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The map label for this gene is yogA [H]

Identifier: 66044404

GI number: 66044404

Start: 1304459

End: 1305469

Strand: Direct

Name: yogA [H]

Synonym: Psyr_1153

Alternate gene names: 66044404

Gene position: 1304459-1305469 (Clockwise)

Preceding gene: 66044403

Following gene: 66044405

Centisome position: 21.41

GC content: 60.63

Gene sequence:

>1011_bases
ATGAGCAATACAACCATCTATGTGCAGGCTGGCGGCGGCTACGATCAGGTCAGCGTGGGCGAAAGCGAAGTGCTTGCACC
GAAAGCCGGTGAGATCACTGTGCGTCTGCACGCCAACTCGCTCAACTATCACGACTTTGCGGTCGTCACCGGCATGTGGG
CACCAACGGAAAAACGCATTCCCATGGCCGATGGTGCAGGCGTAGTCACCGCAGTAGGCGAGGGCGTCAGCGAGTTCGCG
GTTGGCGACTCCGTGGTCAGCACGTTCTTCCCGGAATGGATCAGCGGCGAGCCGCTGGTTGAAGGTTTTGTCACGGTGCC
GGGTGATGGCGTCGACGGTTATGCCCGTGAGCAGGTGACTGCCCGTGCTACCTCGTTCACCCTGGCGCCAAAGGGCTACA
GCCATGCCGAAGCGTCCACGCTGACCACCGCTGGCCTGACCGCATGGCGTGCGCTGATGGTCGATGACGCGTTGAAAGCC
GGCGATACCGTTCTGGTACAGGGCACTGGCGGTGTATCGATTTTCGCGCTGCAATTCGCCAAGATGGTCGGTGCGACCGT
TATCGCGACGTCGTCGAGTGATGAAAAGCTGGAGCGTCTGCAAGCCATGGGCGCCGACCACCTGATCAACTACCGCAAGG
ACAGCAACTGGGGCGAGACTGCCCGCAAGCTGACCGGCGGCCGTGGTGTTGATCACATCATCGACGTGGGCGGTCCATCG
ACCCTGCAGCATTCCATGAATGCGGCACGGGTCGCTGGGCACATCTCGGTCATCGGCATTCTGAGCGGTGTTGCCGGTCA
ACTGGAGTTCGTCCCGGCGCTGGTCAAACAGCTGCGCATGCAGGGCGTGCTGGTCGGCAGTCGCACCCAGCAACAGGACA
TGATCCGTGCCATTGATGCCAACGGCATGCGTCCGGTCATGGACCGTTCCTTCCCGATGACCGACATCGTCGAAGCGTTC
CGTTATCAGGAAACCAATCAGCATTTCGGCAAGATCTGCCTGGATATCTGA

Upstream 100 bases:

>100_bases
CGACCGGTTTGCCGACAGGCTCAAGAAAGAACTCTAGGCTTTGAGCGTTATTTATACATTTCGTCATTTTGCGTAATGTT
GAATTGATAGGAGATTGACC

Downstream 100 bases:

>100_bases
TCCGCAACACTGTGCTGTTAACTGAGCACAGGTGAACAGCGCTGGCCTGCCGACCCTGGTGTCGGCGGGCCAGTCGTGAA
GTCTTGCATTACTTTCCTTG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: Glycerol; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSNTTIYVQAGGGYDQVSVGESEVLAPKAGEITVRLHANSLNYHDFAVVTGMWAPTEKRIPMADGAGVVTAVGEGVSEFA
VGDSVVSTFFPEWISGEPLVEGFVTVPGDGVDGYAREQVTARATSFTLAPKGYSHAEASTLTTAGLTAWRALMVDDALKA
GDTVLVQGTGGVSIFALQFAKMVGATVIATSSSDEKLERLQAMGADHLINYRKDSNWGETARKLTGGRGVDHIIDVGGPS
TLQHSMNAARVAGHISVIGILSGVAGQLEFVPALVKQLRMQGVLVGSRTQQQDMIRAIDANGMRPVMDRSFPMTDIVEAF
RYQETNQHFGKICLDI

Sequences:

