| Definition | Pseudomonas syringae pv. syringae B728a, complete genome. |
|---|---|
| Accession | NC_007005 |
| Length | 6,093,698 |
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The map label for this gene is lgrC [H]
Identifier: 66043600
GI number: 66043600
Start: 350422
End: 351963
Strand: Direct
Name: lgrC [H]
Synonym: Psyr_0331
Alternate gene names: 66043600
Gene position: 350422-351963 (Clockwise)
Preceding gene: 66043599
Following gene: 66043601
Centisome position: 5.75
GC content: 56.94
Gene sequence:
>1542_bases ATGCAGTTGTTTCATCAGGTTATCGCAGATAACGCCCGTAGATATCCGACCAAGCCGGCCATTATTCTAGACGGGCAGGC GACTTCTTATCGGGAATTGCAACAGCGGGTAGATGACATCGCGTCGTTGCTTGCAACGCTCGGTATCCTCCCTGGCGACC GTGTAGGTCTCTACGCGCCGATCTCCATTGACCTGATCGCAAGCTATCTGGGTATGCTGCAAGCCGGAGTGATCACCGCT GCGACTCATCACACCCTCAGCCGTACCAAGCTGATTCATCAACTCAAGCATTCCGGTGCCCGGGTGCTGATCACCGACTG CACTGATGATTTGCCTGACTTGATCAATGAGGCCGGTCTCGAGCTTGTTTTGCTCACTGTCCCGATTCCAACAGCAATAC CTGGGGTTATTCAACTTGCCGAGGCTGTCTCGGGGTACCGCGATGAAGTGAGCGCCGTAGCCTCATTATTGACCGATGAC CCTGAACGCCCCACATCGATATTTTATACCTCGGGGTCGACCTTCAATCCGAAAGGCGTACTCGTCAATCACCGCATCAT GTTGGCGGCCAGCAGTCGGGTCACTGCTTACCTGGGTAACGAAGCCGATGACCGAATCCTCAGCTACTCAACACTGGCAT CGGACTACGGCGTCTATAACGTAATGATGCCGTTGTACGCAGGGGCTACCAGTGTCATTGAGAGCCGGCCTGCAGGTAGC GCAGAAGAAGTACTCGCGGTCGTCGAACGCGAGGCGGTGACCGCAATGCATGTCTTTCCTCCGGTATTTTGCCTGCTGGC CAATGCCGGACCCGAGTGGCAGGCACGGGTACCTGGCTTGCGTTATATCTCCAGCAGCGGACAGGCCCTTCATAGCCGTC ACATTCAGCGCATTCGCCAGGCGCTGCCTCAGGTGCAGATTTTCTCCAACTACGGACTCACTGAATGCAAGCGCGTGAGC TACCTGCCCCCCGAGGAAATTGATCGCCGGCCAACGTCTGTAGGCAAACCTCTGCCCGGTGTCAGTCTGTACTTGGTGGA CGAGCATGACCGGGTGATCGACCAGCCTGGGCAGGTTGGCGAGTTGCTGGTGACAAGCGACTACCTGATGCTTGAGTACT GGGACATGCCTGAAGCGAACGCCAGAGCCTTTGTTCACAATGCTTTCGGTCACTCGCGGCTGTACCGCTCGGGCGATCTG TTCAAGCAGGACGCAGAGGGCTATCTCTACTATGTTGCCCGCAAGGACGACGTATTTGCGCGCAATATCTGGAACGTGAA CCCACGGGAGATCGAGCAGTGTCTGGCTTCGCACCCGGCGGTCGCCGAGGTGCTGGTGGTGCCGGTCGCTGACGAGTCGG CCGGGCATGTGCCCAAGGCGTGCATCGTGCTTGATAGCGACCACCGTCAGACCAGCGGACAAACGCTGATCGACTATTGC AAGGCGCATCTGGATTGGCACATGGTCCCGACTCAGTGCGTGTTTCTTGAGGCTCTGCCAAAAACCGATTCGGGCAAGTT TTCCGCCAAAGGACTGATCTGA
Upstream 100 bases:
>100_bases TGCCAATAGAGCCTTATACATGGCAAGGTACTTATGTGTCGGTGTGTGCTAAAAAACGTAAGTAATGCCAGGGATGTTTC GCTTAAAAGGAAGTTAAACG
Downstream 100 bases:
>100_bases TAGAAGGAGCTATGCCATGAAGACGTCACTCCAGCCAAATGTCGACACGCCCCTCGACCGTGACCTGCAACAGAGTGCGA TGCTGAAACTTGCAGGACAC
Product: AMP-dependent synthetase and ligase
Products: AMP; diphosphate +an acyl-CoA [C]
Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]
Number of amino acids: Translated: 513; Mature: 513
Protein sequence:
>513_residues MQLFHQVIADNARRYPTKPAIILDGQATSYRELQQRVDDIASLLATLGILPGDRVGLYAPISIDLIASYLGMLQAGVITA ATHHTLSRTKLIHQLKHSGARVLITDCTDDLPDLINEAGLELVLLTVPIPTAIPGVIQLAEAVSGYRDEVSAVASLLTDD PERPTSIFYTSGSTFNPKGVLVNHRIMLAASSRVTAYLGNEADDRILSYSTLASDYGVYNVMMPLYAGATSVIESRPAGS AEEVLAVVEREAVTAMHVFPPVFCLLANAGPEWQARVPGLRYISSSGQALHSRHIQRIRQALPQVQIFSNYGLTECKRVS YLPPEEIDRRPTSVGKPLPGVSLYLVDEHDRVIDQPGQVGELLVTSDYLMLEYWDMPEANARAFVHNAFGHSRLYRSGDL FKQDAEGYLYYVARKDDVFARNIWNVNPREIEQCLASHPAVAEVLVVPVADESAGHVPKACIVLDSDHRQTSGQTLIDYC KAHLDWHMVPTQCVFLEALPKTDSGKFSAKGLI
Sequences:
>Translated_513_residues MQLFHQVIADNARRYPTKPAIILDGQATSYRELQQRVDDIASLLATLGILPGDRVGLYAPISIDLIASYLGMLQAGVITA ATHHTLSRTKLIHQLKHSGARVLITDCTDDLPDLINEAGLELVLLTVPIPTAIPGVIQLAEAVSGYRDEVSAVASLLTDD PERPTSIFYTSGSTFNPKGVLVNHRIMLAASSRVTAYLGNEADDRILSYSTLASDYGVYNVMMPLYAGATSVIESRPAGS AEEVLAVVEREAVTAMHVFPPVFCLLANAGPEWQARVPGLRYISSSGQALHSRHIQRIRQALPQVQIFSNYGLTECKRVS YLPPEEIDRRPTSVGKPLPGVSLYLVDEHDRVIDQPGQVGELLVTSDYLMLEYWDMPEANARAFVHNAFGHSRLYRSGDL FKQDAEGYLYYVARKDDVFARNIWNVNPREIEQCLASHPAVAEVLVVPVADESAGHVPKACIVLDSDHRQTSGQTLIDYC KAHLDWHMVPTQCVFLEALPKTDSGKFSAKGLI >Mature_513_residues MQLFHQVIADNARRYPTKPAIILDGQATSYRELQQRVDDIASLLATLGILPGDRVGLYAPISIDLIASYLGMLQAGVITA ATHHTLSRTKLIHQLKHSGARVLITDCTDDLPDLINEAGLELVLLTVPIPTAIPGVIQLAEAVSGYRDEVSAVASLLTDD PERPTSIFYTSGSTFNPKGVLVNHRIMLAASSRVTAYLGNEADDRILSYSTLASDYGVYNVMMPLYAGATSVIESRPAGS AEEVLAVVEREAVTAMHVFPPVFCLLANAGPEWQARVPGLRYISSSGQALHSRHIQRIRQALPQVQIFSNYGLTECKRVS YLPPEEIDRRPTSVGKPLPGVSLYLVDEHDRVIDQPGQVGELLVTSDYLMLEYWDMPEANARAFVHNAFGHSRLYRSGDL FKQDAEGYLYYVARKDDVFARNIWNVNPREIEQCLASHPAVAEVLVVPVADESAGHVPKACIVLDSDHRQTSGQTLIDYC KAHLDWHMVPTQCVFLEALPKTDSGKFSAKGLI
Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an
COG id: COG0318
COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
Gene ontology:
Cell location: Partially Membrane-Associated [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 6 acyl carrier domains [H]
Homologues:
Organism=Homo sapiens, GI156151445, Length=535, Percent_Identity=24.1121495327103, Blast_Score=148, Evalue=1e-35, Organism=Homo sapiens, GI38505220, Length=506, Percent_Identity=25.4940711462451, Blast_Score=120, Evalue=3e-27, Organism=Homo sapiens, GI42544132, Length=519, Percent_Identity=24.8554913294798, Blast_Score=116, Evalue=6e-26, Organism=Homo sapiens, GI187761345, Length=383, Percent_Identity=27.4151436031332, Blast_Score=107, Evalue=2e-23, Organism=Homo sapiens, GI187761343, Length=383, Percent_Identity=27.4151436031332, Blast_Score=107, Evalue=2e-23, Organism=Homo sapiens, GI122937307, Length=516, Percent_Identity=23.8372093023256, Blast_Score=105, Evalue=1e-22, Organism=Homo sapiens, GI115511026, Length=523, Percent_Identity=23.1357552581262, Blast_Score=103, Evalue=4e-22, Organism=Homo sapiens, GI58082049, Length=514, Percent_Identity=21.2062256809339, Blast_Score=97, Evalue=4e-20, Organism=Homo sapiens, GI13375727, Length=545, Percent_Identity=25.5045871559633, Blast_Score=94, Evalue=3e-19, Organism=Homo sapiens, GI157311624, Length=514, Percent_Identity=20.4280155642023, Blast_Score=92, Evalue=1e-18, Organism=Homo sapiens, GI157311622, Length=514, Percent_Identity=20.4280155642023, Blast_Score=92, Evalue=1e-18, Organism=Homo sapiens, GI28416953, Length=509, Percent_Identity=24.5579567779961, Blast_Score=87, Evalue=3e-17, Organism=Homo sapiens, GI195947378, Length=399, Percent_Identity=21.5538847117794, Blast_Score=77, Evalue=3e-14, Organism=Escherichia coli, GI1788107, Length=544, Percent_Identity=28.4926470588235, Blast_Score=168, Evalue=7e-43, Organism=Escherichia coli, GI145693145, Length=510, Percent_Identity=25.4901960784314, Blast_Score=137, Evalue=2e-33, Organism=Escherichia coli, GI221142682, Length=542, Percent_Identity=24.5387453874539, Blast_Score=108, Evalue=1e-24, Organism=Escherichia coli, GI1786801, Length=450, Percent_Identity=24.8888888888889, Blast_Score=98, Evalue=1e-21, Organism=Escherichia coli, GI1786810, Length=502, Percent_Identity=24.9003984063745, Blast_Score=94, Evalue=2e-20, Organism=Escherichia coli, GI1788595, Length=499, Percent_Identity=25.8517034068136, Blast_Score=87, Evalue=4e-18, Organism=Escherichia coli, GI1790505, Length=541, Percent_Identity=23.4750462107209, Blast_Score=82, Evalue=8e-17, Organism=Escherichia coli, GI1786529, Length=554, Percent_Identity=27.0758122743682, Blast_Score=81, Evalue=2e-16, Organism=Caenorhabditis elegans, GI71996755, Length=474, Percent_Identity=25.5274261603376, Blast_Score=147, Evalue=1e-35, Organism=Caenorhabditis elegans, GI17531443, Length=497, Percent_Identity=23.5412474849095, Blast_Score=119, Evalue=3e-27, Organism=Caenorhabditis elegans, GI17557194, Length=540, Percent_Identity=23.7037037037037, Blast_Score=118, Evalue=6e-27, Organism=Caenorhabditis elegans, GI71994703, Length=546, Percent_Identity=22.5274725274725, Blast_Score=115, Evalue=5e-26, Organism=Caenorhabditis elegans, GI71994690, Length=546, Percent_Identity=22.5274725274725, Blast_Score=115, Evalue=5e-26, Organism=Caenorhabditis elegans, GI71994694, Length=546, Percent_Identity=22.5274725274725, Blast_Score=115, Evalue=5e-26, Organism=Caenorhabditis elegans, GI17558820, Length=491, Percent_Identity=24.847250509165, Blast_Score=114, Evalue=9e-26, Organism=Caenorhabditis elegans, GI17538037, Length=527, Percent_Identity=23.3396584440228, Blast_Score=105, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17559526, Length=505, Percent_Identity=23.960396039604, Blast_Score=104, Evalue=1e-22, Organism=Caenorhabditis elegans, GI71985884, Length=416, Percent_Identity=22.8365384615385, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI32563687, Length=510, Percent_Identity=22.5490196078431, Blast_Score=96, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17560308, Length=540, Percent_Identity=23.5185185185185, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17551278, Length=474, Percent_Identity=24.6835443037975, Blast_Score=89, Evalue=5e-18, Organism=Caenorhabditis elegans, GI115534440, Length=515, Percent_Identity=23.8834951456311, Blast_Score=88, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71982997, Length=547, Percent_Identity=23.400365630713, Blast_Score=78, Evalue=9e-15, Organism=Caenorhabditis elegans, GI71983001, Length=547, Percent_Identity=23.400365630713, Blast_Score=78, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17560140, Length=524, Percent_Identity=21.1832061068702, Blast_Score=71, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6319699, Length=344, Percent_Identity=26.453488372093, Blast_Score=114, Evalue=3e-26, Organism=Saccharomyces cerevisiae, GI6319591, Length=499, Percent_Identity=23.4468937875752, Blast_Score=102, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6323182, Length=541, Percent_Identity=23.6598890942699, Blast_Score=97, Evalue=5e-21, Organism=Saccharomyces cerevisiae, GI6319264, Length=550, Percent_Identity=24.1818181818182, Blast_Score=92, Evalue=2e-19, Organism=Drosophila melanogaster, GI24581924, Length=523, Percent_Identity=26.9598470363289, Blast_Score=147, Evalue=2e-35, Organism=Drosophila melanogaster, GI24648260, Length=500, Percent_Identity=26.8, Blast_Score=130, Evalue=3e-30, Organism=Drosophila melanogaster, GI21356947, Length=507, Percent_Identity=22.879684418146, Blast_Score=122, Evalue=8e-28, Organism=Drosophila melanogaster, GI21356441, Length=511, Percent_Identity=25.440313111546, Blast_Score=109, Evalue=4e-24, Organism=Drosophila melanogaster, GI19922652, Length=505, Percent_Identity=23.7623762376238, Blast_Score=108, Evalue=8e-24, Organism=Drosophila melanogaster, GI18859661, Length=459, Percent_Identity=23.3115468409586, Blast_Score=96, Evalue=7e-20, Organism=Drosophila melanogaster, GI24656500, Length=507, Percent_Identity=23.8658777120316, Blast_Score=94, Evalue=2e-19, Organism=Drosophila melanogaster, GI20130357, Length=512, Percent_Identity=24.21875, Blast_Score=94, Evalue=3e-19, Organism=Drosophila melanogaster, GI24648257, Length=479, Percent_Identity=26.5135699373695, Blast_Score=92, Evalue=7e-19, Organism=Drosophila melanogaster, GI21358303, Length=458, Percent_Identity=21.6157205240175, Blast_Score=91, Evalue=2e-18, Organism=Drosophila melanogaster, GI24653035, Length=516, Percent_Identity=22.8682170542636, Blast_Score=87, Evalue=2e-17, Organism=Drosophila melanogaster, GI28573631, Length=549, Percent_Identity=24.2258652094718, Blast_Score=84, Evalue=2e-16, Organism=Drosophila melanogaster, GI20130353, Length=549, Percent_Identity=24.0437158469945, Blast_Score=84, Evalue=3e-16, Organism=Drosophila melanogaster, GI24648253, Length=506, Percent_Identity=22.3320158102767, Blast_Score=81, Evalue=2e-15, Organism=Drosophila melanogaster, GI24648255, Length=506, Percent_Identity=22.5296442687747, Blast_Score=80, Evalue=3e-15, Organism=Drosophila melanogaster, GI161076582, Length=471, Percent_Identity=22.0806794055202, Blast_Score=80, Evalue=5e-15, Organism=Drosophila melanogaster, GI21355181, Length=519, Percent_Identity=19.6531791907514, Blast_Score=67, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR010071 - InterPro: IPR009081 - InterPro: IPR020845 - InterPro: IPR000873 - InterPro: IPR023213 - InterPro: IPR001242 - InterPro: IPR010060 - InterPro: IPR006163 - InterPro: IPR020806 - InterPro: IPR006162 [H]
Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]
EC number: 6.2.1.3 [C]
Molecular weight: Translated: 56367; Mature: 56367
Theoretical pI: Translated: 5.81; Mature: 5.81
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQLFHQVIADNARRYPTKPAIILDGQATSYRELQQRVDDIASLLATLGILPGDRVGLYAP CHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC ISIDLIASYLGMLQAGVITAATHHTLSRTKLIHQLKHSGARVLITDCTDDLPDLINEAGL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCC ELVLLTVPIPTAIPGVIQLAEAVSGYRDEVSAVASLLTDDPERPTSIFYTSGSTFNPKGV EEEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCE LVNHRIMLAASSRVTAYLGNEADDRILSYSTLASDYGVYNVMMPLYAGATSVIESRPAGS EEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHCCCCCC AEEVLAVVEREAVTAMHVFPPVFCLLANAGPEWQARVPGLRYISSSGQALHSRHIQRIRQ HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH ALPQVQIFSNYGLTECKRVSYLPPEEIDRRPTSVGKPLPGVSLYLVDEHDRVIDQPGQVG HCCCEEEECCCCCCHHHHCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCC ELLVTSDYLMLEYWDMPEANARAFVHNAFGHSRLYRSGDLFKQDAEGYLYYVARKDDVFA EEEEECCEEEEEEECCCCCCCHHHHHHHHCHHHHHCCCCCHHCCCCCEEEEEEECCCCHH RNIWNVNPREIEQCLASHPAVAEVLVVPVADESAGHVPKACIVLDSDHRQTSGQTLIDYC HHCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHH KAHLDWHMVPTQCVFLEALPKTDSGKFSAKGLI HHHCCEEECCHHEEEEEECCCCCCCCCCCCCCC >Mature Secondary Structure MQLFHQVIADNARRYPTKPAIILDGQATSYRELQQRVDDIASLLATLGILPGDRVGLYAP CHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC ISIDLIASYLGMLQAGVITAATHHTLSRTKLIHQLKHSGARVLITDCTDDLPDLINEAGL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCC ELVLLTVPIPTAIPGVIQLAEAVSGYRDEVSAVASLLTDDPERPTSIFYTSGSTFNPKGV EEEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCE LVNHRIMLAASSRVTAYLGNEADDRILSYSTLASDYGVYNVMMPLYAGATSVIESRPAGS EEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHCCCCCC AEEVLAVVEREAVTAMHVFPPVFCLLANAGPEWQARVPGLRYISSSGQALHSRHIQRIRQ HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH ALPQVQIFSNYGLTECKRVSYLPPEEIDRRPTSVGKPLPGVSLYLVDEHDRVIDQPGQVG HCCCEEEECCCCCCHHHHCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCC ELLVTSDYLMLEYWDMPEANARAFVHNAFGHSRLYRSGDLFKQDAEGYLYYVARKDDVFA EEEEECCEEEEEEECCCCCCCHHHHHHHHCHHHHHCCCCCHHCCCCCEEEEEEECCCCHH RNIWNVNPREIEQCLASHPAVAEVLVVPVADESAGHVPKACIVLDSDHRQTSGQTLIDYC HHCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHH KAHLDWHMVPTQCVFLEALPKTDSGKFSAKGLI HHHCCEEECCHHEEEEEECCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: Salts [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.0408 {octanoate}} 0.0125 {octanoate}} 0.0059 {octanoate}} 0.00072 {octanoate}} 0.0013 {undecanoate}} 0.0022 {pentadecanoate}} 0.053 {CoA}} 0.035 {CoA}} 0.034 {CoA}} 0.0034 {tridecanoate}} 0.002 {laurate}} 0.0019 {laurate}} 0.0
Substrates: ATP; a long-chain carboxylic acid; CoA [C]
Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate +an acyl-CoA [C]
General reaction: Acid-thiol ligation; Phosphorylation [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA