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The map label for this gene is ahcY [H]

Identifier: 66043727

GI number: 66043727

Start: 498180

End: 499589

Strand: Reverse

Name: ahcY [H]

Synonym: Psyr_0460

Alternate gene names: 66043727

Gene position: 499589-498180 (Counterclockwise)

Preceding gene: 66043729

Following gene: 66043726

Centisome position: 8.2

GC content: 58.72

Gene sequence:

>1410_bases
ATGAGTGCTGTAATGACGCCCGCAGAATTCAATGACTACAAGGTTGCCGATATTTCCCTGGCCGCCTGGGGTCGCCGCGA
AACCATCATCGCCGAATCCGAAATGCCTGCCCTGATGGGTCTGCGTCGCAAATACGCCGGTGATCAGCCGCTGAAAGGCG
CGAAGATTCTCGGTTGCATCCACATGACCATTCAGACCGCCGTACTGATCGAAACCCTGGTTGCCCTGGGTGCCGAAGTT
CGCTGGTCGTCGTGCAACATTTTCTCGACTCAGGACCAGGCTGCTGCGGCCATCGCTGCTGCCGGCATTCCTGTGTTCGC
CTGGAAAGGCGAAACCGAAGAAGAATACGAGTGGTGCATCGAGCAGACCATCCTCAAGGATGGCCAGCCATGGGATGCCA
ACATGATCCTCGACGACGGCGGCGACCTGACCGAGATCATCCACAAGAAATACCCGGCAATGCTGGACAAGATCCACGGC
GTCACCGAAGAAACCACCACGGGCGTGCACCGCCTGCTGGACATGCTGGCCAAGGGCGAGCTGAAAATCCCGGCCATCAA
CGTCAACGACTCGGTGACCAAGAGCAAGAACGACAACAAGTACGGCTGCCGTCACAGCCTGAACGACGCCATCAAGCGCG
GCACCGACCACTTGCTGTCCGGCAAGCAGGCGCTGGTGATCGGCTACGGCGACGTGGGCAAGGGCTCGGCCCAGTCCCTG
CGTCAGGAAGGCATGATCGTCAAAGTGACCGAAGTCGACCCGATCTGCGCCATGCAGGCCTGCATGGACGGTTTCGAGCT
GGTTTCGCCGTTCATCGACGGTGAGAACGACGGCACCGAAGCGAGCATCGACAAGGCACTGTTGGGCAAGATCGACCTGA
TCGTGACCACCACCGGTAACGTCAACGTTTGCGACTCCAACATGCTCAAGGCGCTGAAAAAGCGCGCTGTGGTGTGCAAC
ATCGGTCACTTCGACAACGAAATCGACACCGCTTTCATGCGCAAGAACTGGGCATGGGAAGAAGTGAAGCCACAGGTTCA
CAAGATCCACCGTACCGGCCCAGGCTCGTTCGACGCACAGAACGACGACTACCTGATCCTGCTGGCCGAAGGCCGTCTGG
TAAACCTGGGTAACGCCACTGGCCACCCAAGCCGCATCATGGATGGCTCGTTCGCCAACCAGGTTCTGGCGCAGATCTTC
CTCTTCGAGCAGAAGTACGCCGACCTGGCACCCGCCAAGAAATCCGAGCGCCTGACCGTTGAAGTACTGCCGAAGAAACT
CGACGAAGAAGTGGCCCTGGAAATGGTCCGCGGCTTCGGTGGCGTTGTGACCAAGCTGACCAAGACCCAGGCCGATTACA
TCGGTGTGACCGTCGAAGGTCCGTTCAAGCCAGACGCTTATCGCTATTGA

Upstream 100 bases:

>100_bases
CAGGCTCGGATGGGGCGTTGTTTGCCAGGACGATCCTCGACCGGCAAACCTTAAACGCACAACGGCGCCCATTCGCATTT
TTATGGAATGGAGACTCTCA

Downstream 100 bases:

>100_bases
TAGATAGCTGCAAGCGATAAGCTTCAAGCTGCAAGCAAGTGCAGTTCTCTTGTTTGCAGCTTGAGCTTGACGCTCGTTTC
TTTATCGTTATTACACAGCC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSAVMTPAEFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYAGDQPLKGAKILGCIHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMILDDGGDLTEIIHKKYPAMLDKIHG
VTEETTTGVHRLLDMLAKGELKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
RQEGMIVKVTEVDPICAMQACMDGFELVSPFIDGENDGTEASIDKALLGKIDLIVTTTGNVNVCDSNMLKALKKRAVVCN
IGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGPGSFDAQNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIF
LFEQKYADLAPAKKSERLTVEVLPKKLDEEVALEMVRGFGGVVTKLTKTQADYIGVTVEGPFKPDAYRY

Sequences:

>Translated_469_residues
MSAVMTPAEFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYAGDQPLKGAKILGCIHMTIQTAVLIETLVALGAEV
RWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMILDDGGDLTEIIHKKYPAMLDKIHG
VTEETTTGVHRLLDMLAKGELKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
RQEGMIVKVTEVDPICAMQACMDGFELVSPFIDGENDGTEASIDKALLGKIDLIVTTTGNVNVCDSNMLKALKKRAVVCN
IGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGPGSFDAQNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIF
LFEQKYADLAPAKKSERLTVEVLPKKLDEEVALEMVRGFGGVVTKLTKTQADYIGVTVEGPFKPDAYRY
>Mature_468_residues
SAVMTPAEFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYAGDQPLKGAKILGCIHMTIQTAVLIETLVALGAEVR
WSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMILDDGGDLTEIIHKKYPAMLDKIHGV
TEETTTGVHRLLDMLAKGELKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSLR
QEGMIVKVTEVDPICAMQACMDGFELVSPFIDGENDGTEASIDKALLGKIDLIVTTTGNVNVCDSNMLKALKKRAVVCNI
GHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGPGSFDAQNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIFL
FEQKYADLAPAKKSERLTVEVLPKKLDEEVALEMVRGFGGVVTKLTKTQADYIGVTVEGPFKPDAYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=460, Percent_Identity=56.7391304347826, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI239937451, Length=438, Percent_Identity=55.9360730593607, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI298286489, Length=460, Percent_Identity=48.0434782608696, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI195539337, Length=461, Percent_Identity=48.1561822125813, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI24308043, Length=461, Percent_Identity=48.1561822125813, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI195539349, Length=460, Percent_Identity=48.0434782608696, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI21361647, Length=460, Percent_Identity=47.1739130434783, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17506425, Length=459, Percent_Identity=58.3877995642701, Blast_Score=504, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=472, Percent_Identity=54.6610169491525, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=58.008658008658, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24656245, Length=462, Percent_Identity=47.4025974025974, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45553387, Length=460, Percent_Identity=48.2608695652174, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI45553385, Length=459, Percent_Identity=48.1481481481481, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51421; Mature: 51290

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVMTPAEFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYAGDQPLKGAKILGCI
CCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHH
HMTIQTAVLIETLVALGAEVRWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCI
HHHHHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
EQTILKDGQPWDANMILDDGGDLTEIIHKKYPAMLDKIHGVTEETTTGVHRLLDMLAKGE
HHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
LKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEEEECCCCCCCHHHHH
RQEGMIVKVTEVDPICAMQACMDGFELVSPFIDGENDGTEASIDKALLGKIDLIVTTTGN
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEECCC
VNVCDSNMLKALKKRAVVCNIGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGPGSFDAQ
CEECCHHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHCHHHHHHHCCCCCCCCCC
NDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIFLFEQKYADLAPAKKSERLTV
CCCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
EVLPKKLDEEVALEMVRGFGGVVTKLTKTQADYIGVTVEGPFKPDAYRY
EECCHHCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SAVMTPAEFNDYKVADISLAAWGRRETIIAESEMPALMGLRRKYAGDQPLKGAKILGCI
CCCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHH
HMTIQTAVLIETLVALGAEVRWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCI
HHHHHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
EQTILKDGQPWDANMILDDGGDLTEIIHKKYPAMLDKIHGVTEETTTGVHRLLDMLAKGE
HHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
LKIPAINVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKQALVIGYGDVGKGSAQSL
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCEEEEEECCCCCCCHHHHH
RQEGMIVKVTEVDPICAMQACMDGFELVSPFIDGENDGTEASIDKALLGKIDLIVTTTGN
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEECCC
VNVCDSNMLKALKKRAVVCNIGHFDNEIDTAFMRKNWAWEEVKPQVHKIHRTGPGSFDAQ
CEECCHHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHCHHHHHHHCCCCCCCCCC
NDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIFLFEQKYADLAPAKKSERLTV
CCCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
EVLPKKLDEEVALEMVRGFGGVVTKLTKTQADYIGVTVEGPFKPDAYRY
EECCHHCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA