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The map label for this gene is frmA [H]

Identifier: 66044615

GI number: 66044615

Start: 1550472

End: 1551584

Strand: Direct

Name: frmA [H]

Synonym: Psyr_1367

Alternate gene names: 66044615

Gene position: 1550472-1551584 (Clockwise)

Preceding gene: 66044613

Following gene: 66044616

Centisome position: 25.44

GC content: 59.3

Gene sequence:

>1113_bases
ATGATCAAGTCGCGCGCTGCTGTCGCTTTTGAAGCCAAAAAGCCATTGGAGATCGTTGAAGTCGATGTGGCCATGCCCAA
GGCGGGAGAAGTGCTGCTCAGAGTAGTAGCCTCCGGCGTTTGCCACACCGATGCCTACACATTGTCCGGGGCTGACCCTG
AAGGGATTTTTCCGTCGATCCTCGGCCACGAAGGTGGTGCGATTGTCGAAGCGGTGGGTGAGGGCGTGACCTCGGTGGTG
GTCGGCGACCACGTGATTCCGCTGTACACCCCGGAATGCCGTCAGTGCAAGTTCTGCCGCTCGGGCAAGACCAACCTGTG
CCAGGCGATTCGTGCCACGCAGGGTAAAGGCCTGATGCCGGATGGCACCACGCGCTTTTCCTACAAGGGCGAGCCGATTT
TCCATTACATGGGCACCTCGACCTTCTCCGAATACACCGTACTGCCGGAAATCTCGGTGGCCAAAATCGACAAGCAGGCA
CCGCTGGAAAAAGTCTGCCTGCTGGGATGTGGCGTCACCACCGGTATCGGTGCGGTGCTCAACACCGCCAAGGTCAAGCC
TGGTGATACCGTGGCCATCTTCGGTCTGGGCGGTATTGGCCTCTCGGCATTGATCGGTGCGGTCAAAGCCAAGGCGGCTC
GAATCATCGCCATCGACATCAACCCGGCCAAGTTCGAGATCGCCAAACAGCTGGGCGCGACTGATTGCGTCAATCCGAAG
GATTTCGACCGTCCGATCCAGGAAGTCATCGTCGACATGACCGATGGCGGCGTCGACTTCTCGTTTGAGTGCATCGGTAA
TGTGCAACTGATGCGTGCAGCGCTGGAATCCTGCCACAAGGGCTGGGGCGAGTCGGTCATCATCGGCGTGGCCGGCGCCG
GTCAGGAAATCGCTACCCGTCCGTTCCAGCTGGTGACCGGGCGCGTCTGGCGCGGTTCGGCATTTGGCGGCGTGCGTGGC
CGTACCGAATTGCCGAGCTATGTGGACATGGCGCAGACCGGAGAAATCCCGCTGGATACGTTCATCACCCACACCATGGG
CCTGGAGGGAATCAACAAGGCGTTCGACCTGATGCATGAAGGCAAAAGCATCCGCACCGTCATTCATTTTTAA

Upstream 100 bases:

>100_bases
TATCCCTGTACAGCATTAATGTTTTGCTTTTAGCCGCATTACTCGTCAATTGGCACTGTACTACACTGCAATCCTTGTTT
TTACCCGTCGGAGAAGATTG

Downstream 100 bases:

>100_bases
GGAGCAGCGGCAAGCTGTCAGCTCCAAGCGGCAAGCACGAAGGTCTCTTACCTGCTTGTAGCTTGCGGCTTATAGCTTGC
AGCTGGAGGACATCACATGC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSILGHEGGAIVEAVGEGVTSVV
VGDHVIPLYTPECRQCKFCRSGKTNLCQAIRATQGKGLMPDGTTRFSYKGEPIFHYMGTSTFSEYTVLPEISVAKIDKQA
PLEKVCLLGCGVTTGIGAVLNTAKVKPGDTVAIFGLGGIGLSALIGAVKAKAARIIAIDINPAKFEIAKQLGATDCVNPK
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALESCHKGWGESVIIGVAGAGQEIATRPFQLVTGRVWRGSAFGGVRG
RTELPSYVDMAQTGEIPLDTFITHTMGLEGINKAFDLMHEGKSIRTVIHF

Sequences:

