; Mature: 47479

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKREAVFALIDCNCFYASCERVFRPDLEKTPIVVLSNNDGCVIARSYDAKPFVKMGAPY
CCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHCCCH
FQIREVLRRNGIKVFSSNYALYGDMSERVMSIIESMVPASEVYSIDEAFADLTGVPGDLT
HHHHHHHHHCCCEEEECCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHH
AFGRRIRANILKCTGIPVGVGIGPTKTLAKLANHTAKRLLSHTGGVVDICDLHNRNWVLR
HHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEE
NTAVSEVWGVGKKMNAHLEAMNIRTAMDLATADPRTLRERFSVVIEKTARELAGTSCLEL
CCHHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
GEAAPPKQEICCSRMFGKRLTTIQPIKEAVATYTQRAAEKLRSQNSLCKKIRVSIRTGMF
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPEEAKYANGALVELPYPTNDVRLMTRAATEAVNRLFRPGFKYSKAEVLLLDLRQPGEFT
CCCHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
DDMFAASQPASSEKVMGVLDEINTRWGRGTLRAGSVPSNPEWAMRRELMSQSYTTRLDQL
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
WEVKSV
HHHCCC
>Mature Secondary Structure
MEKREAVFALIDCNCFYASCERVFRPDLEKTPIVVLSNNDGCVIARSYDAKPFVKMGAPY
CCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHCCCH
FQIREVLRRNGIKVFSSNYALYGDMSERVMSIIESMVPASEVYSIDEAFADLTGVPGDLT
HHHHHHHHHCCCEEEECCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHH
AFGRRIRANILKCTGIPVGVGIGPTKTLAKLANHTAKRLLSHTGGVVDICDLHNRNWVLR
HHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEE
NTAVSEVWGVGKKMNAHLEAMNIRTAMDLATADPRTLRERFSVVIEKTARELAGTSCLEL
CCHHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
GEAAPPKQEICCSRMFGKRLTTIQPIKEAVATYTQRAAEKLRSQNSLCKKIRVSIRTGMF
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPEEAKYANGALVELPYPTNDVRLMTRAATEAVNRLFRPGFKYSKAEVLLLDLRQPGEFT
CCCHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
DDMFAASQPASSEKVMGVLDEINTRWGRGTLRAGSVPSNPEWAMRRELMSQSYTTRLDQL
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
WEVKSV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]