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The map label for this gene is czcR [H]

Identifier: 66044378

GI number: 66044378

Start: 1276339

End: 1277016

Strand: Reverse

Name: czcR [H]

Synonym: Psyr_1127

Alternate gene names: 66044378

Gene position: 1277016-1276339 (Counterclockwise)

Preceding gene: 66044379

Following gene: 66044377

Centisome position: 20.96

GC content: 62.09

Gene sequence:

>678_bases
ATGCGCGTGCTGATTATCGAAGACGAAGAGAAAACCGCCGACTACCTGCGTCGGGGCCTGACCGAACAGGGCTATGCCGT
GGACGTGGCGCGCGACGGGATCGAAGGCCTGCACCTGGCGCTGGAGAATGACCATGCGATCGTCATTCTCGATGTGATGC
TCCCGGGCCTGGATGGTTTTGGTGTGTTGCGTGCGTTGCGCGCGCGCAAACAGACACCCGTGATCATGCTGACCGCACGC
GAGCAGATCGACGACCGCATTCGCGGCCTGCGCGAAGGCGCGGATGATTACCTGGGCAAACCGTTTTCCTTTCTGGAACT
GGTCGCCCGTCTGCAGGCCCTGACCCGGCGCAGCGGTGGCCATGAACCGATACAGATCACCATCGCCGACCTGTGGATAG
ACCTGATCAGCCGCAAGGCGACCCGTGCCGGCCTGCGCCTGGACCTGACCGCCAAGGAGTTTTCGCTGCTCAGCGTGCTG
GCCCGACGTCAGGGCGACATTCTCTCCAAGACATCCATCGCCGAGATGGTCTGGGACATCAACTTCGACAGCGATACCAA
TGTGGTCGAAGTCGCGATCAAGCGCTTGCGGGCCAAGCTCGATGGCCCTCACGAGCACAAGCTGCTGCACACCATTCGCG
GCATGGGCTACGTGCTGGAGAACCGCAGTGCGGGTTGA

Upstream 100 bases:

>100_bases
ACCACGCCGGTCATTTATCTGCAACTGGAGCGGCTGTTTCATCGACGTCACCCGGCGCCCGACGCACCGGCGCTGGCCCT
GCACAAGTGAGAGTCACCCG

Downstream 100 bases:

>100_bases
TTCGATTGCTTTACGCCTGAGCGGGATGTTCGCGCTGGTGGCACTGGTGGTGTTCCTGCTGATCGGCTGGGCCTTGTACC
TGCAGGTCGACAAGAGCCTC

Product: heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRVLIIEDEEKTADYLRRGLTEQGYAVDVARDGIEGLHLALENDHAIVILDVMLPGLDGFGVLRALRARKQTPVIMLTAR
EQIDDRIRGLREGADDYLGKPFSFLELVARLQALTRRSGGHEPIQITIADLWIDLISRKATRAGLRLDLTAKEFSLLSVL
ARRQGDILSKTSIAEMVWDINFDSDTNVVEVAIKRLRAKLDGPHEHKLLHTIRGMGYVLENRSAG

Sequences:

>Translated_225_residues
MRVLIIEDEEKTADYLRRGLTEQGYAVDVARDGIEGLHLALENDHAIVILDVMLPGLDGFGVLRALRARKQTPVIMLTAR
EQIDDRIRGLREGADDYLGKPFSFLELVARLQALTRRSGGHEPIQITIADLWIDLISRKATRAGLRLDLTAKEFSLLSVL
ARRQGDILSKTSIAEMVWDINFDSDTNVVEVAIKRLRAKLDGPHEHKLLHTIRGMGYVLENRSAG
>Mature_225_residues
MRVLIIEDEEKTADYLRRGLTEQGYAVDVARDGIEGLHLALENDHAIVILDVMLPGLDGFGVLRALRARKQTPVIMLTAR
EQIDDRIRGLREGADDYLGKPFSFLELVARLQALTRRSGGHEPIQITIADLWIDLISRKATRAGLRLDLTAKEFSLLSVL
ARRQGDILSKTSIAEMVWDINFDSDTNVVEVAIKRLRAKLDGPHEHKLLHTIRGMGYVLENRSAG

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=52.4663677130045, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=52.9680365296804, Blast_Score=236, Evalue=8e-64,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=33.1838565022422, Blast_Score=126, Evalue=9e-31,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=34.5132743362832, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.8947368421053, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=36.5638766519824, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.9369369369369, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=33.7837837837838, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.2775330396476, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=36.697247706422, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=33.1858407079646, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=30.6666666666667, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=28.2608695652174, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=27.2058823529412, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=34.7826086956522, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25229; Mature: 25229

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIIEDEEKTADYLRRGLTEQGYAVDVARDGIEGLHLALENDHAIVILDVMLPGLDGF
CEEEEEECCHHHHHHHHHCCCCCCCEEEHHHCCCCCEEEEEECCCEEEEEEEECCCCCHH
GVLRALRARKQTPVIMLTAREQIDDRIRGLREGADDYLGKPFSFLELVARLQALTRRSGG
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCC
HEPIQITIADLWIDLISRKATRAGLRLDLTAKEFSLLSVLARRQGDILSKTSIAEMVWDI
CCCEEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEC
NFDSDTNVVEVAIKRLRAKLDGPHEHKLLHTIRGMGYVLENRSAG
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MRVLIIEDEEKTADYLRRGLTEQGYAVDVARDGIEGLHLALENDHAIVILDVMLPGLDGF
CEEEEEECCHHHHHHHHHCCCCCCCEEEHHHCCCCCEEEEEECCCEEEEEEEECCCCCHH
GVLRALRARKQTPVIMLTAREQIDDRIRGLREGADDYLGKPFSFLELVARLQALTRRSGG
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCC
HEPIQITIADLWIDLISRKATRAGLRLDLTAKEFSLLSVLARRQGDILSKTSIAEMVWDI
CCCEEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEC
NFDSDTNVVEVAIKRLRAKLDGPHEHKLLHTIRGMGYVLENRSAG
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]