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The map label for this gene is uraA [H]

Identifier: 66044221

GI number: 66044221

Start: 1101699

End: 1102976

Strand: Reverse

Name: uraA [H]

Synonym: Psyr_0968

Alternate gene names: 66044221

Gene position: 1102976-1101699 (Counterclockwise)

Preceding gene: 66044222

Following gene: 66044218

Centisome position: 18.1

GC content: 61.35

Gene sequence:

>1278_bases
ATGACGCAGCAGGAGTTCAACGATCCACTGTGGCGCACGATTTTATCCGGCGCGCAAATGCTCTTCGTGGCCTTTGGCGC
GCTGGTGCTGATGCCGCTGATCACCGGGCTCGATCCGAACGTGGCGCTGTTCACCGCAGGCCTGGGCACGCTGCTGTTCC
AGATCGTCACCGGGCGTCAGGTGCCGGTCTTTCTGGCCTCGAGCTTTGCCTTCATCACCCCGATCATCCTCGCCAAGGGC
CAGTTCGGTCTGGCCGCGACCATGGGCGGCGTCATGGCGGCAGGCTTTGTGTATACCTTTCTCGGTCTGGCGGTGAAGAT
CAAGGGCACCGGTTTCATTGATCGCCTGCTGCCTCCCGTGGTGATCGGGCCGGTCATCATCTCCATCGGCCTGGCCATGG
CCCCGATTGCAGCCAACATGGCGATGGGCAAGTCCGGCGATGGCGTGCAGTTGATTCCTTATCAGACCGCCATGCTGATT
TCGATGCCCGCCTTGCTGACCACGCTGATCGTGGCGGTGTTCGGCAAAGGCATTTTCCGTCTGGTGCCGATCATCTCCGG
CGTGCTGGTGGGCTTCGCGCTGTCGTTCTACTTTGGTGTGGTCGATACCAAAAAAATCGCTGACGCCGCCTGGCTGGCCT
TGCCGCACTTCACTGCACCGGAATTCAACTGGCAGGCGATTCTGTTCATTGTTCCGGTGGCCCTGGCCCCGGCCATCGAG
CACATCGGCGGCGTGATTGCAGTCGGCAGTGTGACCGGACGCGATTACCTGAAAAAGCCGGGCCTGCACCGCACGCTGTT
CGGCGACGGCATCGCTACCACCGCTGCCGGTCTGTTCGGCGGCCCGCCCAATACCACCTACGCCGAAGTGACGGGCGCGG
TGATGCTGACCAAGAACTACAACCCGCAGATCATGATCTGGGCATCGTTCTTTGCCATCACGCTGGCGTTCATTGGCAAG
TTCGGCGCGTTGCTGCAGAGCATTCCGGTGCCGGTAATGGGCGGCATTCTGTGCCTGCTGTTCGGTTCGATTGCTGCGGT
GGGCATGAACACCCTGATCCGCCACAAGATCGACCTGGCCGAAGCGCGCAATCTGGTGATCGTCTCGGTCACCCTGGTAT
TCGGGATCGGCGGCGTATTGATCGGCACCGGCAACGGCCCGAACGATTTCGGCCTGAAGGGCATCGCCCTGTGCGCCGTG
ACCGCCATCGCCCTGAACCTGATCCTGCCGGGCAATGACAGCTGGAAGAACAAGCAACTGGATGATCAGTTGCCGTAA

Upstream 100 bases:

>100_bases
TCCATCGATGAGCGCCTGAACGAACACGGCTACATCATTCCGGGCCTGGGCGATGCCGGTGACAAGATTTTCGGCACCAA
ACAGAAGGACGCGTAACCCG

Downstream 100 bases:

>100_bases
TCCTGCCGGGAGTGGGCTTGACCATCGTGCCAACGCTCCGCGTTGGCATGCAGTTCTGGACGCTCTGCGTCCGATCCTGA
ATGTGCGGTGCAGCGCAGAT

Product: xanthine/uracil permease family protein

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTQQEFNDPLWRTILSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTLLFQIVTGRQVPVFLASSFAFITPIILAKG
QFGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPVVIGPVIISIGLAMAPIAANMAMGKSGDGVQLIPYQTAMLI
SMPALLTTLIVAVFGKGIFRLVPIISGVLVGFALSFYFGVVDTKKIADAAWLALPHFTAPEFNWQAILFIVPVALAPAIE
HIGGVIAVGSVTGRDYLKKPGLHRTLFGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNYNPQIMIWASFFAITLAFIGK
FGALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLAEARNLVIVSVTLVFGIGGVLIGTGNGPNDFGLKGIALCAV
TAIALNLILPGNDSWKNKQLDDQLP

