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The map label for this gene is coaBC [H]

Identifier: 66043491

GI number: 66043491

Start: 235108

End: 236355

Strand: Reverse

Name: coaBC [H]

Synonym: Psyr_0221

Alternate gene names: 66043491

Gene position: 236355-235108 (Counterclockwise)

Preceding gene: 66043493

Following gene: 66043490

Centisome position: 3.88

GC content: 64.82

Gene sequence:

>1248_bases
ATGGCCGTCGTGTGTTCACTCGACCAAAAAGGCAGGTCTATGCAGCGGCTGTATCGAAAACGCATCGTTCTTGGCGTCGG
CGGCGGCATCGCGGCCTACAAGAGCGCTGAACTGGTCCGCCGCCTGCGCGATCAGGGCGCTGAAGTGCGTGTGGTCATGA
CCCGGGGCGGGGCCGAGTTCATCACCCCGCTGACCATGCAGGCCCTGTCCGGGCACCCTGTGCACCTGGACCTTCTCGAT
CCGGCTGCCGAGGCCGCGATGGGCCATATCGAACTGGCCAAATGGGCCGACCTGATCCTCATCGCGCCGGCCACCGCCGA
CCTCATCGCGCGCCTGGCGCAAGGCATCGCCAACGACCTGCTGACCACCATCGTGCTGGCCACCGACGCGACCGTCGCCA
TCGCCCCGGCGATGAACCAGGCGATGTGGCGTGACGCCTCCGTGCAGGCCAATACCCGCCTGCTCGAAGAGCGCGATTTT
CGTGTGTTCGGGCCGGCGTCCGGCAGTCAGGCGTGTGGCGACGTCGGCTTCGGGCGCATGCTGGAGGCCGACGACCTGGC
CCAGTGCGCGGCCGACTGCTTCCAGCGCCTGACCCTGACCGGCAAGCATGTGCTGATCACCGCAGGCCCGACCCAGGAAA
ACATCGACCCGGTGCGCTACATCACCAACCACAGCTCCGGAAAAATGGGCTTTGCCCTGGCCGAAGCGGCGGTGGAAGCC
GGCGCCCGCGTCACGCTGATCACCGGCCCGGTCAACCTGCCTACGCCTGATCGCGTCTCGCGCATCGACGTGGTCAGCGC
CCGCGACATGCTGGCAGCGTGCGAGGCGGCGATCCCCTGCGACCTGTTCATCGCCTCGGCAGCCGTGGCCGACTACCGCC
CGGAAGTCGTTGCCCCGCACAAATTGAAGAAAGATCCTTCGAACGGTGACGGCTTGCTGCTGCAGATGGTGCGCAATCCG
GATATTCTGGCGACCATCGCAACCCGCCCGGATCGCCCCTTCAGTGTCGGCTTTGCCGCCGAGACCGAACACCTGCTCGA
CTACGCTGCCCGCAAGCTCAAGGACAAGAACCTCGACCTGATTGTCGCCAACGATGTCGCGAACCCGAGCATCGGCTTCA
ATAGTGAGGAAAACGCCTGCAGCGTGATTGACCGAGGGTTGCACGCAACGCTTTTCGCCCAGACCAGCAAGGCCAAGATC
GCTCGCCAGCTGGTCACTTTTATCGCCGACCGCATGAATCAGGTTTAA

Upstream 100 bases:

>100_bases
TCATAGCACCTCCATGTGATTGGGCACCGCTGTTCCGGTGCGGTCGCTGTGCTATCTTAGCCCATCTTTTTTGCACGACG
ATCTGGCCTGGGGAGGCGTC

Downstream 100 bases:

>100_bases
CTACGAATGCACGCTCTACAAGCCAAGATCCTCGACCCTCGCATTGGCAACGAATTTCCGCTGCCGGCTTACGCCACTAC
CGGCTCGGCTGGCCTGGACC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAVVCSLDQKGRSMQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLD
PAAEAAMGHIELAKWADLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDF
RVFGPASGSQACGDVGFGRMLEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEA
GARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPHKLKKDPSNGDGLLLQMVRNP
DILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRGLHATLFAQTSKAKI
ARQLVTFIADRMNQV

Sequences:

>Translated_415_residues
MAVVCSLDQKGRSMQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLD
PAAEAAMGHIELAKWADLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDF
RVFGPASGSQACGDVGFGRMLEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEA
GARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPHKLKKDPSNGDGLLLQMVRNP
DILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRGLHATLFAQTSKAKI
ARQLVTFIADRMNQV
>Mature_414_residues
AVVCSLDQKGRSMQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDP
AAEAAMGHIELAKWADLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFR
VFGPASGSQACGDVGFGRMLEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAG
ARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPHKLKKDPSNGDGLLLQMVRNPD
ILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRGLHATLFAQTSKAKIA
RQLVTFIADRMNQV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=31.7919075144509, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87082301, Length=363, Percent_Identity=59.504132231405, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17560194, Length=174, Percent_Identity=31.6091954022989, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324629, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=26.2032085561497, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44439; Mature: 44307

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVCSLDQKGRSMQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTRGGAEF
CEEEECCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHH
ITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWADLILIAPATADLIARLAQGIANDL
HHHHHHHHCCCCCEEEEECCCHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHH
LTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVGFGRM
HHHHHHHCCCCEEEECHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
LEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEA
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHEEECCCCCCHHHHHHHHHHHC
GARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPH
CCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCH
KLKKDPSNGDGLLLQMVRNPDILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDL
HCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCE
IVANDVANPSIGFNSEENACSVIDRGLHATLFAQTSKAKIARQLVTFIADRMNQV
EEECCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVVCSLDQKGRSMQRLYRKRIVLGVGGGIAAYKSAELVRRLRDQGAEVRVVMTRGGAEF
EEEECCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHH
ITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWADLILIAPATADLIARLAQGIANDL
HHHHHHHHCCCCCEEEEECCCHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHH
LTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVGFGRM
HHHHHHHCCCCEEEECHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
LEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEA
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHEEECCCCCCHHHHHHHHHHHC
GARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPH
CCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCH
KLKKDPSNGDGLLLQMVRNPDILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDL
HCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCE
IVANDVANPSIGFNSEENACSVIDRGLHATLFAQTSKAKIARQLVTFIADRMNQV
EEECCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]