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The map label for this gene is hemY [H]

Identifier: 66043330

GI number: 66043330

Start: 58285

End: 59529

Strand: Reverse

Name: hemY [H]

Synonym: Psyr_0059

Alternate gene names: 66043330

Gene position: 59529-58285 (Counterclockwise)

Preceding gene: 66043331

Following gene: 66043329

Centisome position: 0.98

GC content: 63.05

Gene sequence:

>1245_bases
ATGAAGCGCTTCTATGTGCTGTTATTCATCGCGATCGCCGCTGCGGCGCTGATCGGGGTCGCCATCGCCGAGCATTCCGG
CTATGTCCTGATCGCCTATCAGAACTTCCGCTATGAATCGAGTCTGTGGGCAACCCTGGCGTTGCTGGTCGTTGCGTTAC
TGGTGATCGCACTGCTGAGGCTGCTGATCACCCTGCTGACGACCTCAGGCCGCGTGGTCAACCCATGGTCGCGCCGCAAC
CGCCGTCGTCGCGTGCAAATAGCTATCGAGCAAGGCCAGATGGACCTTGCCGAGGGCCGCTGGTCCAGCGCCCAACGTCA
TCTGCAACGCGCCGCCGAAGCCGATACGCATCCGCTGCTCTACTACATCGGCGCTGCACGTGCTGCCAACGAGCAGGGCC
GTTACGAAGACTGCGATGCCTTGCTGGAGCGTGCGCTCGAGCGTCAGCCACAAGCCGAGCTGGCGATTGCCCTGAATCAC
GCTCAACTGCAGCAGGACCGTGGCGACACCGAAGGTGCGCTGACCACACTGCTGGCCATGAAAGAGCGTCATCCGCACAA
CCCACAGGTGCTTCGTCAGTTGCAACGCCTGTATCAGCAACGTGGTGACTGGTCCGATGTGGTTCGCCTGATGCCGGAGC
TGCGCAAGGACAAGGTCCTGCCAGCCAAGGAACTGGCCGAGCTGGAACGCCGCGCCTGGGGCGAAAACCTTAGCCTGGCG
GCGTACCGCGAAGGCATCGAAGGCGCACCGACCGGTCTGCCTTCACTGGAAAGCGCCTGGCAGGGGCTGGGTTCTGCGCA
ACGTCAGGAGCCGCAACTGGTGCTGGCGTATGCCGATCAATTGCGCCGTCTGGGTGCCGAAGCCCAGGCCGAAGAGGTGC
TTCGTAGCGCCCTCAAGCGCGAGTACAACAGCCATCTGGCGCGTCTGTATGGACTGGTTCGCGGCAGCGACCCGTTGAAG
CAGCTGCAAACGGCGGAGGGCTGGCTCAAGCACCATCCAGCTGATCCAAGCCTGTTGCTGAGCCTGGGACGTATCTGTCT
GCAAGGTCGACTGTGGGGCAAGGCGCGGGATTATCTGGAGAGCAGTCTGCGCCTGGAGCGCAATCCCGAAACCTGCGCCG
AGCTGGCTCGCCTGCTCGGCCAACTGGGTGAGACGGATCGCAGCAATCAGCTGTTTCAGGAAGGTCTGGGCCTGCTCGAC
GAGCGCCTCCTGTCGCGCCCCTTGCCGGTGCTGACCAAGGCCTGA

Upstream 100 bases:

>100_bases
AGACACCGGATCTGGCACCAACCCTGAGCGCCGTGCAGGCCTACCTTGAACGCCGTCACGCTGCCGGCCAGCCAGCCGAG
GCGCAACAGGGGACCAGCCG

Downstream 100 bases:

>100_bases
ATCCGCCGGAGAGTCCTCTGTGAGGGCTCTCCGTGCTGCCTCACCAGCCCGTCAAGATCAATGCGTGAGAATCGTCCTAC
ATCCATGTGTAAAAGAACCA

Product: HemY, N-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MKRFYVLLFIAIAAAALIGVAIAEHSGYVLIAYQNFRYESSLWATLALLVVALLVIALLRLLITLLTTSGRVVNPWSRRN
RRRRVQIAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNH
AQLQQDRGDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLA
AYREGIEGAPTGLPSLESAWQGLGSAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLK
QLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLD
ERLLSRPLPVLTKA

Sequences:

>Translated_414_residues
MKRFYVLLFIAIAAAALIGVAIAEHSGYVLIAYQNFRYESSLWATLALLVVALLVIALLRLLITLLTTSGRVVNPWSRRN
RRRRVQIAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNH
AQLQQDRGDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLA
AYREGIEGAPTGLPSLESAWQGLGSAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLK
QLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLD
ERLLSRPLPVLTKA
>Mature_414_residues
MKRFYVLLFIAIAAAALIGVAIAEHSGYVLIAYQNFRYESSLWATLALLVVALLVIALLRLLITLLTTSGRVVNPWSRRN
RRRRVQIAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNH
AQLQQDRGDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLA
AYREGIEGAPTGLPSLESAWQGLGSAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLK
QLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLD
ERLLSRPLPVLTKA

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=385, Percent_Identity=25.1948051948052, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 46634; Mature: 46634

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFYVLLFIAIAAAALIGVAIAEHSGYVLIAYQNFRYESSLWATLALLVVALLVIALLR
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LLITLLTTSGRVVNPWSRRNRRRRVQIAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLL
HHHHHHHCCCCEECCHHHHCCCCEEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCCHH
YYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAM
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLA
HHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
AYREGIEGAPTGLPSLESAWQGLGSAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKR
HHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
SSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLDERLLSRPLPVLTKA
HHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MKRFYVLLFIAIAAAALIGVAIAEHSGYVLIAYQNFRYESSLWATLALLVVALLVIALLR
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LLITLLTTSGRVVNPWSRRNRRRRVQIAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLL
HHHHHHHCCCCEECCHHHHCCCCEEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCCHH
YYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAM
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLA
HHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHH
AYREGIEGAPTGLPSLESAWQGLGSAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKR
HHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
SSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLDERLLSRPLPVLTKA
HHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]