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The map label for this gene is apt [H]

Identifier: 62390536

GI number: 62390536

Start: 1756394

End: 1756951

Strand: Reverse

Name: apt [H]

Synonym: cg1862

Alternate gene names: 62390536

Gene position: 1756951-1756394 (Counterclockwise)

Preceding gene: 62390537

Following gene: 62390535

Centisome position: 53.52

GC content: 53.76

Gene sequence:

>558_bases
GTGAGCGAACAAGCTCTAAGCACCTTCGACAGGGCACGTGAGGCCCTGGACAAGAAAACCCGATATGTGCAGGATTTCCC
AGAAAAGGGTGTGCTTTTTGAAGACCTCACCCCGGTGTTGGGCGATGCAGAATCATTTGTGGCCGTGGTGGACGCCATGG
CTGAAGCTGCAGAAAAACTGAATGCAGAAATCATCGGTGGCTTGGATGCGCGAGGATTCCTCCTCGGATCTGCTGTCGCT
TACAAACTCGGCCTAGGTGTGCTGGCTATCCGCAAGAAGGGAAAGCTCCCCCCACCTGTGGTGACCCAGGAGTATGAACT
TGAATACGGCACTGCAGCACTCGAGCTGCCCAGTGAAGGAATCGACATTGCTGGTAAAAACATCGTTTTGATCGACGATG
TGCTGGCAACCGGCGGCACCTTGGGCGCTGCACGTAAACTAATTGAATCGTGTGACGGACATGTTTCCGGATATGTTCTT
GCCATTGAGGTCCCAGGCCTCGGCGGTAGGGATAATCTTGGTGATAGGCCCGTCATTGTGGTCAGAGATCCTCAGTAG

Upstream 100 bases:

>100_bases
GTTTGTGATAGATCGCACAGTCGGTAACGTTGTTGTTAATACAGACCTAGCCGGTATCGGATGGAACATGGACCGTTGGT
CCAGAAGTGAGGAATAAGTA

Downstream 100 bases:

>100_bases
AAGGATCGAAAGAAAGGCGGCAGGAAAATGAGTCTGGAGCGCAACACACAAAAATCTTCCATGGGTGTGCGAAGCATGTC
AGCCAGGCTTGCCCGCAGCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSEQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFVAVVDAMAEAAEKLNAEIIGGLDARGFLLGSAVA
YKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEGIDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVL
AIEVPGLGGRDNLGDRPVIVVRDPQ

Sequences:

>Translated_185_residues
MSEQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFVAVVDAMAEAAEKLNAEIIGGLDARGFLLGSAVA
YKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEGIDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVL
AIEVPGLGGRDNLGDRPVIVVRDPQ
>Mature_184_residues
SEQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFVAVVDAMAEAAEKLNAEIIGGLDARGFLLGSAVAY
KLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEGIDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVLA
IEVPGLGGRDNLGDRPVIVVRDPQ

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=173, Percent_Identity=39.3063583815029, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI71773201, Length=132, Percent_Identity=41.6666666666667, Blast_Score=107, Evalue=8e-24,
Organism=Escherichia coli, GI1786675, Length=160, Percent_Identity=38.125, Blast_Score=113, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17509087, Length=175, Percent_Identity=38.8571428571429, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6323619, Length=165, Percent_Identity=36.3636363636364, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320649, Length=157, Percent_Identity=34.3949044585987, Blast_Score=71, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17136334, Length=153, Percent_Identity=44.4444444444444, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19564; Mature: 19432

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFVAVVDAMAEAAEKL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHHHC
NAEIIGGLDARGFLLGSAVAYKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEG
CHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEECCCCCEEEECCCCC
IDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVLAIEVPGLGGRDNLGDRPVIV
CCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEE
VRDPQ
EECCC
>Mature Secondary Structure 
SEQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFVAVVDAMAEAAEKL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHHHC
NAEIIGGLDARGFLLGSAVAYKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEG
CHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEECCCCCEEEECCCCC
IDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVLAIEVPGLGGRDNLGDRPVIV
CCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEE
VRDPQ
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA