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The map label for this gene is dapA

Identifier: 62390811

GI number: 62390811

Start: 2049328

End: 2050233

Strand: Reverse

Name: dapA

Synonym: cg2161

Alternate gene names: 62390811

Gene position: 2050233-2049328 (Counterclockwise)

Preceding gene: 62390812

Following gene: 62390810

Centisome position: 62.46

GC content: 52.65

Gene sequence:

>906_bases
ATGAGCACAGGTTTAACAGCTAAGACCGGAGTAGAGCACTTCGGCACCGTTGGAGTAGCAATGGTTACTCCATTCACGGA
ATCCGGAGACATCGATATCGCTGCTGGCCGCGAAGTCGCGGCTTATTTGGTTGATAAGGGCTTGGATTCTTTGGTTCTCG
CGGGCACCACTGGTGAATCCCCAACGACAACCGCCGCTGAAAAACTAGAACTGCTCAAGGCCGTTCGTGAGGAAGTTGGG
GATCGGGCGAAGCTCATCGCCGGTGTCGGAACCAACAACACGCGGACATCTGTGGAACTTGCGGAAGCTGCTGCTTCTGC
TGGCGCAGACGGCCTTTTAGTTGTAACTCCTTATTACTCCAAGCCGAGCCAAGAGGGATTGCTGGCGCACTTCGGTGCAA
TTGCTGCAGCAACAGAGGTTCCAATTTGTCTCTATGACATTCCTGGTCGGTCAGGTATTCCAATTGAGTCTGATACCATG
AGACGCCTGAGTGAATTACCTACGATTTTGGCGGTCAAGGACGCCAAGGGTGACCTCGTTGCAGCCACGTCATTGATCAA
AGAAACGGGACTTGCCTGGTATTCAGGCGATGACCCACTAAACCTTGTTTGGCTTGCTTTGGGCGGATCAGGTTTCATTT
CCGTAATTGGACATGCAGCCCCCACAGCATTACGTGAGTTGTACACAAGCTTCGAGGAAGGCGACCTCGTCCGTGCGCGG
GAAATCAACGCCAAACTATCACCGCTGGTAGCTGCCCAAGGTCGCTTGGGTGGAGTCAGCTTGGCAAAAGCTGCTCTGCG
TCTGCAGGGCATCAACGTAGGAGATCCTCGACTTCCAATTATGGCTCCAAATGAGCAGGAACTTGAGGCTCTCCGAGAAG
ACATGAAAAAAGCTGGAGTTCTATAA

Upstream 100 bases:

>100_bases
TTATCGGAATGTGGCTTGGGCGATTGTTATGCAAAAGTTGTTAGGTTTTTTGCGGGGTTGTTTAACCCCCAAATGAGGGA
AGAAGGTAACCTTGAACTCT

Downstream 100 bases:

>100_bases
ATATGAATGATTCCCGAAATCGCGGCCGGAAGGTTACCCGCAAGGCGGGCCCACCAGAAGCTGGTCAGGAAAACCATCTG
GATACCCCTGTCTTTCAGGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSTGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGREVAAYLVDKGLDSLVLAGTTGESPTTTAAEKLELLKAVREEVG
DRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYSKPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTM
RRLSELPTILAVKDAKGDLVAATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNEQELEALREDMKKAGVL

Sequences:

>Translated_301_residues
MSTGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGREVAAYLVDKGLDSLVLAGTTGESPTTTAAEKLELLKAVREEVG
DRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYSKPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTM
RRLSELPTILAVKDAKGDLVAATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNEQELEALREDMKKAGVL
>Mature_300_residues
STGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGREVAAYLVDKGLDSLVLAGTTGESPTTTAAEKLELLKAVREEVGD
RAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYSKPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTMR
RLSELPTILAVKDAKGDLVAATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRARE
INAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNEQELEALREDMKKAGVL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=286, Percent_Identity=27.6223776223776, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI13540533, Length=293, Percent_Identity=27.3037542662116, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788823, Length=287, Percent_Identity=34.8432055749129, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI87082415, Length=284, Percent_Identity=31.6901408450704, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789620, Length=236, Percent_Identity=30.0847457627119, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786463, Length=275, Percent_Identity=27.6363636363636, Blast_Score=98, Evalue=7e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CORGL (P19808)

Other databases:

- EMBL:   X53993
- EMBL:   Z21502
- EMBL:   BA000036
- EMBL:   BX927153
- PIR:   C40626
- RefSeq:   NP_601177.1
- RefSeq:   YP_226213.1
- PDB:   3CPR
- PDBsum:   3CPR
- ProteinModelPortal:   P19808
- SMR:   P19808
- World-2DPAGE:   0001:P19808
- PRIDE:   P19808
- GeneID:   1019928
- GeneID:   3345490
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2161
- KEGG:   cgl:NCgl1896
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   P19808
- ProtClustDB:   PRK03170
- BioCyc:   CGLU196627:CG2161-MONOMER
- BioCyc:   MetaCyc:MONOMER-6444
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31262; Mature: 31131

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 173-173 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGREVAAYLVDKGLDSLVLAGTTGES
CCCCCCCHHCHHHHCCCCEEEEECCCCCCCEEEECCCHHHHHHHHCCCCCEEEECCCCCC
PTTTAAEKLELLKAVREEVGDRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYS
CCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
KPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTMRRLSELPTILAVKDAKGDLV
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHH
AATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
HHHHHHHHHCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNEQELEALREDMKKAGV
HCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure 
STGLTAKTGVEHFGTVGVAMVTPFTESGDIDIAAGREVAAYLVDKGLDSLVLAGTTGES
CCCCCCHHCHHHHCCCCEEEEECCCCCCCEEEECCCHHHHHHHHCCCCCEEEECCCCCC
PTTTAAEKLELLKAVREEVGDRAKLIAGVGTNNTRTSVELAEAAASAGADGLLVVTPYYS
CCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
KPSQEGLLAHFGAIAAATEVPICLYDIPGRSGIPIESDTMRRLSELPTILAVKDAKGDLV
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHH
AATSLIKETGLAWYSGDDPLNLVWLALGGSGFISVIGHAAPTALRELYTSFEEGDLVRAR
HHHHHHHHHCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
EINAKLSPLVAAQGRLGGVSLAKAALRLQGINVGDPRLPIMAPNEQELEALREDMKKAGV
HCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2129555; 8478336; 12948626