>Translated_370_residues
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSILGHEGGAIVEAVGEGVTSVV
VGDHVIPLYTPECRQCKFCRSGKTNLCQAIRATQGKGLMPDGTTRFSYKGEPIFHYMGTSTFSEYTVLPEISVAKIDKQA
PLEKVCLLGCGVTTGIGAVLNTAKVKPGDTVAIFGLGGIGLSALIGAVKAKAARIIAIDINPAKFEIAKQLGATDCVNPK
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALESCHKGWGESVIIGVAGAGQEIATRPFQLVTGRVWRGSAFGGVRG
RTELPSYVDMAQTGEIPLDTFITHTMGLEGINKAFDLMHEGKSIRTVIHF
>Mature_370_residues
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSILGHEGGAIVEAVGEGVTSVV
VGDHVIPLYTPECRQCKFCRSGKTNLCQAIRATQGKGLMPDGTTRFSYKGEPIFHYMGTSTFSEYTVLPEISVAKIDKQA
PLEKVCLLGCGVTTGIGAVLNTAKVKPGDTVAIFGLGGIGLSALIGAVKAKAARIIAIDINPAKFEIAKQLGATDCVNPK
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALESCHKGWGESVIIGVAGAGQEIATRPFQLVTGRVWRGSAFGGVRG
RTELPSYVDMAQTGEIPLDTFITHTMGLEGINKAFDLMHEGKSIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=65.2173913043478, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=52.972972972973, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=51.6216216216216, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=51.3513513513513, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=51.4666666666667, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=48.7870619946092, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=48.7870619946092, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=48.3695652173913, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=48.6187845303867, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=70.7317073170732, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=25.2631578947368, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787863, Length=366, Percent_Identity=25.6830601092896, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=366, Percent_Identity=25.6830601092896, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788073, Length=348, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081918, Length=227, Percent_Identity=33.0396475770925, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786825, Length=256, Percent_Identity=26.953125, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI226510992, Length=235, Percent_Identity=25.9574468085106, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=244, Percent_Identity=27.4590163934426, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788075, Length=372, Percent_Identity=25.2688172043011, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=56.6844919786096, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=56.3829787234042, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=56.268221574344, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562584, Length=375, Percent_Identity=28.5333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=375, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=359, Percent_Identity=23.3983286908078, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=375, Percent_Identity=26.9333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=359, Percent_Identity=22.2841225626741, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.377358490566, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319621, Length=278, Percent_Identity=31.294964028777, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=365, Percent_Identity=27.9452054794521, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=27.9141104294479, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=390, Percent_Identity=27.6923076923077, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=26.9113149847095, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737895, Length=372, Percent_Identity=62.6344086021505, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=26.4367816091954, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737897, Length=357, Percent_Identity=24.0896358543417, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39198; Mature: 39198

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSI
CCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHH
LGHEGGAIVEAVGEGVTSVVVGDHVIPLYTPECRQCKFCRSGKTNLCQAIRATQGKGLMP
HCCCCCHHHHHHHCCCEEEEECCEEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DGTTRFSYKGEPIFHYMGTSTFSEYTVLPEISVAKIDKQAPLEKVCLLGCGVTTGIGAVL
CCCEEEEECCCEEEEECCCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHHHH
NTAKVKPGDTVAIFGLGGIGLSALIGAVKAKAARIIAIDINPAKFEIAKQLGATDCVNPK
HCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCCCCCCH
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALESCHKGWGESVIIGVAGAGQEIATR
HHHHHHHHHHEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCC
PFQLVTGRVWRGSAFGGVRGRTELPSYVDMAQTGEIPLDTFITHTMGLEGINKAFDLMHE
CHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHC
GKSIRTVIHF
CCCEEEEECC
>Mature Secondary Structure
MIKSRAAVAFEAKKPLEIVEVDVAMPKAGEVLLRVVASGVCHTDAYTLSGADPEGIFPSI
CCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHH
LGHEGGAIVEAVGEGVTSVVVGDHVIPLYTPECRQCKFCRSGKTNLCQAIRATQGKGLMP
HCCCCCHHHHHHHCCCEEEEECCEEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DGTTRFSYKGEPIFHYMGTSTFSEYTVLPEISVAKIDKQAPLEKVCLLGCGVTTGIGAVL
CCCEEEEECCCEEEEECCCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHHHHHHHHH
NTAKVKPGDTVAIFGLGGIGLSALIGAVKAKAARIIAIDINPAKFEIAKQLGATDCVNPK
HCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCCCCCCH
DFDRPIQEVIVDMTDGGVDFSFECIGNVQLMRAALESCHKGWGESVIIGVAGAGQEIATR
HHHHHHHHHHEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCC
PFQLVTGRVWRGSAFGGVRGRTELPSYVDMAQTGEIPLDTFITHTMGLEGINKAFDLMHE
CHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHC
GKSIRTVIHF
CCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]