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The map label for this gene is fkl [H]

Identifier: 66043326

GI number: 66043326

Start: 56138

End: 56815

Strand: Direct

Name: fkl [H]

Synonym: Psyr_0055

Alternate gene names: 66043326

Gene position: 56138-56815 (Clockwise)

Preceding gene: 66043324

Following gene: 66043336

Centisome position: 0.92

GC content: 63.42

Gene sequence:

>678_bases
ATGTCGCGCTACCTGTTAACGTCGTTGTTCCTCTTGCTACCCCTGGCTCAGGCCGCCGAGGCGCCGCCTGCGTCCAGCGA
CGGCCACGATCTCGCCTACAGCCTGGGTGCAAGCCTCGGCGAGCGGTTGCATCAGGAAGTCCCTGACCTGGACCTCAAGG
CGCTGGTAGAAGGCTTGCAGCAGGCCTATCAGGGCAAGCCGCTGGCGCTCAAGCAGGAACGCATCGACCAGATTCTGCGC
GAGCATGACGCCGCGATCGCCCAGGCCGAGACTGCCGGTACGGATGCGCCGACCGAGGCGGCTCTCAAGGCCGAGCGCAC
GTTCATGGACAGCGAGAAGGCCAAGCCGGGTGTGAAGGTGCTGGCTGACGGGATTCTCATGACCGAGCTGACTCCTGGCA
CCGGCCCCAAGCCCAGTGCCGATGGCCGGGTTGAAGTGCGTTATGTCGGTCGCTTGCCGGACGGCACCATCTTCGATCAG
AGCACCCAGCCCCAGTGGTTCCGGCTCGACAGTGTGATCAGCGGCTGGACCAGCGCCTTGCAGAACATGCCGACCGGCGC
GAAGTGGCGGCTGGTGATCCCTTCGGATCAAGCCTATGGTGCCGAGGGCGCTGGTGATCTGATCGATCCGTTTACGCCAC
TGGTATTTGAAATCGAGCTGGTTGCGGTTTCACAGTAA

Upstream 100 bases:

>100_bases
CGGCACGATGCAAAGGCATTGTGAAATTCACATCACAAGACTCGTCACTACTCGCGCTGGCGCTGGCATAATCGCTGCCT
TCCCAGGCCGGAGAGCATTA

Downstream 100 bases:

>100_bases
GCGGACGGAGACCGGCGTTCAGAAATGCGAAAGGGTGCAATAAGCACCCTTGGCGTGTAGCACTTGCATCAACCAGGTCA
CACCTGAGCGGCGATCTCTT

Product: FKBP-type peptidyl-prolyl isomerase, N-terminal:peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSRYLLTSLFLLLPLAQAAEAPPASSDGHDLAYSLGASLGERLHQEVPDLDLKALVEGLQQAYQGKPLALKQERIDQILR
EHDAAIAQAETAGTDAPTEAALKAERTFMDSEKAKPGVKVLADGILMTELTPGTGPKPSADGRVEVRYVGRLPDGTIFDQ
STQPQWFRLDSVISGWTSALQNMPTGAKWRLVIPSDQAYGAEGAGDLIDPFTPLVFEIELVAVSQ

Sequences:

>Translated_225_residues
MSRYLLTSLFLLLPLAQAAEAPPASSDGHDLAYSLGASLGERLHQEVPDLDLKALVEGLQQAYQGKPLALKQERIDQILR
EHDAAIAQAETAGTDAPTEAALKAERTFMDSEKAKPGVKVLADGILMTELTPGTGPKPSADGRVEVRYVGRLPDGTIFDQ
STQPQWFRLDSVISGWTSALQNMPTGAKWRLVIPSDQAYGAEGAGDLIDPFTPLVFEIELVAVSQ
>Mature_224_residues
SRYLLTSLFLLLPLAQAAEAPPASSDGHDLAYSLGASLGERLHQEVPDLDLKALVEGLQQAYQGKPLALKQERIDQILRE
HDAAIAQAETAGTDAPTEAALKAERTFMDSEKAKPGVKVLADGILMTELTPGTGPKPSADGRVEVRYVGRLPDGTIFDQS
TQPQWFRLDSVISGWTSALQNMPTGAKWRLVIPSDQAYGAEGAGDLIDPFTPLVFEIELVAVSQ

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=197, Percent_Identity=35.5329949238579, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=36.9668246445498, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323566, Length=135, Percent_Identity=34.8148148148148, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=121, Percent_Identity=38.0165289256198, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24208; Mature: 24076

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYLLTSLFLLLPLAQAAEAPPASSDGHDLAYSLGASLGERLHQEVPDLDLKALVEGLQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QAYQGKPLALKQERIDQILREHDAAIAQAETAGTDAPTEAALKAERTFMDSEKAKPGVKV
HHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHH
LADGILMTELTPGTGPKPSADGRVEVRYVGRLPDGTIFDQSTQPQWFRLDSVISGWTSAL
HHCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHH
QNMPTGAKWRLVIPSDQAYGAEGAGDLIDPFTPLVFEIELVAVSQ
HHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
SRYLLTSLFLLLPLAQAAEAPPASSDGHDLAYSLGASLGERLHQEVPDLDLKALVEGLQ
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QAYQGKPLALKQERIDQILREHDAAIAQAETAGTDAPTEAALKAERTFMDSEKAKPGVKV
HHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHH
LADGILMTELTPGTGPKPSADGRVEVRYVGRLPDGTIFDQSTQPQWFRLDSVISGWTSAL
HHCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHH
QNMPTGAKWRLVIPSDQAYGAEGAGDLIDPFTPLVFEIELVAVSQ
HHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2514124; 2110144; 10984043 [H]