Sequences:

>Translated_425_residues
MTQQEFNDPLWRTILSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTLLFQIVTGRQVPVFLASSFAFITPIILAKG
QFGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPVVIGPVIISIGLAMAPIAANMAMGKSGDGVQLIPYQTAMLI
SMPALLTTLIVAVFGKGIFRLVPIISGVLVGFALSFYFGVVDTKKIADAAWLALPHFTAPEFNWQAILFIVPVALAPAIE
HIGGVIAVGSVTGRDYLKKPGLHRTLFGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNYNPQIMIWASFFAITLAFIGK
FGALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLAEARNLVIVSVTLVFGIGGVLIGTGNGPNDFGLKGIALCAV
TAIALNLILPGNDSWKNKQLDDQLP
>Mature_424_residues
TQQEFNDPLWRTILSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTLLFQIVTGRQVPVFLASSFAFITPIILAKGQ
FGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPVVIGPVIISIGLAMAPIAANMAMGKSGDGVQLIPYQTAMLIS
MPALLTTLIVAVFGKGIFRLVPIISGVLVGFALSFYFGVVDTKKIADAAWLALPHFTAPEFNWQAILFIVPVALAPAIEH
IGGVIAVGSVTGRDYLKKPGLHRTLFGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNYNPQIMIWASFFAITLAFIGKF
GALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLAEARNLVIVSVTLVFGIGGVLIGTGNGPNDFGLKGIALCAVT
AIALNLILPGNDSWKNKQLDDQLP

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=438, Percent_Identity=25.3424657534247, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI44680143, Length=439, Percent_Identity=25.0569476082005, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI44680148, Length=434, Percent_Identity=25.5760368663594, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40316845, Length=434, Percent_Identity=25.5760368663594, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788843, Length=400, Percent_Identity=40, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI87081818, Length=420, Percent_Identity=38.8095238095238, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082181, Length=431, Percent_Identity=29.0023201856148, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790087, Length=245, Percent_Identity=23.6734693877551, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=175, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=420, Percent_Identity=22.3809523809524, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356175, Length=436, Percent_Identity=24.7706422018349, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44498; Mature: 44367

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQEFNDPLWRTILSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTLLFQIVTGRQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VPVFLASSFAFITPIILAKGQFGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPV
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCHH
VIGPVIISIGLAMAPIAANMAMGKSGDGVQLIPYQTAMLISMPALLTTLIVAVFGKGIFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHH
LVPIISGVLVGFALSFYFGVVDTKKIADAAWLALPHFTAPEFNWQAILFIVPVALAPAIE
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
HIGGVIAVGSVTGRDYLKKPGLHRTLFGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNY
HCCCEEEECCCCCHHHHHCCCCCEEHHCCCHHHHHHHHCCCCCCCCHHHEEEEEEEEECC
NPQIMIWASFFAITLAFIGKFGALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLA
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARNLVIVSVTLVFGIGGVLIGTGNGPNDFGLKGIALCAVTAIALNLILPGNDSWKNKQL
HCCCEEEEEHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCC
DDQLP
CCCCC
>Mature Secondary Structure 
TQQEFNDPLWRTILSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTLLFQIVTGRQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VPVFLASSFAFITPIILAKGQFGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPV
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCHH
VIGPVIISIGLAMAPIAANMAMGKSGDGVQLIPYQTAMLISMPALLTTLIVAVFGKGIFR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHH
LVPIISGVLVGFALSFYFGVVDTKKIADAAWLALPHFTAPEFNWQAILFIVPVALAPAIE
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
HIGGVIAVGSVTGRDYLKKPGLHRTLFGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNY
HCCCEEEECCCCCHHHHHCCCCCEEHHCCCHHHHHHHHCCCCCCCCHHHEEEEEEEEECC
NPQIMIWASFFAITLAFIGKFGALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLA
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARNLVIVSVTLVFGIGGVLIGTGNGPNDFGLKGIALCAVTAIALNLILPGNDSWKNKQL
HCCCEEEEEHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCC
DDQLP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]