Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 66044590

GI number: 66044590

Start: 1522121

End: 1522903

Strand: Reverse

Name: map [H]

Synonym: Psyr_1342

Alternate gene names: 66044590

Gene position: 1522903-1522121 (Counterclockwise)

Preceding gene: 66044614

Following gene: 66044589

Centisome position: 24.99

GC content: 57.85

Gene sequence:

>783_bases
ATGACCATCACCCTCAAAACCCCGGAAGACATCGAGAAGATGCGCATCGCCGGTCGCCTGGCCGCCGATGTTCTGGAAAT
GATAGCGCCGTACGTCAAGCCCGGTGTGACCACCGAAGAGCTGGACCGCCTTTGCCATGACTATATTGTCAACGAACAGA
AGGCGATCCCGGCCCCGCTGAACTACAAGGGCTTTCCCAAATCGATCTGCACCTCGATCAACCAGGTGGTCTGCCACGGT
ATCCCGAGCGACAAGAAGCTGAAGGACGGTGACTCGCTGAACATCGACGTTACCGTCATCAAGGACGGCTACCATGGCGA
CACCAGCAGGATGTTCCATGTCGGCACCGTTCCGGTATGGGCCGAGCGCCTGTCGAAGGTAACTCAGGAGTGCCTGTACA
AGGCCATCGAAATCGTCAAACCCGGCACTCGCCTGGGTGACATCGGTGCCGTCATCCAGAAACACGCTGAAAAGAACGGC
TTCTCCGTGGTTCGTGAGTTCTGCGGCCATGGCATCGGCAAGGTGTTTCATGAAGAGCCGCAGGTGATGCACTTTGGCGA
GGCCGGAACCGGTATCGAGTTGCAGGAAGGCATGACCTTCACCATCGAACCGATGATCAACCAGGGTCGCCCTGAAACCA
AGATTCTCGGCGATGGCTGGACGGCGATCACCAAGGACCGCAAGCTCTCGGCGCAATGGGAGCACACGCTGCTGGTGACC
GCTGACGGTTACGAAATCTTCACCTTGCGCAGCGATGACACCATTGCCCAAAAGGCTCCCTGA

Upstream 100 bases:

>100_bases
ACGGCCTATAGAAGGAAGCGATGATTACCCGGCACCGGTGGTCTGATAGAATTGCGCCTTTGCGCACCCACCGCGTGCCT
GCCACGCCGAGAGAATTCGT

Downstream 100 bases:

>100_bases
CCCGATCATGCCCGGCTGAACGCCCGCCCGTCACCTGCACAGCCCGACACGAGGAATACTGCTCAATGCCGCAAGTAGAT
CCAGACTTGTTCGATCGAGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTITLKTPEDIEKMRIAGRLAADVLEMIAPYVKPGVTTEELDRLCHDYIVNEQKAIPAPLNYKGFPKSICTSINQVVCHG
IPSDKKLKDGDSLNIDVTVIKDGYHGDTSRMFHVGTVPVWAERLSKVTQECLYKAIEIVKPGTRLGDIGAVIQKHAEKNG
FSVVREFCGHGIGKVFHEEPQVMHFGEAGTGIELQEGMTFTIEPMINQGRPETKILGDGWTAITKDRKLSAQWEHTLLVT
ADGYEIFTLRSDDTIAQKAP

Sequences:

>Translated_260_residues
MTITLKTPEDIEKMRIAGRLAADVLEMIAPYVKPGVTTEELDRLCHDYIVNEQKAIPAPLNYKGFPKSICTSINQVVCHG
IPSDKKLKDGDSLNIDVTVIKDGYHGDTSRMFHVGTVPVWAERLSKVTQECLYKAIEIVKPGTRLGDIGAVIQKHAEKNG
FSVVREFCGHGIGKVFHEEPQVMHFGEAGTGIELQEGMTFTIEPMINQGRPETKILGDGWTAITKDRKLSAQWEHTLLVT
ADGYEIFTLRSDDTIAQKAP
>Mature_259_residues
TITLKTPEDIEKMRIAGRLAADVLEMIAPYVKPGVTTEELDRLCHDYIVNEQKAIPAPLNYKGFPKSICTSINQVVCHGI
PSDKKLKDGDSLNIDVTVIKDGYHGDTSRMFHVGTVPVWAERLSKVTQECLYKAIEIVKPGTRLGDIGAVIQKHAEKNGF
SVVREFCGHGIGKVFHEEPQVMHFGEAGTGIELQEGMTFTIEPMINQGRPETKILGDGWTAITKDRKLSAQWEHTLLVTA
DGYEIFTLRSDDTIAQKAP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=51.2, Blast_Score=262, Evalue=2e-70,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=44.5344129554656, Blast_Score=221, Evalue=7e-58,
Organism=Escherichia coli, GI1786364, Length=256, Percent_Identity=66.796875, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1788728, Length=208, Percent_Identity=26.4423076923077, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=48.995983935743, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=45.0199203187251, Blast_Score=232, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=50, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24583427, Length=250, Percent_Identity=46, Blast_Score=231, Evalue=4e-61,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28817; Mature: 28686

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITLKTPEDIEKMRIAGRLAADVLEMIAPYVKPGVTTEELDRLCHDYIVNEQKAIPAPL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
NYKGFPKSICTSINQVVCHGIPSDKKLKDGDSLNIDVTVIKDGYHGDTSRMFHVGTVPVW
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCHHH
AERLSKVTQECLYKAIEIVKPGTRLGDIGAVIQKHAEKNGFSVVREFCGHGIGKVFHEEP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCC
QVMHFGEAGTGIELQEGMTFTIEPMINQGRPETKILGDGWTAITKDRKLSAQWEHTLLVT
CEEEECCCCCCEEECCCCEEEEEECCCCCCCCCEEECCCCEEEECCCCCCCCCCEEEEEE
ADGYEIFTLRSDDTIAQKAP
ECCEEEEEEECCCCHHCCCC
>Mature Secondary Structure 
TITLKTPEDIEKMRIAGRLAADVLEMIAPYVKPGVTTEELDRLCHDYIVNEQKAIPAPL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
NYKGFPKSICTSINQVVCHGIPSDKKLKDGDSLNIDVTVIKDGYHGDTSRMFHVGTVPVW
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCHHH
AERLSKVTQECLYKAIEIVKPGTRLGDIGAVIQKHAEKNGFSVVREFCGHGIGKVFHEEP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCC
QVMHFGEAGTGIELQEGMTFTIEPMINQGRPETKILGDGWTAITKDRKLSAQWEHTLLVT
CEEEECCCCCCEEECCCCEEEEEECCCCCCCCCEEECCCCEEEECCCCCCCCCCEEEEEE
ADGYEIFTLRSDDTIAQKAP
ECCEEEEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]