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The map label for this gene is ndk

Identifier: 66044492

GI number: 66044492

Start: 1399945

End: 1400370

Strand: Direct

Name: ndk

Synonym: Psyr_1244

Alternate gene names: 66044492

Gene position: 1399945-1400370 (Clockwise)

Preceding gene: 66044491

Following gene: 66044493

Centisome position: 22.97

GC content: 56.57

Gene sequence:

>426_bases
ATGGCTGTTCAACGTACTTTCTCCATCATCAAGCCTGACGCCGTTGCCAAGAACGTAATCGGCGAGATCACCACTCGTTT
CGAAAAAGCCGGTCTGCGCGTTGTCGCTTCCAAGCTGAAGCAACTGTCCAAGGCCGAAGCTGAAGGTTTCTACGCTGAGC
ACAGCGCTCGCGGTTTCTTCGGCGACCTGGTTGCTTTCATGATCTCCGGTCCGGTTGTCGTTCAGGTTCTGGAAGGCGAA
AACGCTATCGCTCTGAACCGTGAGCTGATGGGCGCTACCAACCCTAAAGAAGCGGCTGCCGGCACCATCCGTGCTGACTT
CGCTGACTCCATCGACGCCAACGCTGTTCACGGCTCCGATTCCGAAGCAGCCGCCGCTCGCGAAATCTCGTACTTCTTCG
CAGCTACCGAAGTAACCGCTCGCTAA

Upstream 100 bases:

>100_bases
TTGACGTTCAGTAACGCGCGCAGTTAGGCAATACACCAGAACCCGCGTATAATTCGCGGGTTTAATTTTTCGCTTCAATC
ACTGCTTCTGGAGTTTCACC

Downstream 100 bases:

>100_bases
GTCATTTTTGACTGACGAGTGAAGGGTGAATTCATGATTGCATCGACTGGTAAAACCAACCTGCTGGGGCTGACTCAACA
GGAAATGGAGAAATTCTTCG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAVQRTFSIIKPDAVAKNVIGEITTRFEKAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGDLVAFMISGPVVVQVLEGE
NAIALNRELMGATNPKEAAAGTIRADFADSIDANAVHGSDSEAAAAREISYFFAATEVTAR

Sequences:

>Translated_141_residues
MAVQRTFSIIKPDAVAKNVIGEITTRFEKAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGDLVAFMISGPVVVQVLEGE
NAIALNRELMGATNPKEAAAGTIRADFADSIDANAVHGSDSEAAAAREISYFFAATEVTAR
>Mature_140_residues
AVQRTFSIIKPDAVAKNVIGEITTRFEKAGLRVVASKLKQLSKAEAEGFYAEHSARGFFGDLVAFMISGPVVVQVLEGEN
AIALNRELMGATNPKEAAAGTIRADFADSIDANAVHGSDSEAAAAREISYFFAATEVTAR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=139, Percent_Identity=46.0431654676259, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=43.0656934306569, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=43.0656934306569, Blast_Score=123, Evalue=4e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=43.0656934306569, Blast_Score=123, Evalue=4e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=43.0656934306569, Blast_Score=123, Evalue=4e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=43.0656934306569, Blast_Score=123, Evalue=4e-29,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=42.6470588235294, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=42.3357664233577, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=37.2262773722628, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=36.7647058823529, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=36.7647058823529, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=37.956204379562, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=37.037037037037, Blast_Score=86, Evalue=8e-18,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.1167883211679, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=60.9929078014184, Blast_Score=181, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=41.9117647058824, Blast_Score=116, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=42.962962962963, Blast_Score=124, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=44.4444444444444, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18860097, Length=131, Percent_Identity=35.1145038167939, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PSE14 (Q48LZ8)

Other databases:

- EMBL:   CP000058
- RefSeq:   YP_273574.1
- ProteinModelPortal:   Q48LZ8
- SMR:   Q48LZ8
- STRING:   Q48LZ8
- World-2DPAGE:   0008:Q48LZ8
- GeneID:   3559360
- GenomeReviews:   CP000058_GR
- KEGG:   psp:PSPPH_1316
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q48LZ8
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 14951; Mature: 14820

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQRTFSIIKPDAVAKNVIGEITTRFEKAGLRVVASKLKQLSKAEAEGFYAEHSARGFF
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHH
GDLVAFMISGPVVVQVLEGENAIALNRELMGATNPKEAAAGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCEEEECHHHHCCCCCCHHHCCCHHHCCCCCCCCCCCCCCC
SEAAAAREISYFFAATEVTAR
CHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVQRTFSIIKPDAVAKNVIGEITTRFEKAGLRVVASKLKQLSKAEAEGFYAEHSARGFF
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHH
GDLVAFMISGPVVVQVLEGENAIALNRELMGATNPKEAAAGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCEEEECHHHHCCCCCCHHHCCCHHHCCCCCCCCCCCCCCC
SEAAAAREISYFFAATEVTAR
CHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA