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The map label for this gene is hemE [H]

Identifier: 66043681

GI number: 66043681

Start: 451965

End: 453029

Strand: Direct

Name: hemE [H]

Synonym: Psyr_0414

Alternate gene names: 66043681

Gene position: 451965-453029 (Clockwise)

Preceding gene: 66043680

Following gene: 66043688

Centisome position: 7.42

GC content: 62.44

Gene sequence:

>1065_bases
ATGACTGCCCTGAAGAACGACCGTTTCCTTCGCGCTTTGCTCAAGCAACCCGTAGACGTCACGCCGGTATGGATGATGCG
TCAGGCAGGTCGTTACCTGCCGGAATACCGCGCCAGCCGCGCCAGTGCCGGGGATTTCATGAGCCTGTGCAAGAACCCGC
AGTTCGCCTGTGAAGTCACCCTGCAGCCGCTGGATCGCTACCCGCTGGACGCGGCGATTCTGTTCTCCGACATCCTGACC
ATTCCTGATGCGATGGGCCAGGGGCTGTACTTCGAAACCGGCGAAGGCCCGCGTTTCAGGAAAACCGTGAGCACACTCGC
TGACATCGAAGCACTGCCGATCCCCGATGCGCAGCAGGATCTGGGCTACGTGATGGATGCGGTCAGCACCATTCGCCGCG
AACTCAACGGTCGTGTACCGCTGATCGGTTTCGCCGGCAGCCCGTGGACGCTGGCGACCTACATGGTCGAGGGCGGTTCG
TCGAAGGACTTCCGCAAGTCCAAGGCCATGCTCTACGACAACCCGCAAGCCATGCACCTGCTGCTCGACAAGCTGGCGCA
GTCAGTCACCTCCTACCTCAATGGCCAGATTCTGGCCGGTGCGCAGGCCGTGCAGATCTTCGACAGCTGGGGCGGCAGCC
TGTCTTCGGCGGCGTATCAGGAGTTCTCGCTGGCCTACATGCGCAAGATCGTCAGCGGCCTGATCCGCGAAAACGACGGG
CGCAAGGTGCCGGTCATCGTCTTCACCAAAGGCGGCGGTCTGTGGCTGGAAAGCATCGCCGACATCGGTGCAGATACTCT
TGGACTGGACTGGACCTGCGACATCGGCGAAGCGCGTCAGCGTGTCGGCAGCAAGGTTTCGCTGCAAGGCAACATGGACC
CGACCGTACTCTACGCCCGCCCGGAAGCCATCCGCCAGGAAGTCGCACGCATCCTTGCCAGCTACGGCAGCGGCACCGGC
CACGTCTTCAACCTCGGCCACGGCATCACCCCTGAAGTCGACCCGGCCAATGCCGGCGCGTTCATCAACGCGGTGCATGA
GTTGTCGGCGCAGTATCACGTGTAG

Upstream 100 bases:

>100_bases
GGCTTGGCAAATCGCCTCGATAGACAAAAGGCACGGCTCTCGCCGTGCCTTTTGCGTCGAGCTCTGAGAAAATGCCGGCA
CTTTTATTGCGGATGCCGAC

Downstream 100 bases:

>100_bases
TTGCCGGGCTGACGATGCGTCGATGCCTCAAGACGCATCGGTCGATTTCAGCGCCGACGACTACGTCGGCGCTTTTTCAT
CCTTAAAGCCTTGCAGCAGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVTLQPLDRYPLDAAILFSDILT
IPDAMGQGLYFETGEGPRFRKTVSTLADIEALPIPDAQQDLGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGS
SKDFRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVSGLIRENDG
RKVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYARPEAIRQEVARILASYGSGTG
HVFNLGHGITPEVDPANAGAFINAVHELSAQYHV

Sequences:

>Translated_354_residues
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVTLQPLDRYPLDAAILFSDILT
IPDAMGQGLYFETGEGPRFRKTVSTLADIEALPIPDAQQDLGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGS
SKDFRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVSGLIRENDG
RKVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYARPEAIRQEVARILASYGSGTG
HVFNLGHGITPEVDPANAGAFINAVHELSAQYHV
>Mature_353_residues
TALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVTLQPLDRYPLDAAILFSDILTI
PDAMGQGLYFETGEGPRFRKTVSTLADIEALPIPDAQQDLGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGSS
KDFRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVSGLIRENDGR
KVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYARPEAIRQEVARILASYGSGTGH
VFNLGHGITPEVDPANAGAFINAVHELSAQYHV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=49.4285714285714, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=72.8045325779037, Blast_Score=545, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320252, Length=358, Percent_Identity=39.1061452513966, Blast_Score=269, Evalue=4e-73,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=41.9540229885057, Blast_Score=294, Evalue=6e-80,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=41.9540229885057, Blast_Score=294, Evalue=7e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38658; Mature: 38526

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCCEEEEEE
LQPLDRYPLDAAILFSDILTIPDAMGQGLYFETGEGPRFRKTVSTLADIEALPIPDAQQD
ECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHH
LGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGSSKDFRKSKAMLYDNPQAMHL
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHCCCEECCHHHHHH
LLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVSGLIRENDG
HHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
RKVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYAR
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHCCCEEEEECCCCCEEEEEC
PEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAVHELSAQYHV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCCEEEEEE
LQPLDRYPLDAAILFSDILTIPDAMGQGLYFETGEGPRFRKTVSTLADIEALPIPDAQQD
ECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHH
LGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGSSKDFRKSKAMLYDNPQAMHL
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHCCCEECCHHHHHH
LLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVSGLIRENDG
HHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
RKVPVIVFTKGGGLWLESIADIGADTLGLDWTCDIGEARQRVGSKVSLQGNMDPTVLYAR
CEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHCCCEEEEECCCCCEEEEEC
PEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAVHELSAQYHV
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA