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The map label for this gene is ispA [H]

Identifier: 66043872

GI number: 66043872

Start: 695679

End: 696566

Strand: Reverse

Name: ispA [H]

Synonym: Psyr_0605

Alternate gene names: 66043872

Gene position: 696566-695679 (Counterclockwise)

Preceding gene: 66043873

Following gene: 66043871

Centisome position: 11.43

GC content: 65.2

Gene sequence:

>888_bases
ATGATCGCGAGCTATCAAGCGCAAAGCCAGACTCGCGTCAACGCAGCACTCGACGGGCTGTTCAAGGCTCCGGGCCCTGA
GCTCGAACGCCTCTACCAAGCCATGCGCTACAGCGTGATGAACGGCGGCAAGCGCGTGCGCCCGCTGCTCGCGTATGCCG
CCTGCGAAGCACTGGGCGGTGTAGCCGAGGATGCCAACGGCGCCGCCTGTGCCGTTGAACTGATTCATGCCTATTCGCTG
GTACATGACGATTTGCCGGCAATGGACGACGACGACCTGCGTCGCGGTCAGCCGACCACGCACAAGGCCTTCGATGAAGC
CTGCGCGATCCTCGCCGGTGACGGCCTGCAAAGCCTGGCTTTCACGGCCCTGCTCGCCCCTCACCTGACGTCACGCGATG
CCGAGACGCGTCTGCAGATGGTCACGGCCCTCGCGACTGCGGCCGGACCGGCGGGCATGGTGGGTGGTCAGGCTATCGAT
CTGGGTTCAGTGGGGCTGAAGCTCGATCAGGCCGCGCTGGAATACATGCATCGCCACAAGACCGGCGCATTGATCGAAGC
CAGCGTTCGGCTTGGCGCACTGGCCAGCGGTCACGCCGATCAGCCGCGCCTCGATGCTCTGCAGGTCTACGCGCGGGCAA
TCGGCCTGGCGTTTCAGGTTCAGGACGACATTCTCGATGTCGAAAGCGATACCGCGACGCTCGGCAAGCGCCAGGGCGCC
GACATCGCTCGCGACAAGCCGACCTACCCGGCGCTGCTGGGCCTGGAAGCGGCCAAGCACTATGCACTGGAACTGCGTGA
TCAGGCGCTGCAAGCGCTGAGCCCGTTCGATGCCGCCGCAGAGCCGTTGCGCCAGCTGGCACGCTACATCGTCGAACGTC
GCCACTGA

Upstream 100 bases:

>100_bases
GCCAGAGCGCCCTCACCCAGGCCGAGCAGAAGGTTCAGGTGCTGCTGGAGCGCGATGGCGAGCTGAGCGAAGAGCCGTTC
GACGATGCGGAACTCCCCGA

Downstream 100 bases:

>100_bases
TCACTGTCACCGGACCGGAAAATCCGCTGAATCAACCACGCCTCATCGTGGTCTCAGTCATTACACATGTCAGCCGGCAG
ATCATCCGCCGACTCACTTC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIASYQAQSQTRVNAALDGLFKAPGPELERLYQAMRYSVMNGGKRVRPLLAYAACEALGGVAEDANGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLAFTALLAPHLTSRDAETRLQMVTALATAAGPAGMVGGQAID
LGSVGLKLDQAALEYMHRHKTGALIEASVRLGALASGHADQPRLDALQVYARAIGLAFQVQDDILDVESDTATLGKRQGA
DIARDKPTYPALLGLEAAKHYALELRDQALQALSPFDAAAEPLRQLARYIVERRH

Sequences:

>Translated_295_residues
MIASYQAQSQTRVNAALDGLFKAPGPELERLYQAMRYSVMNGGKRVRPLLAYAACEALGGVAEDANGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLAFTALLAPHLTSRDAETRLQMVTALATAAGPAGMVGGQAID
LGSVGLKLDQAALEYMHRHKTGALIEASVRLGALASGHADQPRLDALQVYARAIGLAFQVQDDILDVESDTATLGKRQGA
DIARDKPTYPALLGLEAAKHYALELRDQALQALSPFDAAAEPLRQLARYIVERRH
>Mature_295_residues
MIASYQAQSQTRVNAALDGLFKAPGPELERLYQAMRYSVMNGGKRVRPLLAYAACEALGGVAEDANGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLAFTALLAPHLTSRDAETRLQMVTALATAAGPAGMVGGQAID
LGSVGLKLDQAALEYMHRHKTGALIEASVRLGALASGHADQPRLDALQVYARAIGLAFQVQDDILDVESDTATLGKRQGA
DIARDKPTYPALLGLEAAKHYALELRDQALQALSPFDAAAEPLRQLARYIVERRH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=253, Percent_Identity=30.0395256916996, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786623, Length=283, Percent_Identity=54.0636042402827, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1789578, Length=254, Percent_Identity=31.496062992126, Blast_Score=105, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651612, Length=242, Percent_Identity=30.1652892561983, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31463; Mature: 31463

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASYQAQSQTRVNAALDGLFKAPGPELERLYQAMRYSVMNGGKRVRPLLAYAACEALGG
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
VAEDANGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHH
FTALLAPHLTSRDAETRLQMVTALATAAGPAGMVGGQAIDLGSVGLKLDQAALEYMHRHK
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHC
TGALIEASVRLGALASGHADQPRLDALQVYARAIGLAFQVQDDILDVESDTATLGKRQGA
CCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHCCCCCHHHHHHHCCC
DIARDKPTYPALLGLEAAKHYALELRDQALQALSPFDAAAEPLRQLARYIVERRH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIASYQAQSQTRVNAALDGLFKAPGPELERLYQAMRYSVMNGGKRVRPLLAYAACEALGG
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
VAEDANGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHH
FTALLAPHLTSRDAETRLQMVTALATAAGPAGMVGGQAIDLGSVGLKLDQAALEYMHRHK
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHC
TGALIEASVRLGALASGHADQPRLDALQVYARAIGLAFQVQDDILDVESDTATLGKRQGA
CCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHCCCCCHHHHHHHCCC
DIARDKPTYPALLGLEAAKHYALELRDQALQALSPFDAAAEPLRQLARYIVERRH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]