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The map label for this gene is moaE [H]

Identifier: 66044322

GI number: 66044322

Start: 1211777

End: 1212226

Strand: Direct

Name: moaE [H]

Synonym: Psyr_1069

Alternate gene names: 66044322

Gene position: 1211777-1212226 (Clockwise)

Preceding gene: 66044321

Following gene: 66044325

Centisome position: 19.89

GC content: 60.22

Gene sequence:

>450_bases
ATGAGCGTTCGTGTCCAGGCAGAGGCTTTCGACCCCGGCACTGAAGTCAACGCGCTGCATGCCGCGAATCTGGGCATCGG
CGCGGTGGTCAGTTTTGTTGGCTATGTTCGGGATTTCAATGAAGGGCGTGAAGTGTCCGGCATGTTTCTCGAGCACTATC
CGGGGATGACCGAGAAGGCACTGGCAAAAATCATTGCCGATGCCGAACAGCGCTGGCCGTTGCTACGCGTTGACGTACTG
CATCGGGTTGGCGCGCTGGAGCCCGGCGAGCCGATCGTGTTCGTCGGCGTTGCCAGCGCGCACCGTCAGGCGGCGTTCGA
AGCCTGTGATTTCGTCATGGATTACCTCAAGACCCGCGCGCCGTTCTGGAAGCGTGAAAACACGTCAGAAGGCACGCGCT
GGGTCGAAGGTCGTCACAGCGATCACCAGGCGGCTGATCGCTGGAAGTAA

Upstream 100 bases:

>100_bases
ACCTGATGTGTGCTCGCAACCAGGAGCTGTGCAAGCCGACCGAACCATTGGCCGATGGCGATGAAGTCGCGTTCTTTCCG
CCCGTGACCGGAGGTTGATG

Downstream 100 bases:

>100_bases
GCATCAGGCGTTGCTGCGCACCACAGCCCTGAGCAGATGAGTCGGCGGTGTCTCGCAACTGATCTTGCGGCCCAGTTTTT
CCTCGATGGCGGGCAACTGG

Product: molybdopterin biosynthesis MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSVRVQAEAFDPGTEVNALHAANLGIGAVVSFVGYVRDFNEGREVSGMFLEHYPGMTEKALAKIIADAEQRWPLLRVDVL
HRVGALEPGEPIVFVGVASAHRQAAFEACDFVMDYLKTRAPFWKRENTSEGTRWVEGRHSDHQAADRWK

Sequences:

>Translated_149_residues
MSVRVQAEAFDPGTEVNALHAANLGIGAVVSFVGYVRDFNEGREVSGMFLEHYPGMTEKALAKIIADAEQRWPLLRVDVL
HRVGALEPGEPIVFVGVASAHRQAAFEACDFVMDYLKTRAPFWKRENTSEGTRWVEGRHSDHQAADRWK
>Mature_148_residues
SVRVQAEAFDPGTEVNALHAANLGIGAVVSFVGYVRDFNEGREVSGMFLEHYPGMTEKALAKIIADAEQRWPLLRVDVLH
RVGALEPGEPIVFVGVASAHRQAAFEACDFVMDYLKTRAPFWKRENTSEGTRWVEGRHSDHQAADRWK

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=120, Percent_Identity=37.5, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1787003, Length=122, Percent_Identity=68.0327868852459, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17509279, Length=108, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356259, Length=122, Percent_Identity=35.2459016393443, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16667; Mature: 16536

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRVQAEAFDPGTEVNALHAANLGIGAVVSFVGYVRDFNEGREVSGMFLEHYPGMTEKA
CCEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHH
LAKIIADAEQRWPLLRVDVLHRVGALEPGEPIVFVGVASAHRQAAFEACDFVMDYLKTRA
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
PFWKRENTSEGTRWVEGRHSDHQAADRWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVRVQAEAFDPGTEVNALHAANLGIGAVVSFVGYVRDFNEGREVSGMFLEHYPGMTEKA
CEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHH
LAKIIADAEQRWPLLRVDVLHRVGALEPGEPIVFVGVASAHRQAAFEACDFVMDYLKTRA
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
PFWKRENTSEGTRWVEGRHSDHQAADRWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]