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The map label for this gene is fabG [C]

Identifier: 66044212

GI number: 66044212

Start: 1093438

End: 1094226

Strand: Reverse

Name: fabG [C]

Synonym: Psyr_0959

Alternate gene names: 66044212

Gene position: 1094226-1093438 (Counterclockwise)

Preceding gene: 66044213

Following gene: 66044211

Centisome position: 17.96

GC content: 63.24

Gene sequence:

>789_bases
ATGAGCACTCCTGTTGCACGACGCATCTGGTTGACCGGAGCAAGCAGCGGCATTGGCCTGGCGCTGGCCAAAGAACTGCT
CAACGCCGGTCACCGGCTGGCGCTGACCGCCCGCACGCTTGAGCCATTGCAGAACCTTGCGAACGTTTATCCCACGCAAG
TGCTGCTGGTGACCGGTGACATCACCGACCCCGAGCAAGTCAAGGCGATTGCCGACGACATCGCCCGGCAATGGGGAGCC
CTGGACACGGCCATCTTCAACGCCGGCACCTGCGAATACATCGACGCCCGACAGTTTGAAGCGGCCATGGTCGAACGCGT
GGTACGCACCAACCTGCTGGCCAGCAGTTACTGCATCGAGCACGCGTTGCCGCTGCTGCGCAAAGGTCATCAGCCGCATC
TGGTCGGCGTGGCCAGTGCGGTGACCTACCTGGCCCTGCCCCGCGCCGAAGCCTACGGCGCGTCGAAAGCCGGCCTGCGT
TATCTGCTCGAAGCGCTGCGGCTGGACCTGGCCAGCGAAAACATCGACGTGACAGTGGTCAGCCCCGGGTTCGTCGACAC
ACCGCTGACGCAGAAAAATGATTTCCCCATGCCCATGCGCTGGCCTGTCGAGAGGGCAGCCAAACATATCGCCAGCAAAC
TGGGGCGCAACAAACGCCCACTGGATATCGCCTTTCCGGCGCTGTTCATCTTCAGCATGAGCTTGCTGGCCCTGCTCCCG
GCACGCGCCCGGCTGGCCCTCGGCAAACGCATGGCGCGCAGCGAATCGTCGAATAAGGACGCGCAATGA

Upstream 100 bases:

>100_bases
AGGTTTATCGACACCGGGACTATTTCGATGCCGGTGCATTGCTCTACGAACATCTGCCCATCATGGGTCGAGTCATCCAT
TGGTTGAAGAAGAGGTTGGG

Downstream 100 bases:

>100_bases
AGATCGCAGTCATTGGCAGCGGGATTTCTGGCCTGACCAGTGCCTACCTGCTCAACCGCGCGCATGAGGTGACCGTGTTC
GAGTCTTCGGACTGGATCGG

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSTPVARRIWLTGASSGIGLALAKELLNAGHRLALTARTLEPLQNLANVYPTQVLLVTGDITDPEQVKAIADDIARQWGA
LDTAIFNAGTCEYIDARQFEAAMVERVVRTNLLASSYCIEHALPLLRKGHQPHLVGVASAVTYLALPRAEAYGASKAGLR
YLLEALRLDLASENIDVTVVSPGFVDTPLTQKNDFPMPMRWPVERAAKHIASKLGRNKRPLDIAFPALFIFSMSLLALLP
ARARLALGKRMARSESSNKDAQ

Sequences:

>Translated_262_residues
MSTPVARRIWLTGASSGIGLALAKELLNAGHRLALTARTLEPLQNLANVYPTQVLLVTGDITDPEQVKAIADDIARQWGA
LDTAIFNAGTCEYIDARQFEAAMVERVVRTNLLASSYCIEHALPLLRKGHQPHLVGVASAVTYLALPRAEAYGASKAGLR
YLLEALRLDLASENIDVTVVSPGFVDTPLTQKNDFPMPMRWPVERAAKHIASKLGRNKRPLDIAFPALFIFSMSLLALLP
ARARLALGKRMARSESSNKDAQ
>Mature_261_residues
STPVARRIWLTGASSGIGLALAKELLNAGHRLALTARTLEPLQNLANVYPTQVLLVTGDITDPEQVKAIADDIARQWGAL
DTAIFNAGTCEYIDARQFEAAMVERVVRTNLLASSYCIEHALPLLRKGHQPHLVGVASAVTYLALPRAEAYGASKAGLRY
LLEALRLDLASENIDVTVVSPGFVDTPLTQKNDFPMPMRWPVERAAKHIASKLGRNKRPLDIAFPALFIFSMSLLALLPA
RARLALGKRMARSESSNKDAQ

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=264, Percent_Identity=28.7878787878788, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI59889578, Length=242, Percent_Identity=26.4462809917355, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7706318, Length=193, Percent_Identity=26.9430051813472, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=26.6094420600858, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254992, Length=220, Percent_Identity=28.1818181818182, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI226371731, Length=225, Percent_Identity=25.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI19923817, Length=196, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=183, Percent_Identity=27.3224043715847, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789208, Length=227, Percent_Identity=24.6696035242291, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786701, Length=185, Percent_Identity=28.1081081081081, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787820, Length=176, Percent_Identity=24.4318181818182, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786812, Length=232, Percent_Identity=26.2931034482759, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367365, Length=203, Percent_Identity=27.5862068965517, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=252, Percent_Identity=25.7936507936508, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=193, Percent_Identity=29.0155440414508, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322227, Length=196, Percent_Identity=27.5510204081633, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322226, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644339, Length=188, Percent_Identity=32.9787234042553, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116007236, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358495, Length=194, Percent_Identity=27.319587628866, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24663911, Length=213, Percent_Identity=28.169014084507, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641232, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=189, Percent_Identity=31.2169312169312, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580925, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI116007238, Length=172, Percent_Identity=26.7441860465116, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=185, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24584744, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28574402, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28571526, Length=198, Percent_Identity=29.2929292929293, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28533; Mature: 28402

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPVARRIWLTGASSGIGLALAKELLNAGHRLALTARTLEPLQNLANVYPTQVLLVTGD
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEECC
ITDPEQVKAIADDIARQWGALDTAIFNAGTCEYIDARQFEAAMVERVVRTNLLASSYCIE
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HALPLLRKGHQPHLVGVASAVTYLALPRAEAYGASKAGLRYLLEALRLDLASENIDVTVV
HHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
SPGFVDTPLTQKNDFPMPMRWPVERAAKHIASKLGRNKRPLDIAFPALFIFSMSLLALLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ARARLALGKRMARSESSNKDAQ
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STPVARRIWLTGASSGIGLALAKELLNAGHRLALTARTLEPLQNLANVYPTQVLLVTGD
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCEEEEEECC
ITDPEQVKAIADDIARQWGALDTAIFNAGTCEYIDARQFEAAMVERVVRTNLLASSYCIE
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HALPLLRKGHQPHLVGVASAVTYLALPRAEAYGASKAGLRYLLEALRLDLASENIDVTVV
HHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
SPGFVDTPLTQKNDFPMPMRWPVERAAKHIASKLGRNKRPLDIAFPALFIFSMSLLALLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ARARLALGKRMARSESSNKDAQ
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730672 [H]