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The map label for this gene is php [H]

Identifier: 66044028

GI number: 66044028

Start: 877506

End: 878621

Strand: Reverse

Name: php [H]

Synonym: Psyr_0773

Alternate gene names: 66044028

Gene position: 878621-877506 (Counterclockwise)

Preceding gene: 66044029

Following gene: 66044027

Centisome position: 14.42

GC content: 62.01

Gene sequence:

>1116_bases
ATGAGCCTGTTTCGTCACCCTTCACCCCTGCCCCTCGGGGTCGACAGCGGCCATGCCATGACGGTGCTGGGGCCGGTGCC
GGTCGAGCGCCTTGGCGTCACCCTGATGCACGAACACATTCTGCTCGACGCTTCGGGCAAGTGGGTGGCACCCAGTTGCT
GCGGCGAGCGACACCTGGCCGAGCGCCCGGTGAGCATTGAGCTGCTTGGCGAACTGCACATGAACCCGTTGGTCAGCCGC
GACAACTGTCAGTTGTTCGATGTCGATCTGGCCTGTGAGGAGCTGCTGAAGTACCGGGCGCTGGGCGGGGAAACGGTGGT
TGATCCGACCAATCTGGGCATCGGCCGCGACCCGCAGGCCTTGCAGCGAATTTCCCGTCTGACCGGCCTGAATATCATCA
TGGGTGCCGGTTTCTATCTGGAACCCTCGCACCCGCATTACGTGCATGAACGCTCGGTGGAACAGCTGGCGGAGCAGATC
ATTCATGACGTGGGTGGTGGTGAAGAGAAGCCCGAGGTGATTGCCGGCCTGATCGGCGAGATTGGTGTTTCTGCCGCGTT
CACGGCTGACGAAGAGAAATCACTGCGCGCCGCAGCCCGTGCAAGTGCCGCGACCGGCGTGCCGCTTTCAGTGCACTTGC
CAGGCTGGGAGCGTCTCGGCCACCGGGTACTGGACATCGTTGAGGCAGAAGGCGCCGACCTGCGCCACACGGTGCTGTGC
CACATGAACCCGAGCCACAGCGATCCGGCGTATCAGCATGCGCTGGCGGCACGCGGCGCGTTTCTGGAATACGACATGAT
CGGCATGGGTTACTACTTCGCCGACGAGCACGCGCAGTCGCCCAGCGATGAGGAAAACGCACGGGCCATCGTCGCCCTGA
TCGAGCACGGCTTCGGCTCGCAGGTGCTGTTGTCTCAGGACGTCTTTCTGAAAACCATGCTGACTCGCTATGGCGGTCAT
GGTTATGGCTACCTGCTGAAACACTTTGTCCCGCGCCTGCGCCGTCATGGCGTTACCGGCGAACAACTCGAAAACCTTTT
GATCGACAACCCGCGCCGGGTCTTCCAGCGCGGCTTCCAGGCTCCTTTTTCATCGCAGAGGAATGCAACGTCATGA

Upstream 100 bases:

>100_bases
CGTTTTACACGCAAATCGCCACGGGCCTGATCGTACTGCTGGCGATCTGGCTGAACACACGCATTCTACGTACCGGCCGT
CCACTCGGGAGGGCTGGAGC

Downstream 100 bases:

>100_bases
AACAGTCCGTATTGCTGGCTGGCGAATCATGGGTCAGCACGTCAACCCACATCAAAGGCTTCGATCAGTTCGACAGCGTC
ACTGCGCACAATGGCGCGCG

Product: aryldialkylphosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSLFRHPSPLPLGVDSGHAMTVLGPVPVERLGVTLMHEHILLDASGKWVAPSCCGERHLAERPVSIELLGELHMNPLVSR
DNCQLFDVDLACEELLKYRALGGETVVDPTNLGIGRDPQALQRISRLTGLNIIMGAGFYLEPSHPHYVHERSVEQLAEQI
IHDVGGGEEKPEVIAGLIGEIGVSAAFTADEEKSLRAAARASAATGVPLSVHLPGWERLGHRVLDIVEAEGADLRHTVLC
HMNPSHSDPAYQHALAARGAFLEYDMIGMGYYFADEHAQSPSDEENARAIVALIEHGFGSQVLLSQDVFLKTMLTRYGGH
GYGYLLKHFVPRLRRHGVTGEQLENLLIDNPRRVFQRGFQAPFSSQRNATS

Sequences:

>Translated_371_residues
MSLFRHPSPLPLGVDSGHAMTVLGPVPVERLGVTLMHEHILLDASGKWVAPSCCGERHLAERPVSIELLGELHMNPLVSR
DNCQLFDVDLACEELLKYRALGGETVVDPTNLGIGRDPQALQRISRLTGLNIIMGAGFYLEPSHPHYVHERSVEQLAEQI
IHDVGGGEEKPEVIAGLIGEIGVSAAFTADEEKSLRAAARASAATGVPLSVHLPGWERLGHRVLDIVEAEGADLRHTVLC
HMNPSHSDPAYQHALAARGAFLEYDMIGMGYYFADEHAQSPSDEENARAIVALIEHGFGSQVLLSQDVFLKTMLTRYGGH
GYGYLLKHFVPRLRRHGVTGEQLENLLIDNPRRVFQRGFQAPFSSQRNATS
>Mature_370_residues
SLFRHPSPLPLGVDSGHAMTVLGPVPVERLGVTLMHEHILLDASGKWVAPSCCGERHLAERPVSIELLGELHMNPLVSRD
NCQLFDVDLACEELLKYRALGGETVVDPTNLGIGRDPQALQRISRLTGLNIIMGAGFYLEPSHPHYVHERSVEQLAEQII
HDVGGGEEKPEVIAGLIGEIGVSAAFTADEEKSLRAAARASAATGVPLSVHLPGWERLGHRVLDIVEAEGADLRHTVLCH
MNPSHSDPAYQHALAARGAFLEYDMIGMGYYFADEHAQSPSDEENARAIVALIEHGFGSQVLLSQDVFLKTMLTRYGGHG
YGYLLKHFVPRLRRHGVTGEQLENLLIDNPRRVFQRGFQAPFSSQRNATS

Specific function: Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates:P- nitrophenyl acetate, L-alan

COG id: COG1735

COG function: function code R; Predicted metal-dependent hydrolase with the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphotriesterase family [H]

Homologues:

Organism=Homo sapiens, GI20070186, Length=341, Percent_Identity=34.3108504398827, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI47933341, Length=341, Percent_Identity=34.3108504398827, Blast_Score=198, Evalue=5e-51,
Organism=Escherichia coli, GI1789780, Length=327, Percent_Identity=29.3577981651376, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24645325, Length=340, Percent_Identity=26.4705882352941, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017947
- InterPro:   IPR001559 [H]

Pfam domain/function: PF02126 PTE [H]

EC number: NA

Molecular weight: Translated: 40667; Mature: 40536

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01322 PHOSPHOTRIESTERASE_1 ; PS01323 PHOSPHOTRIESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFRHPSPLPLGVDSGHAMTVLGPVPVERLGVTLMHEHILLDASGKWVAPSCCGERHLA
CCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHEEEEEEEECCCCEECHHHCCCHHHH
ERPVSIELLGELHMNPLVSRDNCQLFDVDLACEELLKYRALGGETVVDPTNLGIGRDPQA
CCCCEEEEEHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
LQRISRLTGLNIIMGAGFYLEPSHPHYVHERSVEQLAEQIIHDVGGGEEKPEVIAGLIGE
HHHHHHHCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IGVSAAFTADEEKSLRAAARASAATGVPLSVHLPGWERLGHRVLDIVEAEGADLRHTVLC
HCCCEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEE
HMNPSHSDPAYQHALAARGAFLEYDMIGMGYYFADEHAQSPSDEENARAIVALIEHGFGS
ECCCCCCCHHHHHHHHHCCCEEEEEEEECCEEECHHHCCCCCCCHHHHHHHHHHHCCCCC
QVLLSQDVFLKTMLTRYGGHGYGYLLKHFVPRLRRHGVTGEQLENLLIDNPRRVFQRGFQ
EEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCC
APFSSQRNATS
CCCCCCCCCCC
>Mature Secondary Structure 
SLFRHPSPLPLGVDSGHAMTVLGPVPVERLGVTLMHEHILLDASGKWVAPSCCGERHLA
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHEEEEEEEECCCCEECHHHCCCHHHH
ERPVSIELLGELHMNPLVSRDNCQLFDVDLACEELLKYRALGGETVVDPTNLGIGRDPQA
CCCCEEEEEHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
LQRISRLTGLNIIMGAGFYLEPSHPHYVHERSVEQLAEQIIHDVGGGEEKPEVIAGLIGE
HHHHHHHCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IGVSAAFTADEEKSLRAAARASAATGVPLSVHLPGWERLGHRVLDIVEAEGADLRHTVLC
HCCCEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEE
HMNPSHSDPAYQHALAARGAFLEYDMIGMGYYFADEHAQSPSDEENARAIVALIEHGFGS
ECCCCCCCHHHHHHHHHCCCEEEEEEEECCEEECHHHCCCCCCCHHHHHHHHHHHCCCCC
QVLLSQDVFLKTMLTRYGGHGYGYLLKHFVPRLRRHGVTGEQLENLLIDNPRRVFQRGFQ
EEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCC
APFSSQRNATS
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 9548740 [H]