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The map label for this gene is cyoE [H]

Identifier: 66044396

GI number: 66044396

Start: 1296293

End: 1297180

Strand: Direct

Name: cyoE [H]

Synonym: Psyr_1145

Alternate gene names: 66044396

Gene position: 1296293-1297180 (Clockwise)

Preceding gene: 66044395

Following gene: 66044397

Centisome position: 21.27

GC content: 55.97

Gene sequence:

>888_bases
ATGTCACTGAAGCACTTTATCCAAATCACCAAGCCGGGGATCATTTTCGGTAACGTGCTTTCGGTGGCAGGTGGCTTTTT
TCTGGCTTCCAAGGGAAATATCGATTTCGGCGTGTTCCTCGCTGCAGTCATCGGTACTTCCCTGGTCGTTGCGTCCGGTT
GTGTGTTCAATAACTGCATCGATCGCGATATCGATCAGCGAATGGAGAGAACCCGTAACCGGGTTCTGGTGCAGGGCCTG
GTTTCACTGAAACTGGCGCTGCTCTACGCAACCCTGCTCGGTATTGCAGGCGTTGGCCTGCTGTACACCGAGGCCAATCC
CTTGGCCGCACTGTTTGCAGTGATCGGGTTCGTGATCTACGTCGGCCTTTACAGCCTGTACCTGAAACGCAGATCCGTTC
ACGGCACGCTGGTGGGCAGTCTCTCGGGGGCCATGCCGCCGGTGATTGGCTACTGCGCAGTGAGCAACAGCTTCGACTTT
GCGGCCCTGACGCTACTGGTGATGTTCAGCCTGTGGCAGATGCCGCATTCGTATGCGATCGCCATCTTCCGCTTCAATGA
TTACCGTGCTGCGAAGATCCCGGTTCTGCCGGTCAAGCGCGGCATTCTGGTCACCAAGCGCCACATCATGCTCTACATCC
TGGCGTTCCTCGTGGCGACCCTGATGTTGACCGTCGGTGGCTATGCGGGCCTCAACTACCTGGCTGTCGCAGCGGGTATG
GGCATGTACTGGCTGTACATGGCCTGGAAGGGCTACAAGGCCGTTGACGATACTGTCTGGGCTCGCAAGCTGTTCGTGTT
TTCGATCTTCACCATTACTGCCTTGAGCGTGATGATGTCGGTCGACTTTCAGGTGACAAAAGAATTGCTGGTGACTTACG
CCTTCTGA

Upstream 100 bases:

>100_bases
TTCGCCTTTACCACGATGGTTATCGTCCTGCTGGTCGGCTTGTCGCTGTGGATCATTTTCAGCGTCCACCGCGAAATGAT
GGCGCATTGAGGAATACCAG

Downstream 100 bases:

>100_bases
TTCCACTTGATACGCGACCTGATAAACCCCGTTCTGCGAAGAACGGGGTTTTTTTTGAGTGTCGATCTACACTGGTTGAA
GGAAATGGCATGCCGATAGT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSLKHFIQITKPGIIFGNVLSVAGGFFLASKGNIDFGVFLAAVIGTSLVVASGCVFNNCIDRDIDQRMERTRNRVLVQGL
VSLKLALLYATLLGIAGVGLLYTEANPLAALFAVIGFVIYVGLYSLYLKRRSVHGTLVGSLSGAMPPVIGYCAVSNSFDF
AALTLLVMFSLWQMPHSYAIAIFRFNDYRAAKIPVLPVKRGILVTKRHIMLYILAFLVATLMLTVGGYAGLNYLAVAAGM
GMYWLYMAWKGYKAVDDTVWARKLFVFSIFTITALSVMMSVDFQVTKELLVTYAF

Sequences:

>Translated_295_residues
MSLKHFIQITKPGIIFGNVLSVAGGFFLASKGNIDFGVFLAAVIGTSLVVASGCVFNNCIDRDIDQRMERTRNRVLVQGL
VSLKLALLYATLLGIAGVGLLYTEANPLAALFAVIGFVIYVGLYSLYLKRRSVHGTLVGSLSGAMPPVIGYCAVSNSFDF
AALTLLVMFSLWQMPHSYAIAIFRFNDYRAAKIPVLPVKRGILVTKRHIMLYILAFLVATLMLTVGGYAGLNYLAVAAGM
GMYWLYMAWKGYKAVDDTVWARKLFVFSIFTITALSVMMSVDFQVTKELLVTYAF
>Mature_294_residues
SLKHFIQITKPGIIFGNVLSVAGGFFLASKGNIDFGVFLAAVIGTSLVVASGCVFNNCIDRDIDQRMERTRNRVLVQGLV
SLKLALLYATLLGIAGVGLLYTEANPLAALFAVIGFVIYVGLYSLYLKRRSVHGTLVGSLSGAMPPVIGYCAVSNSFDFA
ALTLLVMFSLWQMPHSYAIAIFRFNDYRAAKIPVLPVKRGILVTKRHIMLYILAFLVATLMLTVGGYAGLNYLAVAAGMG
MYWLYMAWKGYKAVDDTVWARKLFVFSIFTITALSVMMSVDFQVTKELLVTYAF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=170, Percent_Identity=35.8823529411765, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1786631, Length=288, Percent_Identity=68.0555555555556, Blast_Score=400, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71998235, Length=235, Percent_Identity=35.3191489361702, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325085, Length=301, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921064, Length=257, Percent_Identity=29.5719844357977, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32358; Mature: 32227

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKHFIQITKPGIIFGNVLSVAGGFFLASKGNIDFGVFLAAVIGTSLVVASGCVFNNCI
CCHHHHEEECCCCEEHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
DRDIDQRMERTRNRVLVQGLVSLKLALLYATLLGIAGVGLLYTEANPLAALFAVIGFVIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHH
VGLYSLYLKRRSVHGTLVGSLSGAMPPVIGYCAVSNSFDFAALTLLVMFSLWQMPHSYAI
HHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEE
AIFRFNDYRAAKIPVLPVKRGILVTKRHIMLYILAFLVATLMLTVGGYAGLNYLAVAAGM
EEEEECCCCEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GMYWLYMAWKGYKAVDDTVWARKLFVFSIFTITALSVMMSVDFQVTKELLVTYAF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SLKHFIQITKPGIIFGNVLSVAGGFFLASKGNIDFGVFLAAVIGTSLVVASGCVFNNCI
CHHHHEEECCCCEEHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
DRDIDQRMERTRNRVLVQGLVSLKLALLYATLLGIAGVGLLYTEANPLAALFAVIGFVIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHH
VGLYSLYLKRRSVHGTLVGSLSGAMPPVIGYCAVSNSFDFAALTLLVMFSLWQMPHSYAI
HHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEE
AIFRFNDYRAAKIPVLPVKRGILVTKRHIMLYILAFLVATLMLTVGGYAGLNYLAVAAGM
EEEEECCCCEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GMYWLYMAWKGYKAVDDTVWARKLFVFSIFTITALSVMMSVDFQVTKELLVTYAF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA