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The map label for this gene is argH2 [H]

Identifier: 66043336

GI number: 66043336

Start: 64605

End: 65999

Strand: Direct

Name: argH2 [H]

Synonym: Psyr_0065

Alternate gene names: 66043336

Gene position: 64605-65999 (Clockwise)

Preceding gene: 66043326

Following gene: 66043337

Centisome position: 1.06

GC content: 62.87

Gene sequence:

>1395_bases
ATGAGCACCGACAAGACCAACCAGTCCTGGGGCGGCCGCTTCAGTGAACCCGTCGACGCGTTTGTCGCGCGTTTCACCGC
CTCCGTCACCTTCGATCAACGCCTTTATCGCCACGACATCATGGGCTCCATCGCCCACGCCACAATGCTGGCCAAGGTGG
GCGTACTGACCGACGCCGAGCGCGATACCATCGTTGACGGCCTGAACACCATCCAGGCCGAGATCGAGGCTGGCCAGTTC
GACTGGCGCGTCGATCTGGAAGACGTGCACATGAACATTGAAGCACGCCTGACCGACCGCATCGGTATCACCGGCAAGAA
ACTGCACACCGGTCGCAGCCGCAACGATCAGGTCGCCACCGATATCCGTCTGTGGCTGCGCGACGAAATCGACCTGATCC
TCAGCGAAATCACCCGTCTGCAGCAAGGCCTGCTGGGCCAGGCCGAGCGTGAAGCTGAAACCATCATGCCCGGTTTCACC
CACCTGCAGACGGCCCAGCCGGTAACATTCGGTCACCATATGCTGGCCTGGTTCGAAATGCTCAGCCGCGACTACGAGCG
TCTGGTCGACTGCCGCAAGCGTCTCAACCGCATGCCGCTGGGCAGCGCGGCGCTGGCGGGCACCACCTACCCGATCGACC
GCGAGCTGACCTGCACACTGCTGGGCTTCGAGGTGGTGGGCGGCAACTCGCTGGACGGTGTATCGGATCGCGACTTCGCC
ATCGAATTCTGCTCGGCTGCATCCATCGCAATGATGCACCTGTCGCGCTTTTCGGAAGAGCTGGTGCTCTGGACCAGTGC
GCAGTTCCAGTTCATCGACCTGCCGGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAAAAGAAAAACCCTGACGTCC
CCGAGCTGGTTCGCGGCAAGAGCGGCCGTGTGTTCGGCGCCCTGATGGGCCTGCTGACCCTGATGAAAGGCCAGCCGCTG
GCGTACAACAAGGACAACCAGGAAGACAAGGAGCCGCTGTTCGACGCCGCCGACACACTGCGTGATTCGTTGCGTGCGTT
CGCCGACATGATCCCTGCGATCAAGCCCAGGCACGCAATGATGCGTGAAGCGGCGCTGCGCGGCTTCTCGACCGCGACCG
ATCTGGCCGACTACCTGGTCCGCCGTGGTCTGCCGTTCCGTGACTGCCATGAAATCGTCGGTCACGCGGTGAAATACGGT
GTGGAAACCGGCAAGGACCTGGCAGAGATGAGCCTGGAAGAGCTGCGTCAGTTCAGCAACCAGATCGAACAGGACGTCTT
CGCCGTGCTGACCCTGGAAGGCTCGGTGAATGCCCGCAACCACATCGGCGGCACCGCCCCCGAACAGGTCCGCGCCGCCG
TGATTCGCGGTCAGGAACTGCTGGCCGGGCGCTGA

Upstream 100 bases:

>100_bases
AGCTGTCCGGGGATAAATATGCATCAACCCTGTTATCATCGCGTTCGTTCTTGTGCCAGGTATCGGGCACGTCACTTTCC
AGTCAGCAACGAGCGAATCC

Downstream 100 bases:

>100_bases
ACAGACCCCGCACAGCCCCTGATGACGCGGAGCATTGGCACGATAGAAATCTCAAGGTTTTCATCGTTCCCATGCTCCGC
GTGGGAATGCGCTTCTGGAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase 2 [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSTDKTNQSWGGRFSEPVDAFVARFTASVTFDQRLYRHDIMGSIAHATMLAKVGVLTDAERDTIVDGLNTIQAEIEAGQF
DWRVDLEDVHMNIEARLTDRIGITGKKLHTGRSRNDQVATDIRLWLRDEIDLILSEITRLQQGLLGQAEREAETIMPGFT
HLQTAQPVTFGHHMLAWFEMLSRDYERLVDCRKRLNRMPLGSAALAGTTYPIDRELTCTLLGFEVVGGNSLDGVSDRDFA
IEFCSAASIAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGKSGRVFGALMGLLTLMKGQPL
AYNKDNQEDKEPLFDAADTLRDSLRAFADMIPAIKPRHAMMREAALRGFSTATDLADYLVRRGLPFRDCHEIVGHAVKYG
VETGKDLAEMSLEELRQFSNQIEQDVFAVLTLEGSVNARNHIGGTAPEQVRAAVIRGQELLAGR

Sequences:

>Translated_464_residues
MSTDKTNQSWGGRFSEPVDAFVARFTASVTFDQRLYRHDIMGSIAHATMLAKVGVLTDAERDTIVDGLNTIQAEIEAGQF
DWRVDLEDVHMNIEARLTDRIGITGKKLHTGRSRNDQVATDIRLWLRDEIDLILSEITRLQQGLLGQAEREAETIMPGFT
HLQTAQPVTFGHHMLAWFEMLSRDYERLVDCRKRLNRMPLGSAALAGTTYPIDRELTCTLLGFEVVGGNSLDGVSDRDFA
IEFCSAASIAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGKSGRVFGALMGLLTLMKGQPL
AYNKDNQEDKEPLFDAADTLRDSLRAFADMIPAIKPRHAMMREAALRGFSTATDLADYLVRRGLPFRDCHEIVGHAVKYG
VETGKDLAEMSLEELRQFSNQIEQDVFAVLTLEGSVNARNHIGGTAPEQVRAAVIRGQELLAGR
>Mature_463_residues
STDKTNQSWGGRFSEPVDAFVARFTASVTFDQRLYRHDIMGSIAHATMLAKVGVLTDAERDTIVDGLNTIQAEIEAGQFD
WRVDLEDVHMNIEARLTDRIGITGKKLHTGRSRNDQVATDIRLWLRDEIDLILSEITRLQQGLLGQAEREAETIMPGFTH
LQTAQPVTFGHHMLAWFEMLSRDYERLVDCRKRLNRMPLGSAALAGTTYPIDRELTCTLLGFEVVGGNSLDGVSDRDFAI
EFCSAASIAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGKSGRVFGALMGLLTLMKGQPLA
YNKDNQEDKEPLFDAADTLRDSLRAFADMIPAIKPRHAMMREAALRGFSTATDLADYLVRRGLPFRDCHEIVGHAVKYGV
ETGKDLAEMSLEELRQFSNQIEQDVFAVLTLEGSVNARNHIGGTAPEQVRAAVIRGQELLAGR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=446, Percent_Identity=44.1704035874439, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=446, Percent_Identity=44.1704035874439, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=446, Percent_Identity=41.7040358744395, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI68303549, Length=446, Percent_Identity=41.2556053811659, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1790398, Length=450, Percent_Identity=48.8888888888889, Blast_Score=438, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=43.8053097345133, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=441, Percent_Identity=40.1360544217687, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI78706858, Length=441, Percent_Identity=40.1360544217687, Blast_Score=321, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51821; Mature: 51690

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDKTNQSWGGRFSEPVDAFVARFTASVTFDQRLYRHDIMGSIAHATMLAKVGVLTDAE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RDTIVDGLNTIQAEIEAGQFDWRVDLEDVHMNIEARLTDRIGITGKKLHTGRSRNDQVAT
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCEEEEEHHHCCCCCCCCCCCCCCCCHHHH
DIRLWLRDEIDLILSEITRLQQGLLGQAEREAETIMPGFTHLQTAQPVTFGHHMLAWFEM
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
LSRDYERLVDCRKRLNRMPLGSAALAGTTYPIDRELTCTLLGFEVVGGNSLDGVSDRDFA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHH
IEFCSAASIAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGK
HHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHHHCCCCCCCCCCCCCCCHHHHCCC
SGRVFGALMGLLTLMKGQPLAYNKDNQEDKEPLFDAADTLRDSLRAFADMIPAIKPRHAM
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MREAALRGFSTATDLADYLVRRGLPFRDCHEIVGHAVKYGVETGKDLAEMSLEELRQFSN
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QIEQDVFAVLTLEGSVNARNHIGGTAPEQVRAAVIRGQELLAGR
HHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
STDKTNQSWGGRFSEPVDAFVARFTASVTFDQRLYRHDIMGSIAHATMLAKVGVLTDAE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RDTIVDGLNTIQAEIEAGQFDWRVDLEDVHMNIEARLTDRIGITGKKLHTGRSRNDQVAT
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCEEEEEHHHCCCCCCCCCCCCCCCCHHHH
DIRLWLRDEIDLILSEITRLQQGLLGQAEREAETIMPGFTHLQTAQPVTFGHHMLAWFEM
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
LSRDYERLVDCRKRLNRMPLGSAALAGTTYPIDRELTCTLLGFEVVGGNSLDGVSDRDFA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHH
IEFCSAASIAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGK
HHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHHHCCCCCCCCCCCCCCCHHHHCCC
SGRVFGALMGLLTLMKGQPLAYNKDNQEDKEPLFDAADTLRDSLRAFADMIPAIKPRHAM
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MREAALRGFSTATDLADYLVRRGLPFRDCHEIVGHAVKYGVETGKDLAEMSLEELRQFSN
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QIEQDVFAVLTLEGSVNARNHIGGTAPEQVRAAVIRGQELLAGR
HHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA