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The map label for this gene is hslU [H]

Identifier: 66043661

GI number: 66043661

Start: 420627

End: 421964

Strand: Reverse

Name: hslU [H]

Synonym: Psyr_0394

Alternate gene names: 66043661

Gene position: 421964-420627 (Counterclockwise)

Preceding gene: 229170803

Following gene: 66043660

Centisome position: 6.92

GC content: 59.12

Gene sequence:

>1338_bases
ATGTCAATGACTCCCCGCGAAATCGTCCATGAACTCAACCGCCATATTATCGGCCAGGACGATGCCAAGCGCGCCGTGGC
CATTGCCCTGCGCAATCGCTGGCGCCGCATGCAGTTGCCGGAAGAGCTGCGTGTTGAAGTAACCCCCAAGAACATTCTGA
TGATCGGTCCGACCGGTGTCGGCAAAACCGAAATCGCCCGTCGTCTGGCCAAACTCGCCAACGCGCCGTTCATCAAGGTC
GAAGCCACCAAATTCACCGAAGTTGGTTATGTGGGTCGTGATGTAGAGTCGATCATCCGTGATCTGGCCGATGCCGCGAT
CAAGCTGCTGCGCGAACAGGAAATCGTCAAGGTGCGTCACCGTGCCGAAGATGCTGCCGAAGAGCGCATTCTCGACGCCC
TGCTGCCACCGGCCCGGGTCGGCTTCAACGAAGACCCGGCGCAGAGCAGCGATTCCAATACCCGTCAGCTGTTCCGCAAG
CGTCTGCGCGAAGGCCAGCTGGATGATAAGGAAATCGAGATCGAGATCAACGAAGCCGTTGGTGTCGATATCTCCGCGCC
GCCTGGCATGGAGGAGATGACCAATCAGTTGCAGAGCCTGTTTGCCAACATGGGCAAGGGCAAGACCAAGAGCCGCAAAC
TCAAGGTCAAGGAAGCGCTCAAGCTGGTACGCGAAGAAGAAGCGGGCCGTCTGGTCAATGAAGAAGAGCTGAAAGCCAAG
GCGCTGGAAGCGGTCGAACAACACGGCATCGTGTTCATCGACGAAATCGACAAGGTGGCCAAGCGTGGTAATTCGGGCGG
TGTCGACGTGTCCCGTGAAGGCGTGCAGCGCGACCTGCTGCCACTGATCGAAGGCTGCACCGTGAACACCAAACTGGGCA
TGGTCAAGACCGACCATATCCTGTTTATCGCCTCGGGCGCGTTCCATTTGAGCAAGCCGAGTGATCTGGTCCCCGAGCTG
CAAGGCCGTCTGCCGATCCGCGTCGAACTCAAGGCGCTGTCGCCGCAGGACTTCGAGCGCATCCTCAGCGAGCCGCATGC
GTCGTTGACCGAACAGTACCGCGAGCTGCTCAAGACCGAAGGCCTGAAGATCGAGTTCAAGCCTGAAGGCATCAAGCGTC
TGGCCGAGATCGCCTGGCAGGTCAACGAGAAGACCGAGAACATCGGCGCCCGCCGCCTGCACACGCTGCTTGAGCGCCTG
CTCGAGGAAGTCTCGTTCAGCGCCGGTGACCTGGCCATCAGCCCTGACGCAGCGCCGATCGAGATCGACGCGGAATACGT
CAATAGTCACTTGGGTGACCTGGCAGAAAACGAAGACCTGTCGCGTTATATTCTCTGA

Upstream 100 bases:

>100_bases
CATCACCATTGAGGAGCAGGACCTCGCCGGCTAAGCCGCTGCCGGGCCGCACATCTTGCGGCCCCATCGACTTGACCGTA
CCAGAGGACCGTGAATAACC

Downstream 100 bases:

>100_bases
AGCTGCAAGCTATTAGCTGCAAGCTGCAAGCTGCAAGCGGTTGTTCACGCTTGCAGCTTTTTTGCTTCTGCTTGAAGCTT
GCAGCTTAAAACTTGAGGCT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKV
EATKFTEVGYVGRDVESIIRDLADAAIKLLREQEIVKVRHRAEDAAEERILDALLPPARVGFNEDPAQSSDSNTRQLFRK
RLREGQLDDKEIEIEINEAVGVDISAPPGMEEMTNQLQSLFANMGKGKTKSRKLKVKEALKLVREEEAGRLVNEEELKAK
ALEAVEQHGIVFIDEIDKVAKRGNSGGVDVSREGVQRDLLPLIEGCTVNTKLGMVKTDHILFIASGAFHLSKPSDLVPEL
QGRLPIRVELKALSPQDFERILSEPHASLTEQYRELLKTEGLKIEFKPEGIKRLAEIAWQVNEKTENIGARRLHTLLERL
LEEVSFSAGDLAISPDAAPIEIDAEYVNSHLGDLAENEDLSRYIL

Sequences:

>Translated_445_residues
MSMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKV
EATKFTEVGYVGRDVESIIRDLADAAIKLLREQEIVKVRHRAEDAAEERILDALLPPARVGFNEDPAQSSDSNTRQLFRK
RLREGQLDDKEIEIEINEAVGVDISAPPGMEEMTNQLQSLFANMGKGKTKSRKLKVKEALKLVREEEAGRLVNEEELKAK
ALEAVEQHGIVFIDEIDKVAKRGNSGGVDVSREGVQRDLLPLIEGCTVNTKLGMVKTDHILFIASGAFHLSKPSDLVPEL
QGRLPIRVELKALSPQDFERILSEPHASLTEQYRELLKTEGLKIEFKPEGIKRLAEIAWQVNEKTENIGARRLHTLLERL
LEEVSFSAGDLAISPDAAPIEIDAEYVNSHLGDLAENEDLSRYIL
>Mature_444_residues
SMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVE
ATKFTEVGYVGRDVESIIRDLADAAIKLLREQEIVKVRHRAEDAAEERILDALLPPARVGFNEDPAQSSDSNTRQLFRKR
LREGQLDDKEIEIEINEAVGVDISAPPGMEEMTNQLQSLFANMGKGKTKSRKLKVKEALKLVREEEAGRLVNEEELKAKA
LEAVEQHGIVFIDEIDKVAKRGNSGGVDVSREGVQRDLLPLIEGCTVNTKLGMVKTDHILFIASGAFHLSKPSDLVPELQ
GRLPIRVELKALSPQDFERILSEPHASLTEQYRELLKTEGLKIEFKPEGIKRLAEIAWQVNEKTENIGARRLHTLLERLL
EEVSFSAGDLAISPDAAPIEIDAEYVNSHLGDLAENEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=444, Percent_Identity=72.2972972972973, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=47, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=99, Percent_Identity=37.3737373737374, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71982908, Length=99, Percent_Identity=37.3737373737374, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319704, Length=461, Percent_Identity=23.644251626898, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49897; Mature: 49766

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGV
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEECCCCC
GKTEIARRLAKLANAPFIKVEATKFTEVGYVGRDVESIIRDLADAAIKLLREQEIVKVRH
CHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEDAAEERILDALLPPARVGFNEDPAQSSDSNTRQLFRKRLREGQLDDKEIEIEINEAV
HHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCC
GVDISAPPGMEEMTNQLQSLFANMGKGKTKSRKLKVKEALKLVREEEAGRLVNEEELKAK
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALEAVEQHGIVFIDEIDKVAKRGNSGGVDVSREGVQRDLLPLIEGCTVNTKLGMVKTDHI
HHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECEEEECCE
LFIASGAFHLSKPSDLVPELQGRLPIRVELKALSPQDFERILSEPHASLTEQYRELLKTE
EEEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHC
GLKIEFKPEGIKRLAEIAWQVNEKTENIGARRLHTLLERLLEEVSFSAGDLAISPDAAPI
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCE
EIDAEYVNSHLGDLAENEDLSRYIL
EEEHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
SMTPREIVHELNRHIIGQDDAKRAVAIALRNRWRRMQLPEELRVEVTPKNILMIGPTGV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCEEEECCCCC
GKTEIARRLAKLANAPFIKVEATKFTEVGYVGRDVESIIRDLADAAIKLLREQEIVKVRH
CHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAEDAAEERILDALLPPARVGFNEDPAQSSDSNTRQLFRKRLREGQLDDKEIEIEINEAV
HHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCC
GVDISAPPGMEEMTNQLQSLFANMGKGKTKSRKLKVKEALKLVREEEAGRLVNEEELKAK
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ALEAVEQHGIVFIDEIDKVAKRGNSGGVDVSREGVQRDLLPLIEGCTVNTKLGMVKTDHI
HHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECEEEECCE
LFIASGAFHLSKPSDLVPELQGRLPIRVELKALSPQDFERILSEPHASLTEQYRELLKTE
EEEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHC
GLKIEFKPEGIKRLAEIAWQVNEKTENIGARRLHTLLERLLEEVSFSAGDLAISPDAAPI
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCE
EIDAEYVNSHLGDLAENEDLSRYIL
EEEHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA