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The map label for this gene is uppS2

Identifier: 62391124

GI number: 62391124

Start: 2388043

End: 2388774

Strand: Reverse

Name: uppS2

Synonym: cg2508

Alternate gene names: 62391124

Gene position: 2388774-2388043 (Counterclockwise)

Preceding gene: 62391125

Following gene: 62391123

Centisome position: 72.77

GC content: 55.46

Gene sequence:

>732_bases
GTGAGTGAATTCCAAGTACCCGAAATCCCTGCCCAATTCCTACCCAAGCATATTGCGCTTGTCATGGATGGAAATGGACG
CTGGGCTACCGAGCGTGGCATGAAGCGCACCGAAGGCCATAAGCGTGGCGAGGCAGTCCTGCTTGATGTTGTTGATGCAT
GCATTGAACTTGGTGTTCCGTACCTTTCTGCTTATGCCTTCTCTACTGAAAACTGGCGTCGTTCCACCGATGAGGTCCGT
TTCCTCATGGGATTCAACCGAGATGTGCTGCGACGACAACGCGATGACCTACATGAAAAGGGCGTTCGTGTGCGTTGGGT
TGGCCGTCGTCCCCGCCTGTGGCGTTCGGTTATCCGTGAGCTGGAAACTGCGGAAGAGCTAACCAAAGACAACACCACCA
TGACCTTGGCCATGTGTGTGAACTATGGTGGACGCGCCGAAATCATCGACGCAGCCCGCGACATCGCCCGCCTTGCAGCT
GAAGGCAAACTGCGCCCGGAACAAATCACTGAGAAGACCTTCCCGAACTTCCTCGACGAACCTGACATGCCAGACGTCGA
CCTGTTCCTGCGCCCATCCGGTGAGAAGCGCACGTCAAACTTCCTGCTGTGGCAGTCTGCCTACGCGGAAATGGTCTACC
AAGACAAGCTGTTCCCTGATTTCACGCAGCAAGATCTGTACGACGCGGTCCTGGAATACGCCAAGCGGGATCGCAGATTC
GGAAGCGCATAA

Upstream 100 bases:

>100_bases
GGCTTTAAGGCCGAGGTGCCTGGCTGAACTGCAGCCCCTCCAGACCCTGAGATCAGGCTAAATGGCAAACACAAATAGTT
TGCATGGCAGAATAGCTTAG

Downstream 100 bases:

>100_bases
TGCCCACCAACCAGCCGACGCCAGCCCAAATCAAACGCTGGCGCGGATACCTGGCCAATGAGCAAGCAGAGGCCGCAGCC
TACCGCGACCTGGCCAAACG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVPYLSAYAFSTENWRRSTDEVR
FLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRELETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAA
EGKLRPEQITEKTFPNFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
GSA

Sequences:

>Translated_243_residues
MSEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVPYLSAYAFSTENWRRSTDEVR
FLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRELETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAA
EGKLRPEQITEKTFPNFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
GSA
>Mature_242_residues
SEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVPYLSAYAFSTENWRRSTDEVRF
LMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRELETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAAE
GKLRPEQITEKTFPNFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRFG
SA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=35.5263157894737, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI45580742, Length=228, Percent_Identity=35.5263157894737, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=40, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=32.1739130434783, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=34.2592592592593, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=230, Percent_Identity=30.4347826086957, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=32.7510917030568, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS2_CORGL (Q8NNC1)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927154
- RefSeq:   NP_601483.1
- RefSeq:   YP_226526.1
- ProteinModelPortal:   Q8NNC1
- SMR:   Q8NNC1
- GeneID:   1020236
- GeneID:   3344555
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2508
- KEGG:   cgl:NCgl2203
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q8NNC1
- ProtClustDB:   PRK14829
- BioCyc:   CGLU196627:CG2508-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28226; Mature: 28095

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 23-23

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVP
CCCCCCCCCCHHHCHHHEEEEECCCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCH
YLSAYAFSTENWRRSTDEVRFLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRE
HHHHHHHCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
LETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAAEGKLRPEQITEKTFPNFLDE
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHCCC
PDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
CCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
GSA
CCC
>Mature Secondary Structure 
SEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVP
CCCCCCCCCHHHCHHHEEEEECCCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCH
YLSAYAFSTENWRRSTDEVRFLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRE
HHHHHHHCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
LETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAAEGKLRPEQITEKTFPNFLDE
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHCCC
PDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
CCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
GSA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626