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The map label for this gene is 62390551

Identifier: 62390551

GI number: 62390551

Start: 1771150

End: 1771788

Strand: Reverse

Name: 62390551

Synonym: cg1879

Alternate gene names: NA

Gene position: 1771788-1771150 (Counterclockwise)

Preceding gene: 62390552

Following gene: 62390550

Centisome position: 53.97

GC content: 53.68

Gene sequence:

>639_bases
ATGGACTCATCTGACAGCCACGTTGGTCAGGATGTATATGTTGATCAAGGTCTAGGGGAGCCCGACAGACTGGAACGTCT
GTGGGCGCCCTACCGGATGAGCTACATCAACACTCGATCTGGCGGTAAGCAATCAACTACCGCCAAGCGGGACCCCTTCA
TTGAGGTTCCCAAAATGAGTGATGAGGACGGCCTGATCGTTGCGCGGGGTGAGCTGGTGTATTGCGTACTCAACTTGTAT
CCCTACAACGCTGGACACATGATGGTGATCCCATTCCGTAAGGAAAAGAATCTAGAGGATTTGAGCTTGGCAGAATCTGC
GGAGTTGATGCTCTTTACCCAAACGGCCATCAAGGCGCTGAAGCAGGTGTCAAACCCTGATGCTGTCAATGTTGGTTTAA
ACCTTGGCAAAGCATCGGGTGGCTCAGTGGGAGATCACCTTCATGTCCATGTGGTGCCTAGGTGGTCGGGTGATGCTAAT
TTCATGACTGTGATTGACGGTGTCAAAGTGCTACCGCAGACCCTGCGTCAAACCAGGGCCATGCTTGCGCAAGCATGGGG
CACCATTGATGGGGCACCAGGCACTGTCGACCCAACGCTGACTTCAGCGATCCGTACCGCAGCACCGAAGGAGCACTGA

Upstream 100 bases:

>100_bases
CCCGTCGATGAGGCAATCGCTGTGATTTCTTCCTGGATTGGTGACCGCATCAATGATCAGCCGAGCGAGGACTCCATTGC
AGCTCGCAGGTAGCCCTGAG

Downstream 100 bases:

>100_bases
TGCTGGGACTTCATGGACGTAAGCCTGCGCAGGTTATTGTTGAGCCTGTTGCCAAATTGATGATCAAGTTGAAGGTGACG
CCTAATCAGCTCACCTTAGT

Product: HIT family hydrolase

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MDSSDSHVGQDVYVDQGLGEPDRLERLWAPYRMSYINTRSGGKQSTTAKRDPFIEVPKMSDEDGLIVARGELVYCVLNLY
PYNAGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKALKQVSNPDAVNVGLNLGKASGGSVGDHLHVHVVPRWSGDAN
FMTVIDGVKVLPQTLRQTRAMLAQAWGTIDGAPGTVDPTLTSAIRTAAPKEH

Sequences:

>Translated_212_residues
MDSSDSHVGQDVYVDQGLGEPDRLERLWAPYRMSYINTRSGGKQSTTAKRDPFIEVPKMSDEDGLIVARGELVYCVLNLY
PYNAGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKALKQVSNPDAVNVGLNLGKASGGSVGDHLHVHVVPRWSGDAN
FMTVIDGVKVLPQTLRQTRAMLAQAWGTIDGAPGTVDPTLTSAIRTAAPKEH
>Mature_212_residues
MDSSDSHVGQDVYVDQGLGEPDRLERLWAPYRMSYINTRSGGKQSTTAKRDPFIEVPKMSDEDGLIVARGELVYCVLNLY
PYNAGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKALKQVSNPDAVNVGLNLGKASGGSVGDHLHVHVVPRWSGDAN
FMTVIDGVKVLPQTLRQTRAMLAQAWGTIDGAPGTVDPTLTSAIRTAAPKEH

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 23133; Mature: 23133

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSDSHVGQDVYVDQGLGEPDRLERLWAPYRMSYINTRSGGKQSTTAKRDPFIEVPKMS
CCCCCCCCCCEEEEECCCCCHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCEEECCCCC
DEDGLIVARGELVYCVLNLYPYNAGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKAL
CCCCEEEECCCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHCCCCEEEEEHHHHHHHH
KQVSNPDAVNVGLNLGKASGGSVGDHLHVHVVPRWSGDANFMTVIDGVKVLPQTLRQTRA
HHCCCCCEEEECEEECCCCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHH
MLAQAWGTIDGAPGTVDPTLTSAIRTAAPKEH
HHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDSSDSHVGQDVYVDQGLGEPDRLERLWAPYRMSYINTRSGGKQSTTAKRDPFIEVPKMS
CCCCCCCCCCEEEEECCCCCHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCEEECCCCC
DEDGLIVARGELVYCVLNLYPYNAGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKAL
CCCCEEEECCCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHCCCCEEEEEHHHHHHHH
KQVSNPDAVNVGLNLGKASGGSVGDHLHVHVVPRWSGDANFMTVIDGVKVLPQTLRQTRA
HHCCCCCEEEECEEECCCCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHH
MLAQAWGTIDGAPGTVDPTLTSAIRTAAPKEH
HHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]