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The map label for this gene is dxr [H]

Identifier: 62390855

GI number: 62390855

Start: 2099950

End: 2101128

Strand: Reverse

Name: dxr [H]

Synonym: cg2208

Alternate gene names: 62390855

Gene position: 2101128-2099950 (Counterclockwise)

Preceding gene: 62390857

Following gene: 62390854

Centisome position: 64.01

GC content: 56.66

Gene sequence:

>1179_bases
ATGGGAGTCGTGACTAAAAAGATCCTTATTTTGGGAAGCACTGGTTCGATTGGAACTCAGGCGCTGGACGTTATTGCTGA
TAATTCAGACAAGTTTGAGGTGGTGGGTATCGCTGCGGGCGGTTCTCAGCCAGACCTCGTTATTTCGCAGGCGCAGCAGT
TGGGGCTGGCTGCAGACAAGGTTGCGGTTGCTGATGCACAGGCTGCCGCAGTAATTTCGAAGGCTCTCGGCGGCGAGATC
ATCTCTGGAACCGATGCTGCGAAGATTCTGGTGGAAACCACAAAGGCCGACACTGTGCTTAATGCTCTGGTTGGTTCTTT
GGGGCTTGCGGCAACGCTGGCCACTCTGGAATCTGGTGCGCATCTTGCCTTGGCTAACAAAGAATCGCTGGTTGCCGGTG
GTGAGTTTGTTACCTCAAAGGCAAAGCTGGGGCAGATCATTCCGGTCGATTCGGAGCACTCTGCCATGGCGCAGTGTTTG
CGTTCGGGTACTCGTGATGAGGTTGCGCGGATTGTGCTGACAGCTTCGGGCGGACCTTTCAGGGGCTGGACCAGGGAGAA
GATGTGGGAGGTGACTCCCGAGCAGGCAGCAGCGCACCCAACGTGGGCGATGGGGCAGATGAACACGTTGAACTCCGCCA
CCCTTATTAATAAAGGCCTCGAACTCATCGAGGCGACCCTGCTGTTTGAAACGGATGCGGATCTCATTGATGTGACGGTG
CATCCGCAGTCGATCATCCACTCCATGATCACGTTTACGGATGGTGCGACCATCGCGCAGGCGTCGCCACCATCGATGAA
ACTGCCGATCGCGTTGGCGCTTGATTGGCCACATCGGGTGCCGAAGGCTCAGCCGGCGCTGGATTTCACCGCTGCTCATA
CCTGGGCTTTTGAGCCGGTGGATGATGCCGCATTCCCTGCGGTGCAGCTGGCTAGGCACGTCGCAAAGCAAAAAGGCACG
TACCCCGCGGTGTATAACGCCGCCAACGAGGAGGCGGCTGAGGCGTTTTTGCGCGGGCGAATCAAGTTTCCGCAGATCGT
GGACGTGGTGGACGAGGTCCTCCAAGGAGCTTCTCAGTTTGCTGGTGTAGCATCACACGTCGATGATATTTTGGCAACCG
AATCTGAGGCACGCGCGCGTGCGAATGCTTTGATCAACCGGTTGGCAACCAACTTGTAA

Upstream 100 bases:

>100_bases
ACTGCGCTTTCGCAGTCATCATGCAGGCATAACCTGAAACCCATCCGTTTGGATTGCCCCAAATGGGTGTAGTGGGTGCG
TTTACCCAACAAGTGCAAGA

Downstream 100 bases:

>100_bases
GCTAAGGAGCTTCCGCCTCGTGGCAGCCTATCTTCTTGGTGTCGTATTATTTTTCCTCGGCATCGCAGTAACCATCGCGC
TTCACGAGTGGGGGCACTTC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MGVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADKVAVADAQAAAVISKALGGEI
ISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGAHLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCL
RSGTRDEVARIVLTASGGPFRGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWAFEPVDDAAFPAVQLARHVAKQKGT
YPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQFAGVASHVDDILATESEARARANALINRLATNL

Sequences:

>Translated_392_residues
MGVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADKVAVADAQAAAVISKALGGEI
ISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGAHLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCL
RSGTRDEVARIVLTASGGPFRGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWAFEPVDDAAFPAVQLARHVAKQKGT
YPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQFAGVASHVDDILATESEARARANALINRLATNL
>Mature_391_residues
GVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADKVAVADAQAAAVISKALGGEII
SGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGAHLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCLR
SGTRDEVARIVLTASGGPFRGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTVH
PQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWAFEPVDDAAFPAVQLARHVAKQKGTY
PAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQFAGVASHVDDILATESEARARANALINRLATNL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=403, Percent_Identity=37.2208436724566, Blast_Score=235, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40958; Mature: 40827

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADK
CCCCEEEEEEEECCCCCCHHHHHEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHH
VAVADAQAAAVISKALGGEIISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGA
HHHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
HLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCLRSGTRDEVARIVLTASGGPF
EEEEECCCCEEECCHHHCCHHHCCCEECCCCCHHHHHHHHHCCCHHHEEEEEEEECCCCC
RGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
CCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEEE
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWAFEPV
CHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEECCCCCCCCCCCCCEEECCCEEECCCC
DDAAFPAVQLARHVAKQKGTYPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQF
CCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AGVASHVDDILATESEARARANALINRLATNL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVVTKKILILGSTGSIGTQALDVIADNSDKFEVVGIAAGGSQPDLVISQAQQLGLAADK
CCCEEEEEEEECCCCCCHHHHHEEECCCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHH
VAVADAQAAAVISKALGGEIISGTDAAKILVETTKADTVLNALVGSLGLAATLATLESGA
HHHHHHHHHHHHHHHHCCCEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
HLALANKESLVAGGEFVTSKAKLGQIIPVDSEHSAMAQCLRSGTRDEVARIVLTASGGPF
EEEEECCCCEEECCHHHCCHHHCCCEECCCCCHHHHHHHHHCCCHHHEEEEEEEECCCCC
RGWTREKMWEVTPEQAAAHPTWAMGQMNTLNSATLINKGLELIEATLLFETDADLIDVTV
CCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEEE
HPQSIIHSMITFTDGATIAQASPPSMKLPIALALDWPHRVPKAQPALDFTAAHTWAFEPV
CHHHHHHHHHHHCCCCEEECCCCCCEECCEEEEECCCCCCCCCCCCCEEECCCEEECCCC
DDAAFPAVQLARHVAKQKGTYPAVYNAANEEAAEAFLRGRIKFPQIVDVVDEVLQGASQF
CCHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AGVASHVDDILATESEARARANALINRLATNL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA