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The map label for this gene is dxs [H]

Identifier: 66043871

GI number: 66043871

Start: 693625

End: 695517

Strand: Reverse

Name: dxs [H]

Synonym: Psyr_0604

Alternate gene names: 66043871

Gene position: 695517-693625 (Counterclockwise)

Preceding gene: 66043872

Following gene: 66043870

Centisome position: 11.41

GC content: 63.13

Gene sequence:

>1893_bases
ATGCCCACGACGTTCAAAGAGATCCCCCGCGAGCGCCCGGTCACGCCGTTGCTCGACCGAGCCGATACCCCGCACGGCCT
GCGCCGTCTGGGCGAAGCCGAGCTGGAAACCCTGGCCGATGAACTGCGCCTGGAATTGCTGTATTCCGTTGGCCAGACCG
GAGGGCATTTTGGTGCCGGCCTCGGGGTCATCGAGCTGACCATCGCGCTGCATTACGTTTTCGACACCCCGGACGACCGT
CTGGTGTGGGACGTGGGTCATCAAGCCTATCCGCACAAGATCCTCACCGGCCGTCGTGCGCGCATGTCCACCCTGCGCCA
GAAGGAAGGGGTTGCCGCCTTTCCGCGTCGCAGCGAAAGCGAGTACGACACCTTTGGTGTCGGGCACTCCAGCACCTCGA
TCAGCGCCGCGCTGGGCATGGCGATTGCATCGCGCCTGCAGGGCAGCGAGCGCAAATCGATTGCCGTGATCGGCGACGGC
GCGCTGACTGCCGGTATGGCCTTCGAAGCGCTGAACCACGCGCCGGAAGTGGCCGCCGACATGCTGGTCATTCTCAACGA
CAACGACATGTCGATCTCGCGTAATGTCGGCGGGCTGTCGAACTACCTGGCCAAGATTCTTTCCAGCCGCACCTACAGCA
GCATGCGTGAAGGCAGCAAAAAGGTGCTTTCGCGCCTGCCCGGAGCATGGGAAATCGCGCGGCGCACCGAAGAGTACGCC
AAAGGCATGCTGGTCCCGGGCACGCTCTTCGAAGAGCTGGGCTGGAACTACATCGGTCCTATCGACGGCCACGACCTGCC
GACCCTGATCGCCACGCTGCGCAACATGCGTGACCTGAAGGGCCCTCAGTTTCTGCATGTGGTGACCAAGAAGGGCAAGG
GGTTTGCGCCGGCCGAAGTCGATCCGATCGGCTATCACGCCATTACCAAGCTCGAGCCGCTGAATGCGCCTGCCGCGCAG
AAAAAGATCAGCGCACCGAAATATTCCGGCGTGTTCGGCCAGTGGATCTGTGACATGGCCGACGCTGACGCACGGCTGGT
CGGCATCACGCCCGCGATGAAGGAAGGTTCGGATCTGGTCGCGTTCAGCGAACGCTTCCCCGAGCGCTACTTCGACGTGG
CCATCGCCGAACAACACGCAGTGACCCTGGCGGCCGGTATGGCGTGCGAAGGCAGCAAGCCGGTGGTGGCGATCTATTCG
ACCTTCCTGCAGCGTGGCTACGATCAGCTGATTCACGACGTCGCGGTACAGAACCTCGACGTGCTGTTCGCCATCGACCG
CGCCGGACTGGTGGGCGAAGACGGCCCGACTCACGCGGGCAGCTTCGACCTCTCCTACCTGCGCTGCATCCCCGGCATGC
TGGTGATGACACCTAGCGATGAAAACGAACTGCGCAAACTGCTCAGCACCGGTTACCTGCATACCGGTCCTGCAGCAGTG
CGCTATCCGCGCGGCACCGGCCCTAACGCGGTGATCGAGGCCAGTCTTGACCCGCTCGAGATCGGCAAGGGCGTTGTGCG
GCGTCAGGGCCAGGGCGTTGCGATACTGGCGTTCGGCGTGCAACTGGCCGAAGCGCTGGTGGTGGCCGAGAAGCTCGACG
CAACGGTGATCGACATGCGTTTCGTCAAACCACTGGACGAAGCCCTGGTCAGCGAAGCTGCCGCCAATCACGAGTTGCTG
GTCACACTGGAAGAAAACGCCGTCATGGGCGGTGCCGGTGCTGCGGTCAGCGAGTTTCTGGCACGCGCCAATATCCTCAA
GTCGGTATTGCACCTGGGCCTGCCGGATGTCTACGTCGAGCATGCCAAGCCTGCGCAGATGCTCACCGAGTGCGGCCTGG
ATGCCCAAGGGATCGAAGCCGCGATCAATGAGCGACTGGCGCTGATTGGCTGA

Upstream 100 bases:

>100_bases
TACACATGTCAGCCGGCAGATCATCCGCCGACTCACTTCATGGGCAGCGTGCGATGCATAAGGTAAACTGCCGCCTCTTT
TACTTATAACGATTCGCCTG

Downstream 100 bases:

>100_bases
CTGCCAGAGCTTCCTCACGCGCCTGGCGTGAGGAACGATCATCACCCGCCCTCGTGCAGCAATCCTGATAACATGCTGCG
CACCTCGACACTGCCGCGAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MPTTFKEIPRERPVTPLLDRADTPHGLRRLGEAELETLADELRLELLYSVGQTGGHFGAGLGVIELTIALHYVFDTPDDR
LVWDVGHQAYPHKILTGRRARMSTLRQKEGVAAFPRRSESEYDTFGVGHSSTSISAALGMAIASRLQGSERKSIAVIGDG
ALTAGMAFEALNHAPEVAADMLVILNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYA
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHVVTKKGKGFAPAEVDPIGYHAITKLEPLNAPAAQ
KKISAPKYSGVFGQWICDMADADARLVGITPAMKEGSDLVAFSERFPERYFDVAIAEQHAVTLAAGMACEGSKPVVAIYS
TFLQRGYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKLLSTGYLHTGPAAV
RYPRGTGPNAVIEASLDPLEIGKGVVRRQGQGVAILAFGVQLAEALVVAEKLDATVIDMRFVKPLDEALVSEAAANHELL
VTLEENAVMGGAGAAVSEFLARANILKSVLHLGLPDVYVEHAKPAQMLTECGLDAQGIEAAINERLALIG

Sequences:

>Translated_630_residues
MPTTFKEIPRERPVTPLLDRADTPHGLRRLGEAELETLADELRLELLYSVGQTGGHFGAGLGVIELTIALHYVFDTPDDR
LVWDVGHQAYPHKILTGRRARMSTLRQKEGVAAFPRRSESEYDTFGVGHSSTSISAALGMAIASRLQGSERKSIAVIGDG
ALTAGMAFEALNHAPEVAADMLVILNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYA
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHVVTKKGKGFAPAEVDPIGYHAITKLEPLNAPAAQ
KKISAPKYSGVFGQWICDMADADARLVGITPAMKEGSDLVAFSERFPERYFDVAIAEQHAVTLAAGMACEGSKPVVAIYS
TFLQRGYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKLLSTGYLHTGPAAV
RYPRGTGPNAVIEASLDPLEIGKGVVRRQGQGVAILAFGVQLAEALVVAEKLDATVIDMRFVKPLDEALVSEAAANHELL
VTLEENAVMGGAGAAVSEFLARANILKSVLHLGLPDVYVEHAKPAQMLTECGLDAQGIEAAINERLALIG
>Mature_629_residues
PTTFKEIPRERPVTPLLDRADTPHGLRRLGEAELETLADELRLELLYSVGQTGGHFGAGLGVIELTIALHYVFDTPDDRL
VWDVGHQAYPHKILTGRRARMSTLRQKEGVAAFPRRSESEYDTFGVGHSSTSISAALGMAIASRLQGSERKSIAVIGDGA
LTAGMAFEALNHAPEVAADMLVILNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYAK
GMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHVVTKKGKGFAPAEVDPIGYHAITKLEPLNAPAAQK
KISAPKYSGVFGQWICDMADADARLVGITPAMKEGSDLVAFSERFPERYFDVAIAEQHAVTLAAGMACEGSKPVVAIYST
FLQRGYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKLLSTGYLHTGPAAVR
YPRGTGPNAVIEASLDPLEIGKGVVRRQGQGVAILAFGVQLAEALVVAEKLDATVIDMRFVKPLDEALVSEAAANHELLV
TLEENAVMGGAGAAVSEFLARANILKSVLHLGLPDVYVEHAKPAQMLTECGLDAQGIEAAINERLALIG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=530, Percent_Identity=25.4716981132075, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI4507521, Length=530, Percent_Identity=25.4716981132075, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI133778974, Length=423, Percent_Identity=26.4775413711584, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637461, Length=378, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637459, Length=378, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637463, Length=378, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1786622, Length=615, Percent_Identity=60.9756097560976, Blast_Score=767, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=409, Percent_Identity=28.6063569682152, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24666278, Length=622, Percent_Identity=26.0450160771704, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45551847, Length=640, Percent_Identity=25.15625, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45550715, Length=640, Percent_Identity=25.15625, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645119, Length=599, Percent_Identity=25.542570951586, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67861; Mature: 67729

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTFKEIPRERPVTPLLDRADTPHGLRRLGEAELETLADELRLELLYSVGQTGGHFGAG
CCCCHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LGVIELTIALHYVFDTPDDRLVWDVGHQAYPHKILTGRRARMSTLRQKEGVAAFPRRSES
HHHHHHEEHHEEEECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCC
EYDTFGVGHSSTSISAALGMAIASRLQGSERKSIAVIGDGALTAGMAFEALNHAPEVAAD
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHC
MLVILNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYA
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHVVTKKGKGFAPAEV
CCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
DPIGYHAITKLEPLNAPAAQKKISAPKYSGVFGQWICDMADADARLVGITPAMKEGSDLV
CCCCCHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
AFSERFPERYFDVAIAEQHAVTLAAGMACEGSKPVVAIYSTFLQRGYDQLIHDVAVQNLD
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCE
VLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKLLSTGYLHTGPAAV
EEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEE
RYPRGTGPNAVIEASLDPLEIGKGVVRRQGQGVAILAFGVQLAEALVVAEKLDATVIDMR
ECCCCCCCCCEEECCCCHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHH
FVKPLDEALVSEAAANHELLVTLEENAVMGGAGAAVSEFLARANILKSVLHLGLPDVYVE
HHHHHHHHHHHHHCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
HAKPAQMLTECGLDAQGIEAAINERLALIG
CCCHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTTFKEIPRERPVTPLLDRADTPHGLRRLGEAELETLADELRLELLYSVGQTGGHFGAG
CCCHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LGVIELTIALHYVFDTPDDRLVWDVGHQAYPHKILTGRRARMSTLRQKEGVAAFPRRSES
HHHHHHEEHHEEEECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCC
EYDTFGVGHSSTSISAALGMAIASRLQGSERKSIAVIGDGALTAGMAFEALNHAPEVAAD
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHC
MLVILNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYA
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHVVTKKGKGFAPAEV
CCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
DPIGYHAITKLEPLNAPAAQKKISAPKYSGVFGQWICDMADADARLVGITPAMKEGSDLV
CCCCCHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
AFSERFPERYFDVAIAEQHAVTLAAGMACEGSKPVVAIYSTFLQRGYDQLIHDVAVQNLD
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCE
VLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKLLSTGYLHTGPAAV
EEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEE
RYPRGTGPNAVIEASLDPLEIGKGVVRRQGQGVAILAFGVQLAEALVVAEKLDATVIDMR
ECCCCCCCCCEEECCCCHHHHCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHH
FVKPLDEALVSEAAANHELLVTLEENAVMGGAGAAVSEFLARANILKSVLHLGLPDVYVE
HHHHHHHHHHHHHCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
HAKPAQMLTECGLDAQGIEAAINERLALIG
CCCHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]