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The map label for this gene is guaB [H]

Identifier: 66044509

GI number: 66044509

Start: 1418116

End: 1419585

Strand: Direct

Name: guaB [H]

Synonym: Psyr_1261

Alternate gene names: 66044509

Gene position: 1418116-1419585 (Clockwise)

Preceding gene: 66044508

Following gene: 66044510

Centisome position: 23.27

GC content: 60.14

Gene sequence:

>1470_bases
ATGCTGCGTATCAGTCAAGAAGCCCTTACATTCGACGACATTCTCCTTGTGCCCGGTTATTCCGAGGTACTCCCTAACGA
AGTCAGTCTGAAAACCCGTTTGACCCGTGGCATCGAGCTGAATATACCTTTGGTCTCTGCTGCAATGGATACTGTCACCG
AGGCCCGTCTGGCAATTGCCATGGCCCAGGAAGGCGGTATCGGTATCATCCACAAGAACATGACCATCGAGCAGCAAGCT
GCCGAAGTGCGCAAGGTCAAGAAGTTCGAGGCCGGTGTCGTCAAGGACCCGATCACGATCGAAGCCGACGCCACTGTTCG
CGATCTGTTCGAACTCACCCGCATGCACAACATTTCCGGCGTACCGGTCCTGCACAATGGCGACCTGGTCGGCATCGTGA
CGTCCCGCGACGTACGCTTCGAAAACCGTCTTGATGTCCCTGTCCGCGAAGTGATGACGCCCAAAGAGCGTCTGGTCACC
GTGCGCGAAGGCGCCGACAAGAACGAAGTGCGCGAACTGCTGCACAAGCACCGTCTTGAAAAAGTCCTGATCGTGGATGC
CAATTTCGCGCTCAAGGGCATGATGACCGTCAAGGACATCGAAAAAGCCAAGGCTTATCCGCTGGCCAGCAAGGACGATC
AGGCTCGCCTGCGTGTCGGCGCTGCAGTCGGTACCGGCAAGGACACCGGCGAGCGCGTCACCGCACTGGTCGCGGCTGGC
GTTGATGTTGTTGTCGTCGACACCGCTCACGGCCATTCCAAAGGCGTGATCGACCGCGTCCGCTGGGTCAAGGAAAACTT
CCCTCAGGTGCAGGTCATCGGTGGCAACATCGCCACTGGCGAAGCGGCCAGGGCACTGGTTGCCGCAGGCGCCGATGCAG
TCAAGGTCGGTATCGGCCCGGGCTCCATCTGCACCACGCGTATCGTTGCCGGTGTCGGCGTGCCGCAGATCAGCGCCATC
GCCAACGTTTCCGCTGCCCTTGAAGGCACTGGCGTGCCGATGATCGCCGACGGCGGTATCCGCTTCTCCGGTGACCTGTC
CAAGGCCATCGTGGCTGGCGCCTCCTGCGTGATGATGGGCTCGATGTTCGCCGGTACTGAAGAAGCGCCAGGCGAGATCG
AACTGTTTCAGGGCCGTTCCTACAAGGCCTATCGCGGCATGGGTTCGCTGGGTGCGATGTCCCAGGCGCAAGGCTCTTCC
GATCGCTACTTCCAGGATTCCTCCGCCGGTGCCGAGAAGCTGGTGCCGGAAGGTATCGAAGGCCGTGTGGCCTATAAAGG
TCCGTTGTCGGCCATCATCCATCAGTTGATGGGCGGCCTGCGTTCCTCCATGGGTTACACCGGCAGTGCCGACATCGAGC
AGATGCGCACCAAGCCAGAGTTCGTTCGCATCACCGGTGCCGGTATGGCTGAGTCCCACGTCCATGACGTGCAGATCACC
AAGGAAGCGCCGAACTATCGCGTCGGCTAA

Upstream 100 bases:

>100_bases
CTATAAACAGCTTTGATAATAGGCTGAGGTTTACATTGAGCCGGGAGGGGTCTGTGGGTATAATGGCGCGCTTCCAATTT
CCCGCCCGGGAGCCCCCGCG

Downstream 100 bases:

>100_bases
AACCTCCAGCTTCAAGCCCCAAGCAATCAGCTACAAGCGGTAGTTACGCAAGTGTAACTACCGCATTGATTCCGACAACT
TGCCGCTTGCAGCGTATAGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMTIEQQA
AEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISGVPVLHNGDLVGIVTSRDVRFENRLDVPVREVMTPKERLVT
VREGADKNEVRELLHKHRLEKVLIVDANFALKGMMTVKDIEKAKAYPLASKDDQARLRVGAAVGTGKDTGERVTALVAAG
VDVVVVDTAHGHSKGVIDRVRWVKENFPQVQVIGGNIATGEAARALVAAGADAVKVGIGPGSICTTRIVAGVGVPQISAI
ANVSAALEGTGVPMIADGGIRFSGDLSKAIVAGASCVMMGSMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSS
DRYFQDSSAGAEKLVPEGIEGRVAYKGPLSAIIHQLMGGLRSSMGYTGSADIEQMRTKPEFVRITGAGMAESHVHDVQIT
KEAPNYRVG

Sequences:

>Translated_489_residues
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMTIEQQA
AEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISGVPVLHNGDLVGIVTSRDVRFENRLDVPVREVMTPKERLVT
VREGADKNEVRELLHKHRLEKVLIVDANFALKGMMTVKDIEKAKAYPLASKDDQARLRVGAAVGTGKDTGERVTALVAAG
VDVVVVDTAHGHSKGVIDRVRWVKENFPQVQVIGGNIATGEAARALVAAGADAVKVGIGPGSICTTRIVAGVGVPQISAI
ANVSAALEGTGVPMIADGGIRFSGDLSKAIVAGASCVMMGSMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSS
DRYFQDSSAGAEKLVPEGIEGRVAYKGPLSAIIHQLMGGLRSSMGYTGSADIEQMRTKPEFVRITGAGMAESHVHDVQIT
KEAPNYRVG
>Mature_489_residues
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMTIEQQA
AEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISGVPVLHNGDLVGIVTSRDVRFENRLDVPVREVMTPKERLVT
VREGADKNEVRELLHKHRLEKVLIVDANFALKGMMTVKDIEKAKAYPLASKDDQARLRVGAAVGTGKDTGERVTALVAAG
VDVVVVDTAHGHSKGVIDRVRWVKENFPQVQVIGGNIATGEAARALVAAGADAVKVGIGPGSICTTRIVAGVGVPQISAI
ANVSAALEGTGVPMIADGGIRFSGDLSKAIVAGASCVMMGSMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSS
DRYFQDSSAGAEKLVPEGIEGRVAYKGPLSAIIHQLMGGLRSSMGYTGSADIEQMRTKPEFVRITGAGMAESHVHDVQIT
KEAPNYRVG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=42.1487603305785, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI217035146, Length=485, Percent_Identity=42.2680412371134, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=43.2900432900433, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=43.2900432900433, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=43.2900432900433, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=43.4589800443459, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI217035148, Length=485, Percent_Identity=41.2371134020619, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI217035150, Length=485, Percent_Identity=38.7628865979381, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=35.7692307692308, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541954, Length=260, Percent_Identity=36.1538461538462, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI50541952, Length=260, Percent_Identity=36.1538461538462, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI50541948, Length=260, Percent_Identity=36.1538461538462, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI50541956, Length=260, Percent_Identity=36.1538461538462, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=66.734693877551, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1786293, Length=348, Percent_Identity=30.4597701149425, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=502, Percent_Identity=38.0478087649402, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=41.4691943127962, Blast_Score=291, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=286, Percent_Identity=32.1678321678322, Blast_Score=164, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=41.5289256198347, Blast_Score=345, Evalue=7e-96,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=41.1157024793388, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=41.7355371900826, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=42.0118343195266, Blast_Score=263, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=102, Percent_Identity=43.1372549019608, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=42.0289855072464, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=42.0289855072464, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.9501133786848, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52002; Mature: 52002

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEECCCHHHHCCCCCEEHHHHCCCEEECCCHHHHHHHHHHHHHHEEE
MAQEGGIGIIHKNMTIEQQAAEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
VPVLHNGDLVGIVTSRDVRFENRLDVPVREVMTPKERLVTVREGADKNEVRELLHKHRLE
CEEEECCCEEEEEECCCCCCCCCCCCCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHCCC
KVLIVDANFALKGMMTVKDIEKAKAYPLASKDDQARLRVGAAVGTGKDTGERVTALVAAG
EEEEEECCCCEECCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCC
VDVVVVDTAHGHSKGVIDRVRWVKENFPQVQVIGGNIATGEAARALVAAGADAVKVGIGP
CEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQISAIANVSAALEGTGVPMIADGGIRFSGDLSKAIVAGASCVMMG
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCEEECCCHHHHHHHCCHHHHHH
SMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSSDRYFQDSSAGAEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCHHCCCCCCCEECCCCCCHHHHCCCCCC
GRVAYKGPLSAIIHQLMGGLRSSMGYTGSADIEQMRTKPEFVRITGAGMAESHVHDVQIT
CEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEEEEE
KEAPNYRVG
CCCCCCCCC
>Mature Secondary Structure
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEECCCHHHHCCCCCEEHHHHCCCEEECCCHHHHHHHHHHHHHHEEE
MAQEGGIGIIHKNMTIEQQAAEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
VPVLHNGDLVGIVTSRDVRFENRLDVPVREVMTPKERLVTVREGADKNEVRELLHKHRLE
CEEEECCCEEEEEECCCCCCCCCCCCCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHCCC
KVLIVDANFALKGMMTVKDIEKAKAYPLASKDDQARLRVGAAVGTGKDTGERVTALVAAG
EEEEEECCCCEECCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCC
VDVVVVDTAHGHSKGVIDRVRWVKENFPQVQVIGGNIATGEAARALVAAGADAVKVGIGP
CEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQISAIANVSAALEGTGVPMIADGGIRFSGDLSKAIVAGASCVMMG
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCEEECCCHHHHHHHCCHHHHHH
SMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSSDRYFQDSSAGAEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCHHCCCCCCCEECCCCCCHHHHCCCCCC
GRVAYKGPLSAIIHQLMGGLRSSMGYTGSADIEQMRTKPEFVRITGAGMAESHVHDVQIT
CEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEEEEE
KEAPNYRVG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA