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The map label for this gene is tlpA [H]

Identifier: 66044160

GI number: 66044160

Start: 1024669

End: 1026591

Strand: Reverse

Name: tlpA [H]

Synonym: Psyr_0905

Alternate gene names: 66044160

Gene position: 1026591-1024669 (Counterclockwise)

Preceding gene: 66044162

Following gene: 66044158

Centisome position: 16.85

GC content: 59.75

Gene sequence:

>1923_bases
ATGAGTAGCTGGTTTGCAAACATCAGCGTGAATATGAAACTGGCCCTCGGCTTCGGTCTGGTACTTGTTTTTACAGCCAT
TCTTGCACTGACTGGCTGGACCAGCATGAGCGGGCTGATCAACCGCAGTAACTGGATGAGTGACATTACTTCACTCAATG
CGCAATTGACCAAACTGCGCGTGACGCGCCTGCAATACATGGTGGCCGACGGCGACGAGAAGGTAGCCGAAACCGTGCAG
ACCTCGCTGGATAGCTTCAAGGCGTATCAGGAAAAACTGCGGGCCTCGTTCAAAAGTCCCGAAAACCTGAAAATGCTCGA
TCAGTTGGGCATCGTGATCGCTGACTACCAGAAGTCCCTCAACAACATGCGCAGTGGCTACAAGGCCAGCACCGCTGCGC
GTGATGAGCTGACGACCCACGCGGTCAAAAGCCTCGCGGTGTTCGAGCAGCTTGTGACTGAAGTCAGAAACATGGACCCG
GCTGACGCCAACCGGTTCGAGCAGTACCGACTCGTCACCGATGCCAAAGATGACTTGAGACTCGCACGCTATGAAGTGCG
CGGCTACACCACCAATGCCACGCCCGAGACCGAGCAGGCAGCTGTTTCGAAACTGGATTCGGCCATCAAGGATCTGGACG
CGCTCAAGACGACCTTCAGCGGCACTCAGGCCGACCAGCTCAGGCAGCTGGAAACCTCGTTGATGGCTTACCGGACGACC
TTGCAAAACTTCAAGGCCGCCACGGGCACGATTGTCCAGGCGCGCAAGGAAATGACCACGCAAGGGCAGGATATCGTCAA
GATCAGCGAGGACATGTACAAGCTGCAACTGGATCGCCGCGATCAGGAAAGCGCACAGGCGCGTACCACGCAGATCACCT
GCACCCTGTTGGCTATCATTCTGGGCATTATCGCCGCAGTGATCATCACCCGGCAGATTACCCGTCCCCTGCGCGAAACC
CTGGCAGTGGTCGACCGTATTGCGTCCGGTGACCTGACCCAGACCCTCGCGGTGACACGCAGTGATGAGCTCGGCGTTCT
GCAGCAAGGCATCCAGCGCATGGGCACCACTTTGCGCGAACTGATTGGCGGTATTCGCGACAGCGTCGTACAGATCGCCA
GTGCCGCCGAAGAGCTGTCGGCGGTTACCGAACAGACCAGCGCTGGCGTCAACAGCCAGAAAGTCGAAACCGATCAGGTC
GCCACCGCCATGCACGAGATGTCGGCGACGGTTGCAGAAGTGGCGCGTAACGCCGAACAGGCCTCGCAGGCCGCGTCCAA
CGCCGACCGCGAAGCGCGTGACGGTGACAAGGTGGTGGGTGAAGCGATCGCCCAGATCGAGCGTCTGGCCAATGAAGTGG
GCCGCTCGGTTGATGCCATGACTGAGCTGGAGCAGGAAAGCGACAAGATCGGCAAGGTCATGGACGTCATCAAGGCGGTG
GCCGAACAGACCAACCTGCTGGCGCTCAACGCCGCCATCGAAGCGGCTCGTGCGGGTGAAGCCGGACGTGGTTTTGCCGT
GGTTGCCGACGAAGTTCGCGGCCTGGCACAACGTACGCAGCAGTCCACCGTGGAGATCGAAACACTGGTCGCTGCGCTGC
AAAGCGGTACGCGCCAAGTGTCCAGCATCATGCTCAACAGCCGCGAACTGACCGTCAGCAGCGTGACCCTCAGCCGTCAG
GCAGGTACGTCGCTGGGCAGCATCACGCAAACGGTCTCCAGCATTCAGGCGATGAACCAGCAGATTGCCGCCGCCGCTGA
AGAGCAAAGCGCGGTCGCTGAGGAAATCAGCCGCAGCATCGTCAATGTCCGCGATGTGTCCGAGCAGACTGCTTCGGCCA
GCGAAGAAACCGCTGCGTCCAGCGTCGAACTGGCACGCCTGGGCGGGCAACTGCAGACGATGGTCAGCCGCTTCCGCATC
TGA

Upstream 100 bases:

>100_bases
AGTTCCTGCCGATAGTGTCTGTATACCTCACCCCGCCCTGACCTGTATGCCATACCTTTCAGGGATAAGACCGTTTCAAT
GGCAGTTGTTGGAGAATTCA

Downstream 100 bases:

>100_bases
TCACCCAGCGTTGACATCAAGCCCGGTCTTTACCGGGCTTGATTGTTTCTGCACCCGTGACAATCAGGCCTGCGGCGGCT
GCCCGTTGGACGCCGACAGG

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSSWFANISVNMKLALGFGLVLVFTAILALTGWTSMSGLINRSNWMSDITSLNAQLTKLRVTRLQYMVADGDEKVAETVQ
TSLDSFKAYQEKLRASFKSPENLKMLDQLGIVIADYQKSLNNMRSGYKASTAARDELTTHAVKSLAVFEQLVTEVRNMDP
ADANRFEQYRLVTDAKDDLRLARYEVRGYTTNATPETEQAAVSKLDSAIKDLDALKTTFSGTQADQLRQLETSLMAYRTT
LQNFKAATGTIVQARKEMTTQGQDIVKISEDMYKLQLDRRDQESAQARTTQITCTLLAIILGIIAAVIITRQITRPLRET
LAVVDRIASGDLTQTLAVTRSDELGVLQQGIQRMGTTLRELIGGIRDSVVQIASAAEELSAVTEQTSAGVNSQKVETDQV
ATAMHEMSATVAEVARNAEQASQAASNADREARDGDKVVGEAIAQIERLANEVGRSVDAMTELEQESDKIGKVMDVIKAV
AEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQQSTVEIETLVAALQSGTRQVSSIMLNSRELTVSSVTLSRQ
AGTSLGSITQTVSSIQAMNQQIAAAAEEQSAVAEEISRSIVNVRDVSEQTASASEETAASSVELARLGGQLQTMVSRFRI

Sequences:

>Translated_640_residues
MSSWFANISVNMKLALGFGLVLVFTAILALTGWTSMSGLINRSNWMSDITSLNAQLTKLRVTRLQYMVADGDEKVAETVQ
TSLDSFKAYQEKLRASFKSPENLKMLDQLGIVIADYQKSLNNMRSGYKASTAARDELTTHAVKSLAVFEQLVTEVRNMDP
ADANRFEQYRLVTDAKDDLRLARYEVRGYTTNATPETEQAAVSKLDSAIKDLDALKTTFSGTQADQLRQLETSLMAYRTT
LQNFKAATGTIVQARKEMTTQGQDIVKISEDMYKLQLDRRDQESAQARTTQITCTLLAIILGIIAAVIITRQITRPLRET
LAVVDRIASGDLTQTLAVTRSDELGVLQQGIQRMGTTLRELIGGIRDSVVQIASAAEELSAVTEQTSAGVNSQKVETDQV
ATAMHEMSATVAEVARNAEQASQAASNADREARDGDKVVGEAIAQIERLANEVGRSVDAMTELEQESDKIGKVMDVIKAV
AEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQQSTVEIETLVAALQSGTRQVSSIMLNSRELTVSSVTLSRQ
AGTSLGSITQTVSSIQAMNQQIAAAAEEQSAVAEEISRSIVNVRDVSEQTASASEETAASSVELARLGGQLQTMVSRFRI
>Mature_639_residues
SSWFANISVNMKLALGFGLVLVFTAILALTGWTSMSGLINRSNWMSDITSLNAQLTKLRVTRLQYMVADGDEKVAETVQT
SLDSFKAYQEKLRASFKSPENLKMLDQLGIVIADYQKSLNNMRSGYKASTAARDELTTHAVKSLAVFEQLVTEVRNMDPA
DANRFEQYRLVTDAKDDLRLARYEVRGYTTNATPETEQAAVSKLDSAIKDLDALKTTFSGTQADQLRQLETSLMAYRTTL
QNFKAATGTIVQARKEMTTQGQDIVKISEDMYKLQLDRRDQESAQARTTQITCTLLAIILGIIAAVIITRQITRPLRETL
AVVDRIASGDLTQTLAVTRSDELGVLQQGIQRMGTTLRELIGGIRDSVVQIASAAEELSAVTEQTSAGVNSQKVETDQVA
TAMHEMSATVAEVARNAEQASQAASNADREARDGDKVVGEAIAQIERLANEVGRSVDAMTELEQESDKIGKVMDVIKAVA
EQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQQSTVEIETLVAALQSGTRQVSSIMLNSRELTVSSVTLSRQA
GTSLGSITQTVSSIQAMNQQIAAAAEEQSAVAEEISRSIVNVRDVSEQTASASEETAASSVELARLGGQLQTMVSRFRI

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=349, Percent_Identity=34.9570200573066, Blast_Score=169, Evalue=6e-43,
Organism=Escherichia coli, GI2367378, Length=393, Percent_Identity=31.8066157760814, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1788194, Length=396, Percent_Identity=31.5656565656566, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788195, Length=336, Percent_Identity=33.6309523809524, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1789453, Length=351, Percent_Identity=27.3504273504274, Blast_Score=119, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 69355; Mature: 69224

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSWFANISVNMKLALGFGLVLVFTAILALTGWTSMSGLINRSNWMSDITSLNAQLTKLR
CCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTRLQYMVADGDEKVAETVQTSLDSFKAYQEKLRASFKSPENLKMLDQLGIVIADYQKSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHH
NNMRSGYKASTAARDELTTHAVKSLAVFEQLVTEVRNMDPADANRFEQYRLVTDAKDDLR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHH
LARYEVRGYTTNATPETEQAAVSKLDSAIKDLDALKTTFSGTQADQLRQLETSLMAYRTT
HHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LQNFKAATGTIVQARKEMTTQGQDIVKISEDMYKLQLDRRDQESAQARTTQITCTLLAII
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LGIIAAVIITRQITRPLRETLAVVDRIASGDLTQTLAVTRSDELGVLQQGIQRMGTTLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LIGGIRDSVVQIASAAEELSAVTEQTSAGVNSQKVETDQVATAMHEMSATVAEVARNAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASQAASNADREARDGDKVVGEAIAQIERLANEVGRSVDAMTELEQESDKIGKVMDVIKAV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
AEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQQSTVEIETLVAALQSGTRQV
HHHCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIMLNSRELTVSSVTLSRQAGTSLGSITQTVSSIQAMNQQIAAAAEEQSAVAEEISRSI
HHHHHCCCCEEEHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNVRDVSEQTASASEETAASSVELARLGGQLQTMVSRFRI
HHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHCC
>Mature Secondary Structure 
SSWFANISVNMKLALGFGLVLVFTAILALTGWTSMSGLINRSNWMSDITSLNAQLTKLR
CCEEEEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]