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The map label for this gene is guaA [H]

Identifier: 66044510

GI number: 66044510

Start: 1419709

End: 1421286

Strand: Direct

Name: guaA [H]

Synonym: Psyr_1262

Alternate gene names: 66044510

Gene position: 1419709-1421286 (Clockwise)

Preceding gene: 66044509

Following gene: 66044511

Centisome position: 23.3

GC content: 61.09

Gene sequence:

>1578_bases
ATGGCCCTCGACATTCACGCCCACCGTATCCTGATCCTCGACTTCGGTTCCCAGTACACCCAGCTGATCGCCCGCCGCGT
GCGCGAAATCGGCGTGTATTGCGAGCTGCATCCGTTTGACATGGACGACGAAGCGATTCGCGAATTCGCTCCAAAAGGCG
TGGTCCTCGCCGGCGGCCCCGAGTCCGTACACGAAGCCGACAGCCCGCGCTGCCCGCAAGCGGTATTTGACCTGGGTGTG
CCGGTTTTCGGTATCTGCTACGGCATGCAGACCATGGCCGAGCAGTTGGGCGGCAAGGTTGCCGGTTCCGAGTTGCGCGA
GTTCGGCTACGCTCGCGTTGACGTAGTTGGCAAAAGCCGTCTGCTCGATGGTATCGAAGACCATATCGACGCCGACGGCC
TGTTTGGCCTCGACGTATGGATGAGTCACGGTGACAAGGTCACCAAACTGCCGGAAAACTTCCACATTCTGGCCAGCACC
CCGAGCTGCCCGATTGCCGGTATGGCTGACGACGCTCGCGGTTACTACGGCGTGCAGTTCCACCCGGAAGTGACCCACAC
CAAGCAGGGCGGTCGCATCCTGTCGCGCTTCATCCTCGACATCTGCGGCTGTGAAGCACTGTGGACCCCTTCGAAGATTG
CTGAAGACGCTATCGCTCAGGTTCGCGCTCAGGTGGGTACTGACAACGTGTTGCTGGGCCTGTCCGGCGGCGTTGACTCT
TCTGTCGTTGCCGCGTTGCTGCACAAGGCCATCGGCGATCAACTGACCTGCGTATTCGTCGACAACGGTCTGCTGCGCCT
GCACGAAGGCGAACAGGTGATGGCCATGTTCGCCGAGAACATGGGCGTCAAGGTGATCCGCGCCAACGCCGAAGAGCAGT
TCCTGAACAACCTGGCAGGCGAGAGCGATCCAGAGAAAAAGCGCAAGATCATCGGCCGCACCTTCATCGACGTGTTCGAT
GCCGAGTCCTGCAAGCTGGACAACATCAAGTACCTGGCGCAAGGCACCATCTACCCTGACGTCATCGAGTCGGCTGGCGC
GAAAAGCGGCAAGGCCCACGTCATCAAGTCGCACCACAACGTGGGCGGCCTGCCGGAAGAAATGAACCTCAAGCTGGTCG
AGCCACTGCGCGAGCTGTTCAAGGACGAAGTCCGCCGCCTGGGCCTCGAACTCGGCCTGCCCTACGACATGGTCTACCGC
CACCCATTCCCAGGCCCAGGCCTGGGCGTGCGCATCCTCGGCGAAGTGAAGAAGGAATACGCCGACCTCCTGCGTCGTGC
CGACCACATCTTCATCGAAGAACTGCGCAAGGCCGACTGGTACCACAAGGTCAGCCAGGCGTTCGTAGTGTTCCAGCCGG
TCAAATCAGTCGGCGTCGTCGGCGACGGCCGCCGCTACGCCTGGGTTGTCGCGTTGCGTGCGGTGGAAACCATCGACTTC
ATGACCGCTCGCTGGGCGCATCTGCCTTATGAGCTGCTGGAGACGGTGAGCGGCCGGATCATCAACGAGATCGAAGGGAT
TTCGCGGGTGACTTATGACGTGTCGAGCAAGCCGCCGGCTACTATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CAATCAGCTACAAGCGGTAGTTACGCAAGTGTAACTACCGCATTGATTCCGACAACTTGCCGCTTGCAGCGTATAGCTTG
CAGCTGCTCAGAGAGTTTCC

Downstream 100 bases:

>100_bases
TCCCACAGTGCTGCATGGCTGCATGAAAGAACCGGCTTTGGCCGGTTTTTTCATGCCCGCACTAATGGCTTATTCTCGCT
ATTGAAAGAGCCGCATTGCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVVLAGGPESVHEADSPRCPQAVFDLGV
PVFGICYGMQTMAEQLGGKVAGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKLPENFHILAST
PSCPIAGMADDARGYYGVQFHPEVTHTKQGGRILSRFILDICGCEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEEQFLNNLAGESDPEKKRKIIGRTFIDVFD
AESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE

Sequences:

>Translated_525_residues
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVVLAGGPESVHEADSPRCPQAVFDLGV
PVFGICYGMQTMAEQLGGKVAGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKLPENFHILAST
PSCPIAGMADDARGYYGVQFHPEVTHTKQGGRILSRFILDICGCEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEEQFLNNLAGESDPEKKRKIIGRTFIDVFD
AESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
>Mature_524_residues
ALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVVLAGGPESVHEADSPRCPQAVFDLGVP
VFGICYGMQTMAEQLGGKVAGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKLPENFHILASTP
SCPIAGMADDARGYYGVQFHPEVTHTKQGGRILSRFILDICGCEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDSS
VVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEEQFLNNLAGESDPEKKRKIIGRTFIDVFDA
ESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRH
PFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDFM
TARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=528, Percent_Identity=36.3636363636364, Blast_Score=303, Evalue=3e-82,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=71.0476190476191, Blast_Score=790, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=35.304347826087, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=35.304347826087, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=35.304347826087, Blast_Score=297, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=49.7142857142857, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI281365319, Length=554, Percent_Identity=34.115523465704, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58072; Mature: 57941

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVVLAGGP
CEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHCCCCEEEECCC
ESVHEADSPRCPQAVFDLGVPVFGICYGMQTMAEQLGGKVAGSELREFGYARVDVVGKSR
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCHHH
LLDGIEDHIDADGLFGLDVWMSHGDKVTKLPENFHILASTPSCPIAGMADDARGYYGVQF
HHHHHHHHCCCCCEEEHHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCEEEEEE
HPEVTHTKQGGRILSRFILDICGCEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDS
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEEQFLNNLAG
HHHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHCC
ESDPEKKRKIIGRTFIDVFDAESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEY
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
ADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHCCCCCCCCCEEEHHHHHHHHHHHH
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC
>Mature Secondary Structure 
ALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDDEAIREFAPKGVVLAGGP
EEEEEEEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHCCCCEEEECCC
ESVHEADSPRCPQAVFDLGVPVFGICYGMQTMAEQLGGKVAGSELREFGYARVDVVGKSR
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCHHH
LLDGIEDHIDADGLFGLDVWMSHGDKVTKLPENFHILASTPSCPIAGMADDARGYYGVQF
HHHHHHHHCCCCCEEEHHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCEEEEEE
HPEVTHTKQGGRILSRFILDICGCEALWTPSKIAEDAIAQVRAQVGTDNVLLGLSGGVDS
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEEQFLNNLAG
HHHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHCC
ESDPEKKRKIIGRTFIDVFDAESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEY
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
ADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHCCCCCCCCCEEEHHHHHHHHHHHH
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA