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The map label for this gene is thyX

Identifier: 62390812

GI number: 62390812

Start: 2050434

End: 2051186

Strand: Reverse

Name: thyX

Synonym: cg2162

Alternate gene names: 62390812

Gene position: 2051186-2050434 (Counterclockwise)

Preceding gene: 62390813

Following gene: 62390811

Centisome position: 62.48

GC content: 51.13

Gene sequence:

>753_bases
GTGGCCGAACAAGTTAAATTGAGCGTGGAGTTGATAGCGTGCAGTTCTTTTACTCCACCCGCTGATGTTGAGTGGTCAAC
TGATGTTGAGGGCGCGGAAGCACTCGTCGAGTTTGCGGGTCGTGCCTGCTACGAAACTTTTGATAAGCCGAACCCTCGAA
CTGCTTCCAATGCTGCGTATCTGCGCCACATCATGGAAGTGGGGCACACTGCTTTGCTTGAGCATGCCAATGCCACGATG
TATATCCGAGGCATTTCTCGGTCCGCGACCCATGAATTGGTCCGACACCGCCATTTTTCCTTCTCTCAACTGTCTCAGCG
TTTCGTGCACAGCGGAGAATCGGAAGTAGTGGTGCCCACTCTCATCGATGAAGATCCGCAGTTGCGTGAACTTTTCATGC
ACGCCATGGATGAGTCTCGGTTCGCTTTCAATGAGCTGCTTAATGCGCTGGAAGAAAAACTTGGCGATGAACCGAATGCA
CTTTTAAGGAAAAAGCAGGCTCGTCAAGCAGCTCGCGCTGTGCTGCCCAACGCTACAGAGTCCAGAATCGTGGTGTCTGG
AAACTTCCGCACCTGGAGGCATTTCATTGGCATGCGAGCCAGTGAACATGCAGACGTCGAAATCCGCGAAGTAGCGGTAG
AATGTTTAAGAAAGCTGCAGGTAGCAGCGCCAACTGTTTTCGGTGATTTTGAGATTGAAACTTTGGCAGACGGATCGCAA
ATGGCAACAAGCCCGTATGTCATGGACTTTTAA

Upstream 100 bases:

>100_bases
ACAGCACCCAGGCCTAGTCGTAGGACTTGAGCATTACCTAGGCCTGTAAAGGCTCATTTCAGCAGCGGGTGGAATTTTTT
AAAAGGAGCGTTTAAAGGCT

Downstream 100 bases:

>100_bases
CGCAAAGCTCACACCCACGAGCTAAAAATTCATATAGTTAAGACAACATTTTTGGCTGTAAAAGACAGCCGTAAAAACCT
CTTGCTCGTGTCAATTGTTC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATM
YIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNA
LLRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQ
MATSPYVMDF

Sequences:

>Translated_250_residues
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATM
YIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNA
LLRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQ
MATSPYVMDF
>Mature_249_residues
AEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATMY
IRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNAL
LRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQM
ATSPYVMDF

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_CORGL (P40111)

Other databases:

- EMBL:   Z21502
- EMBL:   BA000036
- EMBL:   BX927153
- PIR:   B40626
- RefSeq:   NP_601178.1
- RefSeq:   YP_226214.1
- PDB:   3FNN
- PDB:   3GE9
- PDBsum:   3FNN
- PDBsum:   3GE9
- ProteinModelPortal:   P40111
- SMR:   P40111
- GeneID:   1019929
- GeneID:   3342737
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2162
- KEGG:   cgl:NCgl1897
- HOGENOM:   HBG458114
- OMA:   RATEHAD
- ProtClustDB:   PRK00847
- BioCyc:   CGLU196627:CG2162-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 28065; Mature: 27934

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAY
CCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LRHIMEVGHTALLEHANATMYIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPT
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
LIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNALLRKKQARQAARAVLPNATE
ECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
SRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQ
CEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCH
MATSPYVMDF
HCCCCCEECC
>Mature Secondary Structure 
AEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAY
CCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LRHIMEVGHTALLEHANATMYIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPT
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
LIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNALLRKKQARQAARAVLPNATE
ECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
SRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQ
CEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCH
MATSPYVMDF
HCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478336; 12948626