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The map label for this gene is envZ [H]

Identifier: 66044363

GI number: 66044363

Start: 1259672

End: 1261123

Strand: Direct

Name: envZ [H]

Synonym: Psyr_1112

Alternate gene names: 66044363

Gene position: 1259672-1261123 (Clockwise)

Preceding gene: 66044362

Following gene: 66044364

Centisome position: 20.67

GC content: 62.19

Gene sequence:

>1452_bases
GTGAAGAGAACCGGCCTGCCGCTGCCGCGCTCGTTGTTGGGCCGCATGTTGCTGCTGACCTTGCTGGCGGTTTCGCTGGC
TCAGGCGCTGTCCAGCGTGATCTGGCTGTCACAGCTACGTGCCACGCAGATGGAGGGCCTGGTAACCAGTGCGCGCAGTC
TGGCGTACTCGATGGCGGCCAGTGTCAGCTACTTTCGCTCATTGCCGCTGGCTTACCGGCCGATGGTGCTCGACCAGTTA
CGCAGTATGGGCGGCACACGCTTCGTGGTGTCACTCAACGATCATCCGCTGGACATGCAGATCATGCAGCCCACTCCTCG
CAAGCAGGCGGTGCTGGACGTGGTGGGCGAAGTGCTGCGCCAGCGTCTGGGCAATGGTCCGGACATCACCGTATGGTTTG
CGCGGCCCGAAGATCTGAGGATCTTCAACAGCGGCCTGAAGCTCGACGAGTTGCCGCGTTCCTGGGCCCATTACGCGCTG
ACGCTTGAGCCGGTGAACCCGCCGGTGCTGGTCACGCAAATCGAAATGGCGCCCGGTGAGTGGTTCTACATCGCCTCGCT
ACTGCCTGAACCCTACACCTCGCTGGAGGAGCAGGAACTACCCCTTCAGCAGGTGTCGTTCATTGTCCTGACCAGCGCAT
TTCTGCTGTTGTTCATCGGGTTGCTGGTGCATTGGCAGAGCCGTCCGCTCAAGCGCCTGGCGCGGGCCGCACGGGACATG
TCGCTGGGCGCGGATGTCGAGCCTGTGGTCGAGGGCGGCGGCAGCGAAGTCATCGAGGTCAGCCGGGCATTCAACGCCAT
GCGCACGCGGATCAGCCGCTACCTGACCGAGCGGGGGCAGTTGTTCAGTGCCATCTCCCATGATCTGCGTACGCCCATCA
CGCGTTTGCGCCTGCGGGTCGAGTTGCTCGAGGATGAGCAACTGCAACGCAAATTCAGTCGCGACCTGGACGAGCTGGAG
CTGCTGGTCAAAGGCGCGCTGCAGTGCGTCAAGGACACCGATATTCATGAAAATATCGAGCCGGTGGACCTCAACGCGCT
GCTTGAATGTCTGGTCGAGCCCTGGCTGCTCGCTGATGGCAATGGACGTGTCACGCAGCAGGGTGAGGCACAGGCTGCCT
ATTCAGGCAAACCGCTGGCGCTCAAGCGCTGCATTGGCAACCTGATCGACAACGCGCTCAAATACGGTGACCGCGCGCAC
CTGAAGGTCGAAGACGATGCCCGCGCGTTCGTGCTGCATGTCGACGACGAAGGCCCTGGCGTTCCCGAGCAGCGCCTTGA
GCATGTTTTCGAACCGCATTTCCGCCTGGCAGGCAATCAGCAGCAGGGCTACGGCCTTGGCCTGGGCATCGCTCGCAACA
TTGCCCACAGTCATGGCGGCGAAGTCAGCCTGCAGAACCTGCGTGACGGAGGGTTGCGGGTAACGTTGTACCTGCCGAGA
ACTGCGGAATGA

Upstream 100 bases:

>100_bases
TCGCCGCGTCTGATCCGTACCATTCGTGGCAGTGGTTACCTGCTGGCCGCAAACGTCAACTCGCAAGCGGGCAACGGCTA
TTAAACCGACAGCGGCAGGC

Downstream 100 bases:

>100_bases
CTGGTTGGGAAGTGGCTTTTGGCTAGTGGTTGCAATCGGATTTAAATTGTCACCATCCTGTGACAATTGCGCGTCCCTTC
GTTACTGTCGGCGCGTCAGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKRTGLPLPRSLLGRMLLLTLLAVSLAQALSSVIWLSQLRATQMEGLVTSARSLAYSMAASVSYFRSLPLAYRPMVLDQL
RSMGGTRFVVSLNDHPLDMQIMQPTPRKQAVLDVVGEVLRQRLGNGPDITVWFARPEDLRIFNSGLKLDELPRSWAHYAL
TLEPVNPPVLVTQIEMAPGEWFYIASLLPEPYTSLEEQELPLQQVSFIVLTSAFLLLFIGLLVHWQSRPLKRLARAARDM
SLGADVEPVVEGGGSEVIEVSRAFNAMRTRISRYLTERGQLFSAISHDLRTPITRLRLRVELLEDEQLQRKFSRDLDELE
LLVKGALQCVKDTDIHENIEPVDLNALLECLVEPWLLADGNGRVTQQGEAQAAYSGKPLALKRCIGNLIDNALKYGDRAH
LKVEDDARAFVLHVDDEGPGVPEQRLEHVFEPHFRLAGNQQQGYGLGLGIARNIAHSHGGEVSLQNLRDGGLRVTLYLPR
TAE

Sequences:

>Translated_483_residues
MKRTGLPLPRSLLGRMLLLTLLAVSLAQALSSVIWLSQLRATQMEGLVTSARSLAYSMAASVSYFRSLPLAYRPMVLDQL
RSMGGTRFVVSLNDHPLDMQIMQPTPRKQAVLDVVGEVLRQRLGNGPDITVWFARPEDLRIFNSGLKLDELPRSWAHYAL
TLEPVNPPVLVTQIEMAPGEWFYIASLLPEPYTSLEEQELPLQQVSFIVLTSAFLLLFIGLLVHWQSRPLKRLARAARDM
SLGADVEPVVEGGGSEVIEVSRAFNAMRTRISRYLTERGQLFSAISHDLRTPITRLRLRVELLEDEQLQRKFSRDLDELE
LLVKGALQCVKDTDIHENIEPVDLNALLECLVEPWLLADGNGRVTQQGEAQAAYSGKPLALKRCIGNLIDNALKYGDRAH
LKVEDDARAFVLHVDDEGPGVPEQRLEHVFEPHFRLAGNQQQGYGLGLGIARNIAHSHGGEVSLQNLRDGGLRVTLYLPR
TAE
>Mature_483_residues
MKRTGLPLPRSLLGRMLLLTLLAVSLAQALSSVIWLSQLRATQMEGLVTSARSLAYSMAASVSYFRSLPLAYRPMVLDQL
RSMGGTRFVVSLNDHPLDMQIMQPTPRKQAVLDVVGEVLRQRLGNGPDITVWFARPEDLRIFNSGLKLDELPRSWAHYAL
TLEPVNPPVLVTQIEMAPGEWFYIASLLPEPYTSLEEQELPLQQVSFIVLTSAFLLLFIGLLVHWQSRPLKRLARAARDM
SLGADVEPVVEGGGSEVIEVSRAFNAMRTRISRYLTERGQLFSAISHDLRTPITRLRLRVELLEDEQLQRKFSRDLDELE
LLVKGALQCVKDTDIHENIEPVDLNALLECLVEPWLLADGNGRVTQQGEAQAAYSGKPLALKRCIGNLIDNALKYGDRAH
LKVEDDARAFVLHVDDEGPGVPEQRLEHVFEPHFRLAGNQQQGYGLGLGIARNIAHSHGGEVSLQNLRDGGLRVTLYLPR
TAE

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=329, Percent_Identity=32.2188449848024, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787894, Length=313, Percent_Identity=30.0319488817891, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=31.7343173431734, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=27.7397260273973, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=25.9927797833935, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786783, Length=293, Percent_Identity=27.6450511945392, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=25.2, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=326, Percent_Identity=23.3128834355828, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=263, Percent_Identity=26.9961977186312, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=259, Percent_Identity=24.7104247104247, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789403, Length=273, Percent_Identity=26.3736263736264, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53961; Mature: 53961

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTGLPLPRSLLGRMLLLTLLAVSLAQALSSVIWLSQLRATQMEGLVTSARSLAYSMAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVSYFRSLPLAYRPMVLDQLRSMGGTRFVVSLNDHPLDMQIMQPTPRKQAVLDVVGEVLR
HHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHH
QRLGNGPDITVWFARPEDLRIFNSGLKLDELPRSWAHYALTLEPVNPPVLVTQIEMAPGE
HHCCCCCCEEEEEECCCCCHHHHCCCCHHHCCHHHHCEEEEEECCCCCEEEEEEEECCCC
WFYIASLLPEPYTSLEEQELPLQQVSFIVLTSAFLLLFIGLLVHWQSRPLKRLARAARDM
EEEEEHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
SLGADVEPVVEGGGSEVIEVSRAFNAMRTRISRYLTERGQLFSAISHDLRTPITRLRLRV
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ELLEDEQLQRKFSRDLDELELLVKGALQCVKDTDIHENIEPVDLNALLECLVEPWLLADG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEECC
NGRVTQQGEAQAAYSGKPLALKRCIGNLIDNALKYGDRAHLKVEDDARAFVLHVDDEGPG
CCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCC
VPEQRLEHVFEPHFRLAGNQQQGYGLGLGIARNIAHSHGGEVSLQNLRDGGLRVTLYLPR
CCHHHHHHHHCCCCEECCCCCCCCEECHHHHHHHHHCCCCCEEECCCCCCCEEEEEECCC
TAE
CCC
>Mature Secondary Structure
MKRTGLPLPRSLLGRMLLLTLLAVSLAQALSSVIWLSQLRATQMEGLVTSARSLAYSMAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVSYFRSLPLAYRPMVLDQLRSMGGTRFVVSLNDHPLDMQIMQPTPRKQAVLDVVGEVLR
HHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHH
QRLGNGPDITVWFARPEDLRIFNSGLKLDELPRSWAHYALTLEPVNPPVLVTQIEMAPGE
HHCCCCCCEEEEEECCCCCHHHHCCCCHHHCCHHHHCEEEEEECCCCCEEEEEEEECCCC
WFYIASLLPEPYTSLEEQELPLQQVSFIVLTSAFLLLFIGLLVHWQSRPLKRLARAARDM
EEEEEHHCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
SLGADVEPVVEGGGSEVIEVSRAFNAMRTRISRYLTERGQLFSAISHDLRTPITRLRLRV
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ELLEDEQLQRKFSRDLDELELLVKGALQCVKDTDIHENIEPVDLNALLECLVEPWLLADG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEECC
NGRVTQQGEAQAAYSGKPLALKRCIGNLIDNALKYGDRAHLKVEDDARAFVLHVDDEGPG
CCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCC
VPEQRLEHVFEPHFRLAGNQQQGYGLGLGIARNIAHSHGGEVSLQNLRDGGLRVTLYLPR
CCHHHHHHHHCCCCEECCCCCCCCEECHHHHHHHHHCCCCCEEECCCCCCCEEEEEECCC
TAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]