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The map label for this gene is thrS [H]

Identifier: 62390552

GI number: 62390552

Start: 1771796

End: 1773898

Strand: Reverse

Name: thrS [H]

Synonym: cg1880

Alternate gene names: 62390552

Gene position: 1773898-1771796 (Counterclockwise)

Preceding gene: 62390553

Following gene: 62390551

Centisome position: 54.04

GC content: 55.3

Gene sequence:

>2103_bases
ATGCCGTTTGCCCACGTGAGCGCACGAAGGAGCGCAATTTTCGTGAACACCACAGATACCGCAGTAGCAAACCTTGTTGT
TTTTGAGGTCCCTGCAGGCACCGCAATTGGTGCAGCAATGCGCGAACTAGATCTGCCCAACAAGGGTCCAGAGGCTATCG
TTTGTGCAAAAGACGCTGAAGGCCAACTAAAGGATCTTTCACACGTCCCAGAAACCACTGCTACGTTCACCGCTGTACCT
GCAAATACTGATGACGGCCGCGCAGTAATCCGCCACTCGTGCGCTCACGTGCTGGCACAGGCTGTCCAGGCAGAATTCCC
AGGAACCAAGTTGGGCATCGGCCCAGCCATTGAAAATGGTTTCTACTACGACTTCGATGCGGCTGAGCCTTTCACTCCGG
AAGATCTCAAGACCATTGAAAAGCGGATGAAGAAGATCATCAAGACCGGCCAGAAGTTTGAGCGCCGCGTCTATGAATCC
GCTGAAGCTGCAGCGGAAGAGTTGAAGAACGAGCCTTACAAGCTGGAACTTATCCAGGACAAGGGCAACGTTGATCCCAA
CTCTGATGAAGCCACCGAAGTGGGCGCAGGCGAACTGACCGCGTATGACAACGTCAACCCTCGCACCAGTGAGGTGGAGT
GGTCTGATCTTTGCCGTGGACCACACATCCCAACCACCCGCTACATTCCAGCATTCGCATTGACCCGATCATCCGCTGCT
TATTGGCGTGGCGATCAGGATAATGCTGGCCTGCAGCGCATCTACGGTACCGCGTGGGAGGATAAGGAATCCCTCGATGC
TTACCAGACCATGCTCGCTGAGGCAGAAAAGCGCGATCACCGCCGTCTAGGCACTGAACTTGATTTGTTCTCCTTCCCAG
ATGATCTGGGCTCTGGTCTGCCAGTATTCCATCCCAACGGTGGCATCGTGCGCAATGAGATGGAAGATCACTCCCGTCGC
CGCCACATCGCAGCGGGCTACTCCTTTGTGAACACCCCGCACATCACCAAGCAGGATCTCTTTGAGCGTTCCGGTCACCT
TGGTTTCTACAAGGATGGCATGTTCCCTCCAATGCAGGTGGATGCGGAGTTCGACGAAGACGGCAATGTGACCAAGCCGG
GCCAAGAGTACTACCTCAAGCCCATGAACTGCCCAATGCACAACCTCATCTTCGATTCTCGTGGACGTTCTTACCGTGAG
CTTCCACTGCGTCTTTTTGAGTTCGGCAACGTCTACCGCTACGAAAAGTCCGGTGTGATCCACGGCCTGACCCGTGCCCG
TGGCTTCACCCAGGACGATGCTCACATCTACTGCACCGAGGATCAGCTGGAAGCAGAGCTCACCTCTGTGCTGGACTTCA
TCCTGTCGCTGCTGCGCGATTACGGTTTGGATGATTTCTACCTGGAGCTCTCCACCCGCGATCCTAAGAAGTCAGTCGGT
TCTGATGAGATCTGGGAGCGTTCCACTGAAATCTTGAACCGTGTGGCCACCAATTCTGGCCTGGAACTTGTTCCAGACCC
AGAAGGTGCCGCATTCTACGGCCCTAAGATTTCTGTTCAGGCACGCGACGCGATTGGCCGTACCTGGCAGATGTCCACCG
TGCAGCTGGACTTCAACATGCCTGAGCGCTTCAACTTGGAATACACCTCATCTGATGGTTCCAAGCAGCAGCCCATCATG
ATCCACCGCGCACTGTTTGGTTCCATCGAGCGCTTCTTTGGCGTGTTGTTGGAGCACTACGCTGGTGCTTTCCCAGCATG
GCTGGCACCTCACCAGGTCATGGGTATTCCAGTTGCTGATGATTGCATTCCACACCTGGAGACAATCACCGCACAGCTGC
GTGAAAAGGGTATCCGCGCAGACGTGGACACCTCCGATGATCGCATGCAGAAGAAGATCCGCAACCACACCACCGGCAAG
GTTCCATTCATGCTGCTTGCCGGTGCCCGCGATGTGGAAGCAAACGCAGTGAGCTTCCGTTTCTTGGACGGCACCCAGGT
CAACGGCGTGCCCGTCGATGAGGCAATCGCTGTGATTTCTTCCTGGATTGGTGACCGCATCAATGATCAGCCGAGCGAGG
ACTCCATTGCAGCTCGCAGGTAG

Upstream 100 bases:

>100_bases
TGCCTAATATATCTGCGGTGAATCCCGATATTTCCCTCTTTTGGACGTATCGGGAGCGCCAGGTCAGCTGCGCACCTTGA
ACTAGTGGGGGCGGCCAGGT

Downstream 100 bases:

>100_bases
CCCTGAGATGGACTCATCTGACAGCCACGTTGGTCAGGATGTATATGTTGATCAAGGTCTAGGGGAGCCCGACAGACTGG
AACGTCTGTGGGCGCCCTAC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 700; Mature: 699

Protein sequence:

>700_residues
MPFAHVSARRSAIFVNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPETTATFTAVP
ANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDAAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYES
AEAAAEELKNEPYKLELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAA
YWRGDQDNAGLQRIYGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRR
RHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRE
LPLRLFEFGNVYRYEKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVG
SDEIWERSTEILNRVATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIM
IHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGK
VPFMLLAGARDVEANAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR

Sequences:

>Translated_700_residues
MPFAHVSARRSAIFVNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPETTATFTAVP
ANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDAAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYES
AEAAAEELKNEPYKLELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAA
YWRGDQDNAGLQRIYGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRR
RHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRE
LPLRLFEFGNVYRYEKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVG
SDEIWERSTEILNRVATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIM
IHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGK
VPFMLLAGARDVEANAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR
>Mature_699_residues
PFAHVSARRSAIFVNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPETTATFTAVPA
NTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDAAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESA
EAAAEELKNEPYKLELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAY
WRGDQDNAGLQRIYGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRRR
HIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYREL
PLRLFEFGNVYRYEKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGS
DEIWERSTEILNRVATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIMI
HRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKV
PFMLLAGARDVEANAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=675, Percent_Identity=35.4074074074074, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38202255, Length=608, Percent_Identity=36.8421052631579, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI20070344, Length=628, Percent_Identity=35.828025477707, Blast_Score=345, Evalue=1e-94,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=38.0503144654088, Blast_Score=468, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984184, Length=650, Percent_Identity=35.0769230769231, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71984192, Length=650, Percent_Identity=35.0769230769231, Blast_Score=385, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322112, Length=667, Percent_Identity=36.1319340329835, Blast_Score=398, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=33.75, Blast_Score=239, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24583842, Length=623, Percent_Identity=35.7945425361156, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28574141, Length=623, Percent_Identity=35.7945425361156, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583839, Length=623, Percent_Identity=35.7945425361156, Blast_Score=391, Evalue=1e-109,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 78173; Mature: 78042

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFAHVSARRSAIFVNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAE
CCCCCCCCCCCEEEEECCCHHEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GQLKDLSHVPETTATFTAVPANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENG
CHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCC
FYYDFDAAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYKLELIQD
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
KGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAA
CCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHEECCCCC
YWRGDQDNAGLQRIYGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGL
EECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCC
PVFHPNGGIVRNEMEDHSRRRHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQV
CEECCCCCEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEECCCCCCCEEE
DAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRYEKSGVI
CCCCCCCCCCCCCCHHHEECCCCCCHHHHEECCCCCCHHHHHHHHHHCCCEEEEECCCCH
HGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVG
HHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHCCC
SDEIWERSTEILNRVATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNM
CHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCEEEEEEHHHCCCEEEEEEEEEECCC
PERFNLEYTSSDGSKQQPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVAD
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCEECCCCHH
DCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFR
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEE
FLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PFAHVSARRSAIFVNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAE
CCCCCCCCCCEEEEECCCHHEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GQLKDLSHVPETTATFTAVPANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENG
CHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCC
FYYDFDAAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYKLELIQD
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
KGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAA
CCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHEECCCCC
YWRGDQDNAGLQRIYGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGL
EECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCC
PVFHPNGGIVRNEMEDHSRRRHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQV
CEECCCCCEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEECCCCCCCEEE
DAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRYEKSGVI
CCCCCCCCCCCCCCHHHEECCCCCCHHHHEECCCCCCHHHHHHHHHHCCCEEEEECCCCH
HGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVG
HHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHCCC
SDEIWERSTEILNRVATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNM
CHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCEEEEEEHHHCCCEEEEEEEEEECCC
PERFNLEYTSSDGSKQQPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVAD
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCEECCCCHH
DCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFR
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEE
FLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]