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The map label for this gene is upp

Identifier: 66044222

GI number: 66044222

Start: 1102981

End: 1103619

Strand: Reverse

Name: upp

Synonym: Psyr_0969

Alternate gene names: 66044222

Gene position: 1103619-1102981 (Counterclockwise)

Preceding gene: 66044226

Following gene: 66044221

Centisome position: 18.11

GC content: 61.5

Gene sequence:

>639_bases
ATGCCCATTCGTGAGATCCGTCACCCACTGATACGCCACAAGCTCGGCCTTATGCGCCGCGCCGACATCAGCACCAAGAA
TTTCCGCGAGCTGGCTCAGGAAGTCGGCGCGCTGCTGACCTATGAAGCCACCGCCGACCTGACGCTGGAAAACTACGACA
TTCAAGGCTGGGCCGGTACGGTGTCAGTCGAGAAGATCGCGGGCAAGAAAATCACTGTCGTGCCGATTCTGCGCGCCGGT
ATCGGCATGCTGGACGGCGTGCTCAGCCTGATTCCGGGCGCCAAGGTCAGCGCGGTCGGCGTGGCCCGCAACGAAGAAAC
CCTGCAGGCGCACACCTACCTGGAAAAACTGGTCCCGGAAATCGACGAGCGCCTGGCAATGATCATCGACCCGATGCTGG
CCACCGGCAGCTCGATGGTCGCCACCATCGATCTGCTGAAGAAGGCCGGCTGCAAGGAAATCCGCGCCATGGTCCTGGTC
GCGGCGCCCGAAGGCATCGCTGCCGTAGAGAAGGCGCACCCGGACGTGATGATCTACACCGCTTCCATCGATGAGCGCCT
GAACGAACACGGCTACATCATTCCGGGCCTGGGCGATGCCGGTGACAAGATTTTCGGCACCAAACAGAAGGACGCGTAA

Upstream 100 bases:

>100_bases
CGAACGTCGAAGCTTCGTAACGATACTGCATGTGCTTTAAGACAGTCAGTGCCGAATAGATTAACCTAGACCGATTTTTG
CCCCGCTGGAGCCTTTCCCC

Downstream 100 bases:

>100_bases
CCCGATGACGCAGCAGGAGTTCAACGATCCACTGTGGCGCACGATTTTATCCGGCGCGCAAATGCTCTTCGTGGCCTTTG
GCGCGCTGGTGCTGATGCCG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLENYDIQGWAGTVSVEKIAGKKITVVPILRAG
IGMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLV
AAPEGIAAVEKAHPDVMIYTASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA

Sequences:

>Translated_212_residues
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLENYDIQGWAGTVSVEKIAGKKITVVPILRAG
IGMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLV
AAPEGIAAVEKAHPDVMIYTASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA
>Mature_211_residues
PIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLENYDIQGWAGTVSVEKIAGKKITVVPILRAGI
GMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLVA
APEGIAAVEKAHPDVMIYTASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=27.7227722772277, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=27.7227722772277, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=71.6346153846154, Blast_Score=313, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.3731343283582, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.3731343283582, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=153, Percent_Identity=35.2941176470588, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550449, Length=150, Percent_Identity=28.6666666666667, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573516, Length=150, Percent_Identity=28.6666666666667, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573514, Length=150, Percent_Identity=28.6666666666667, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573512, Length=150, Percent_Identity=28.6666666666667, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_PSE14 (Q48MT3)

Other databases:

- EMBL:   CP000058
- RefSeq:   YP_273289.1
- HSSP:   Q9WZI0
- ProteinModelPortal:   Q48MT3
- SMR:   Q48MT3
- STRING:   Q48MT3
- GeneID:   3557546
- GenomeReviews:   CP000058_GR
- KEGG:   psp:PSPPH_1018
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   Q48MT3
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22935; Mature: 22804

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLENYDIQGWAGT
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCEEEECCCCCCCCCC
VSVEKIAGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPE
EEHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
IDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLVAAPEGIAAVEKAHPDVMIYT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHEEEEEECCCCHHHHHHCCCCEEEEE
ASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA
CCHHHHHCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLENYDIQGWAGT
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCEEEECCCCCCCCCC
VSVEKIAGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPE
EEHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
IDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLVAAPEGIAAVEKAHPDVMIYT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHEEEEEECCCCHHHHHHCCCCEEEEE
ASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA
CCHHHHHCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA