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The map label for this gene is dxs

Identifier: 62390741

GI number: 62390741

Start: 1973447

End: 1975357

Strand: Reverse

Name: dxs

Synonym: cg2083

Alternate gene names: 62390741

Gene position: 1975357-1973447 (Counterclockwise)

Preceding gene: 62390742

Following gene: 62390738

Centisome position: 60.17

GC content: 53.01

Gene sequence:

>1911_bases
ATGGGAATTCTGAACAGTATTTCAACACCTGCTGACTTAAAGGCCCTTAATGATGAGGATTTGGACGCTCTTGCCAAAGA
AATCCGAACTTTCCTGGTCGATAAAGTCGCAGCAACTGGTGGCCACTTAGGTCCAAATTTGGGCGTAGTGGAATTAACCA
TCGGTCTTCATCGAGTTTTCGATTCGCCTCAAGACCCGATCATCTTTGATACTTCTCACCAGTCCTATGTGCATAAGATC
CTGACGGGTCGCGCTAAAGATTTTGATTCTTTGCGTCAAAAAGATGGCCTTTCTGGTTACACCTGCCGTGCTGAAAGTGA
GCACGATTGGACTGAGTCTTCGCATGCTTCGGCGGCCTTGTCTTATGCGGATGGTTTGTCTAAAGCCAAGCAGTTGGATG
GCGATACCACGCATAGTGTGGTTGCTGTCGTTGGTGATGGCGCTCTAACTGGCGGCATGTGTTGGGAAGCACTGAACAAT
ATTGCTGCTGGTAAAGACCGCAAAGTTGTTGTCGTAGTCAATGACAATGGCCGGAGTTATTCTCCAACCATTGGCGGATT
TGCGGAAAACCTTGCGGGCCTTCGCATGCAGCCTTTCTATGATCGCTTCATGGAAAAGGGCAAGACGTCCCTGAAATCCA
TGGGGTGGGTAGGGGAGCGTACTTTTGAAGCGCTCCATGCATTTAAAGAAGGTGTGAAGAGCACCGTCATTCCCACCGAA
ATGTTCCCTGAACTGGGCATGAAATACGTGGGTCCGGTTGATGGACATAACCAAAAAGCTGTCGACAATGCGCTGAAATA
CGCTCATGATTATGATGGCCCCATCATCGTGCACATGGTCACCGAAAAGGGTCGTGGTTACGCGCCTGCTGAGCAGGATT
TGGACGAATTGATGCACTCCACGGGCGTCATCGATCCGCTCACAGGAGCTCCTAAATCTGCATCAAAGCCCGGTTGGACC
TCTGTGTTCAGCGATGAGCTGGTCAAGATTGGTGCGCAGAATGAAAACGTTGTTGCCATCACCGCCGCGATGGCAGGTCC
TACCGGTCTGTCCAAGTTCGAAGCCAATTTCCCCAACCGATTCTTTGATGTCGGCATTGCTGAGCAGCACGCGGTAACTT
CTGCCGCAGGCCTCGCATTGGGTGGAAAACACCCTGTGGTGGCTATTTACTCCACGTTCTTGAACCGCGCTTTTGATCAG
CTGCTCATGGATGTGGGCATGCTCAACCAGCCTGTTACTTTGGTGCTTGATCGCTCAGGTGTCACGGGTTCGGATGGAGC
GAGCCACAATGGCGTCTGGGATATGGCGCTGACCTCGATCGTTCCAGGCGTGCAGGTGGCGGCACCACGTGATGAGGATT
CCTTGCGTGAGCTGCTCAATGAGGCTATTTCCATCGATGATGGCCCCACAGTTGTGCGTTTCCCCAAGGGCGACTTGCCA
ACTCCAATTGTTGCTATCGACACCTTGGAAGACGGCGTGGATGTCCTCGCATATGAAGACGCCACTGACGTTGAATCAAC
CGACGATGCGCCATCAGTTCTCATCATTGCGGTAGGCGAGCGCGCAACTGTTGCACTTGACGTTGCTTCCAGGATTAAAC
AGCACGGCGTGAACGTCACGGTTGTTGACCCCCGCTGGATTGTCCCCATCCCGCAGTCCTTGGTCGCGCTGTCTGATGAT
CATGACCTCGTGATCACCATCGAAGACGGCGTCATCCACGGCGGCGTGGGATCCTTGCTCTCTGATGCGCTTAACGCCTC
TGAGGTGGATACCCCTCGCCGACAAATCGCCGTGCCCCAGAAGTACCTGGATCACGCGTCCCGCAATGAAGTGCTCGCCG
ATTATGGCCTCGACGCCGACGGCATTGAAACCACTGTTGTTGGATGGCTGGATTCCCTGTTCGGGGAATAA

Upstream 100 bases:

>100_bases
GCAGGTGCACATTTGTTTTGTCACCTGCACAAAAGTGTCGCCAGCCCGATACTTGTACAACCGTCCGCATCCGAGAAGCA
AAGGTGTCTGACTCGCGCCA

Downstream 100 bases:

>100_bases
AACCCTGCTTATCGACGCCGCCCTCCACCGAAGCCCGCAGCCTTAGCCGCGGGCTTTAGGTTTAGAGCTTCAGCAAGTTG
GCGGACAGAATCGGAAAAGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MGILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVFDSPQDPIIFDTSHQSYVHKI
LTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAALSYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNN
IAAGKDRKVVVVVNDNGRSYSPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHSTGVIDPLTGAPKSASKPGWT
SVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNRFFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQ
LLMDVGMLNQPVTLVLDRSGVTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
TPIVAIDTLEDGVDVLAYEDATDVESTDDAPSVLIIAVGERATVALDVASRIKQHGVNVTVVDPRWIVPIPQSLVALSDD
HDLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLDHASRNEVLADYGLDADGIETTVVGWLDSLFGE

Sequences:

>Translated_636_residues
MGILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVFDSPQDPIIFDTSHQSYVHKI
LTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAALSYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNN
IAAGKDRKVVVVVNDNGRSYSPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHSTGVIDPLTGAPKSASKPGWT
SVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNRFFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQ
LLMDVGMLNQPVTLVLDRSGVTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
TPIVAIDTLEDGVDVLAYEDATDVESTDDAPSVLIIAVGERATVALDVASRIKQHGVNVTVVDPRWIVPIPQSLVALSDD
HDLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLDHASRNEVLADYGLDADGIETTVVGWLDSLFGE
>Mature_635_residues
GILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVFDSPQDPIIFDTSHQSYVHKIL
TGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAALSYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNNI
AAGKDRKVVVVVNDNGRSYSPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTEM
FPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHSTGVIDPLTGAPKSASKPGWTS
VFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNRFFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQL
LMDVGMLNQPVTLVLDRSGVTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLPT
PIVAIDTLEDGVDVLAYEDATDVESTDDAPSVLIIAVGERATVALDVASRIKQHGVNVTVVDPRWIVPIPQSLVALSDDH
DLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLDHASRNEVLADYGLDADGIETTVVGWLDSLFGE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=525, Percent_Identity=23.2380952380952, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4507521, Length=525, Percent_Identity=23.2380952380952, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI133778974, Length=304, Percent_Identity=28.2894736842105, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI225637459, Length=311, Percent_Identity=25.08038585209, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637463, Length=311, Percent_Identity=25.08038585209, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637461, Length=311, Percent_Identity=25.08038585209, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786622, Length=632, Percent_Identity=36.5506329113924, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539652, Length=483, Percent_Identity=24.4306418219462, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645119, Length=473, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551847, Length=473, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550715, Length=473, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666278, Length=483, Percent_Identity=24.8447204968944, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CORGL (Q8NPB2)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927153
- RefSeq:   NP_601108.1
- RefSeq:   YP_226143.1
- ProteinModelPortal:   Q8NPB2
- SMR:   Q8NPB2
- GeneID:   1019859
- GeneID:   3345212
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2083
- KEGG:   cgl:NCgl1827
- HOGENOM:   HBG571647
- OMA:   RESILRY
- ProtClustDB:   PRK05444
- BioCyc:   CGLU196627:CG2083-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67881; Mature: 67750

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVF
CCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHH
DSPQDPIIFDTSHQSYVHKILTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAAL
CCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHH
SYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNNIAAGKDRKVVVVVNDNGRSY
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
SPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHS
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
TGVIDPLTGAPKSASKPGWTSVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCCCHHHHCCCCCH
FFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQLLMDVGMLNQPVTLVLDRSG
HEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
VTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCC
TPIVAIDTLEDGVDVLAYEDATDVESTDDAPSVLIIAVGERATVALDVASRIKQHGVNVT
CCEEEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHCCCEEE
VVDPRWIVPIPQSLVALSDDHDLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQ
EECCEEEECCCHHHEEECCCCCEEEEEECCEEECCHHHHHHHHCCCCCCCCCHHHHCCCH
KYLDHASRNEVLADYGLDADGIETTVVGWLDSLFGE
HHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVF
CCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHH
DSPQDPIIFDTSHQSYVHKILTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAAL
CCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHH
SYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNNIAAGKDRKVVVVVNDNGRSY
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
SPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHS
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
TGVIDPLTGAPKSASKPGWTSVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCCCHHHHCCCCCH
FFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQLLMDVGMLNQPVTLVLDRSG
HEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
VTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCC
TPIVAIDTLEDGVDVLAYEDATDVESTDDAPSVLIIAVGERATVALDVASRIKQHGVNVT
CCEEEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHCCCEEE
VVDPRWIVPIPQSLVALSDDHDLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQ
EECCEEEECCCHHHEEECCCCCEEEEEECCEEECCHHHHHHHHCCCCCCCCCHHHHCCCH
KYLDHASRNEVLADYGLDADGIETTVVGWLDSLFGE
HHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626