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The map label for this gene is rmlA1 [H]

Identifier: 66044179

GI number: 66044179

Start: 1051663

End: 1052544

Strand: Reverse

Name: rmlA1 [H]

Synonym: Psyr_0924

Alternate gene names: 66044179

Gene position: 1052544-1051663 (Counterclockwise)

Preceding gene: 66044180

Following gene: 66044171

Centisome position: 17.27

GC content: 59.3

Gene sequence:

>882_bases
ATGGCTCGTAAAGGAATTATTCTCGCCGGCGGCTCGGGTACCCGTTTGCATCCGGCCACGCTCTCTGTCTCCAAACAGTT
GTTGCCGGTGTACGACAAGCCGATGATCTACTACCCGCTGTGCACGCTGTTATTGGCCGGGATCCGTGACATTCTGATCA
TCTCCACGCCGCAGGACACGCCGCGCTTCTCGCAGTTGCTGGGCGACGGCAGCCAGTGGGGACTGAGCCTGACCTACGCC
GTTCAGCCAAGTCCGGACGGGCTGGCTCAGGCGTTCACCATCGGCGCAGACTTCATCGGCAACGATGCATCGGCGCTGGT
ACTGGGCGACAACATTTTCTACGGCCATGACTTCCAGTCGCTGCTGCTCAATGCCAGCAACCGTGAGTCGGGTGCCTCGG
TCTTCGCGTATCACGTGCAGGACCCCGAGCGTTATGGCGTAGCCGAATTCGATGACAGTGGCCGAGTGCTGTCGCTGGAA
GAGAAGCCCAAGGTTGCCAAGTCGAATTACGCCGTCACCGGCTTGTACTTCTACGACAATCAGGTGGTCGATCTGGCCCG
CCAGTTGAAGCCCTCCCCACGCGGCGAGCTGGAGATCACCGATCTCAACACGCTGTACCTGGAGCAGAAACAGCTGCACG
TAGAGATCATGGGCCGTGGCTATGCCTGGCTGGACACCGGCACGCATGACAGCCTGCTGGAAGCCGGCCAGTACATCGCC
ACGCTGGAAAGGCGCCAGGGCTTGAAGGTCGCCTGCCCGGAAGAGATCTGCTATCGCGCGGGCTGGATTGATGGTGCGCA
GCTTGAAAAGCTTGCACAGCCGTTGATCAAGAATGGCTACGGCCAGTATTTGAAGAACGTGCTGAAGGAAAAGGTTTTCT
GA

Upstream 100 bases:

>100_bases
TGGCTTTGAGTAAACTCGAAACTGCTTTTCAATTGAAGATGCCGTCTTGGCAACAAGGCGCACAACGCATGCTGGACGAA
ATCCAGCGCTAAGGACTCTC

Downstream 100 bases:

>100_bases
CCTGAATTTGACGGTTCGAGATGCCAGATCGATAAAGGGCGCGATACCGTTTTTAACGGTATCGCGCCCTTTCGCTGTTT
AGCGCTGCTGACAGGAGTTA

Product: glucose-1-phosphate thymidylyltransferase, long form

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MARKGIILAGGSGTRLHPATLSVSKQLLPVYDKPMIYYPLCTLLLAGIRDILIISTPQDTPRFSQLLGDGSQWGLSLTYA
VQPSPDGLAQAFTIGADFIGNDASALVLGDNIFYGHDFQSLLLNASNRESGASVFAYHVQDPERYGVAEFDDSGRVLSLE
EKPKVAKSNYAVTGLYFYDNQVVDLARQLKPSPRGELEITDLNTLYLEQKQLHVEIMGRGYAWLDTGTHDSLLEAGQYIA
TLERRQGLKVACPEEICYRAGWIDGAQLEKLAQPLIKNGYGQYLKNVLKEKVF

Sequences:

>Translated_293_residues
MARKGIILAGGSGTRLHPATLSVSKQLLPVYDKPMIYYPLCTLLLAGIRDILIISTPQDTPRFSQLLGDGSQWGLSLTYA
VQPSPDGLAQAFTIGADFIGNDASALVLGDNIFYGHDFQSLLLNASNRESGASVFAYHVQDPERYGVAEFDDSGRVLSLE
EKPKVAKSNYAVTGLYFYDNQVVDLARQLKPSPRGELEITDLNTLYLEQKQLHVEIMGRGYAWLDTGTHDSLLEAGQYIA
TLERRQGLKVACPEEICYRAGWIDGAQLEKLAQPLIKNGYGQYLKNVLKEKVF
>Mature_292_residues
ARKGIILAGGSGTRLHPATLSVSKQLLPVYDKPMIYYPLCTLLLAGIRDILIISTPQDTPRFSQLLGDGSQWGLSLTYAV
QPSPDGLAQAFTIGADFIGNDASALVLGDNIFYGHDFQSLLLNASNRESGASVFAYHVQDPERYGVAEFDDSGRVLSLEE
KPKVAKSNYAVTGLYFYDNQVVDLARQLKPSPRGELEITDLNTLYLEQKQLHVEIMGRGYAWLDTGTHDSLLEAGQYIAT
LERRQGLKVACPEEICYRAGWIDGAQLEKLAQPLIKNGYGQYLKNVLKEKVF

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=263, Percent_Identity=25.0950570342205, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI11761619, Length=263, Percent_Identity=25.0950570342205, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=74.6527777777778, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=63.1944444444444, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931050, Length=190, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=261, Percent_Identity=29.8850574712644, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=24.8995983935743, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=24.8995983935743, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32350; Mature: 32219

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKGIILAGGSGTRLHPATLSVSKQLLPVYDKPMIYYPLCTLLLAGIRDILIISTPQDT
CCCCCEEEECCCCCEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCC
PRFSQLLGDGSQWGLSLTYAVQPSPDGLAQAFTIGADFIGNDASALVLGDNIFYGHDFQS
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEECHHHCCCCCCEEEEECCEEECCCHHH
LLLNASNRESGASVFAYHVQDPERYGVAEFDDSGRVLSLEEKPKVAKSNYAVTGLYFYDN
HHCCCCCCCCCCEEEEEEECCCHHCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEECC
QVVDLARQLKPSPRGELEITDLNTLYLEQKQLHVEIMGRGYAWLDTGTHDSLLEAGQYIA
HHHHHHHHCCCCCCCCEEEEECCEEEEECCEEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLERRQGLKVACPEEICYRAGWIDGAQLEKLAQPLIKNGYGQYLKNVLKEKVF
HHHHHCCCEEECHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARKGIILAGGSGTRLHPATLSVSKQLLPVYDKPMIYYPLCTLLLAGIRDILIISTPQDT
CCCCEEEECCCCCEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCC
PRFSQLLGDGSQWGLSLTYAVQPSPDGLAQAFTIGADFIGNDASALVLGDNIFYGHDFQS
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEECHHHCCCCCCEEEEECCEEECCCHHH
LLLNASNRESGASVFAYHVQDPERYGVAEFDDSGRVLSLEEKPKVAKSNYAVTGLYFYDN
HHCCCCCCCCCCEEEEEEECCCHHCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEECC
QVVDLARQLKPSPRGELEITDLNTLYLEQKQLHVEIMGRGYAWLDTGTHDSLLEAGQYIA
HHHHHHHHCCCCCCCCEEEEECCEEEEECCEEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLERRQGLKVACPEEICYRAGWIDGAQLEKLAQPLIKNGYGQYLKNVLKEKVF
HHHHHCCCEEECHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]