>Translated_336_residues
MSNTTIYVQAGGGYDQVSVGESEVLAPKAGEITVRLHANSLNYHDFAVVTGMWAPTEKRIPMADGAGVVTAVGEGVSEFA
VGDSVVSTFFPEWISGEPLVEGFVTVPGDGVDGYAREQVTARATSFTLAPKGYSHAEASTLTTAGLTAWRALMVDDALKA
GDTVLVQGTGGVSIFALQFAKMVGATVIATSSSDEKLERLQAMGADHLINYRKDSNWGETARKLTGGRGVDHIIDVGGPS
TLQHSMNAARVAGHISVIGILSGVAGQLEFVPALVKQLRMQGVLVGSRTQQQDMIRAIDANGMRPVMDRSFPMTDIVEAF
RYQETNQHFGKICLDI
>Mature_335_residues
SNTTIYVQAGGGYDQVSVGESEVLAPKAGEITVRLHANSLNYHDFAVVTGMWAPTEKRIPMADGAGVVTAVGEGVSEFAV
GDSVVSTFFPEWISGEPLVEGFVTVPGDGVDGYAREQVTARATSFTLAPKGYSHAEASTLTTAGLTAWRALMVDDALKAG
DTVLVQGTGGVSIFALQFAKMVGATVIATSSSDEKLERLQAMGADHLINYRKDSNWGETARKLTGGRGVDHIIDVGGPST
LQHSMNAARVAGHISVIGILSGVAGQLEFVPALVKQLRMQGVLVGSRTQQQDMIRAIDANGMRPVMDRSFPMTDIVEAFR
YQETNQHFGKICLDI

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=350, Percent_Identity=27.4285714285714, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI22538444, Length=350, Percent_Identity=27.4285714285714, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI194239674, Length=304, Percent_Identity=27.3026315789474, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13236495, Length=304, Percent_Identity=27.3026315789474, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI47519420, Length=348, Percent_Identity=25.8620689655172, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI18379349, Length=352, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI194239676, Length=210, Percent_Identity=29.5238095238095, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI87081918, Length=318, Percent_Identity=27.0440251572327, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790485, Length=264, Percent_Identity=26.8939393939394, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=255, Percent_Identity=27.0588235294118, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=24.8484848484848, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319520, Length=346, Percent_Identity=25.7225433526012, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=24.5454545454545, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=24.5454545454545, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=335, Percent_Identity=23.8805970149254, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19920632, Length=221, Percent_Identity=25.7918552036199, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330659, Length=221, Percent_Identity=25.7918552036199, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581345, Length=221, Percent_Identity=25.7918552036199, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1 [C]

Molecular weight: Translated: 35664; Mature: 35533

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTTIYVQAGGGYDQVSVGESEVLAPKAGEITVRLHANSLNYHDFAVVTGMWAPTEKRI
CCCCEEEEEECCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCC
PMADGAGVVTAVGEGVSEFAVGDSVVSTFFPEWISGEPLVEGFVTVPGDGVDGYAREQVT
CCCCCCCEEEHHCCCHHHHHHHHHHHHHHCHHHCCCCHHHCCEEECCCCCCCCHHHHHHH
ARATSFTLAPKGYSHAEASTLTTAGLTAWRALMVDDALKAGDTVLVQGTGGVSIFALQFA
HHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
KMVGATVIATSSSDEKLERLQAMGADHLINYRKDSNWGETARKLTGGRGVDHIIDVGGPS
HHHCCEEEEECCCHHHHHHHHHCCHHHHEECCCCCCHHHHHHHHCCCCCCCCEEECCCCH
TLQHSMNAARVAGHISVIGILSGVAGQLEFVPALVKQLRMQGVLVGSRTQQQDMIRAIDA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHCC
NGMRPVMDRSFPMTDIVEAFRYQETNQHFGKICLDI
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure 
SNTTIYVQAGGGYDQVSVGESEVLAPKAGEITVRLHANSLNYHDFAVVTGMWAPTEKRI
CCCEEEEEECCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCC
PMADGAGVVTAVGEGVSEFAVGDSVVSTFFPEWISGEPLVEGFVTVPGDGVDGYAREQVT
CCCCCCCEEEHHCCCHHHHHHHHHHHHHHCHHHCCCCHHHCCEEECCCCCCCCHHHHHHH
ARATSFTLAPKGYSHAEASTLTTAGLTAWRALMVDDALKAGDTVLVQGTGGVSIFALQFA
HHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
KMVGATVIATSSSDEKLERLQAMGADHLINYRKDSNWGETARKLTGGRGVDHIIDVGGPS
HHHCCEEEEECCCHHHHHHHHHCCHHHHEECCCCCCHHHHHHHHCCCCCCCCEEECCCCH
TLQHSMNAARVAGHISVIGILSGVAGQLEFVPALVKQLRMQGVLVGSRTQQQDMIRAIDA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHCC
NGMRPVMDRSFPMTDIVEAFRYQETNQHFGKICLDI
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.005 {cyclohexanol}} 0.004 {

Substrates: D-Glyceraldehyde; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: D-Glyceraldehyde + H+ + Nicotinamide adenine dinucleotide - reduced <==> Glycerol + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]