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The map label for this gene is rel [H]

Identifier: 62390535

GI number: 62390535

Start: 1754084

End: 1756366

Strand: Reverse

Name: rel [H]

Synonym: cg1861

Alternate gene names: 62390535

Gene position: 1756366-1754084 (Counterclockwise)

Preceding gene: 62390536

Following gene: 62390531

Centisome position: 53.5

GC content: 55.28

Gene sequence:

>2283_bases
ATGAGTCTGGAGCGCAACACACAAAAATCTTCCATGGGTGTGCGAAGCATGTCAGCCAGGCTTGCCCGCAGCCTCACAGG
AAACCGCGTTCGCACCAACCCTGTGCTGGATCCGCTGCTGAGCATCCACCGGCAATTTCACCCACGCGCCGACGTACAAG
TGTTGGAACGTGCATATGACACCGCGGAACGTCTTCATGATGGTGTGATTCGAAAATCGGGCGATCCGTATATTACCCAC
CCGTTGGCTGTCGCCACCATCGCCGCGGAAATCGGCATGGACACCACCACGCTCGTCGCAGCCTTGTTGCATGACACGGT
GGAAGACACCGACTACTCTTTGGACGATCTCACCCGAGATTTCGGAGAAGAAGTTGCCAGGCTTGTCGACGGTGTCACCA
AGCTCGACAAAGTCGCACTAGGTGCTGCCGCGGAGGCCGAAACGATTCGCAAAATGATCGTCGCCATGAGCCAGGACCCC
CGCGTGCTGGTGATTAAAGTGGCCGACCGTTTGCACAATATGCGCACCATGCGGTTCCTGCCGCCGGAAAAGCAAGCTAA
AAAAGCACGCCAAACCCTTGAAGTGATTGCTCCTTTGGCACACCGCCTGGGCATGGCCAGCGTGAAATGGGAATTGGAAG
ATCTATCCTTTGCCATTTTGTACCCCAAGAAGTACGAAGAGATCGTGCGTCTTGTTGCCGACCGCGCGCCCTCTAGAGAC
CGGTACCTCAAAGAAATTATTGATCAAGTCACCGGTGGCTTGCGCGAAAACAACATCGCGGCAGGAGTGCTTGGTCGACC
AAAGCACTACTGGTCTATCTATCAAAAGATGATCGTTCGCGGTCGTGATTTTGACGATATTTTTGATCTTGTTGGCATCC
GCATCCTGGTAGACAACGTGAACAACTGTTACGCCGCCATCGGTGTCGTGCACTCCCTGTTCAATGCTCTGCCTGGCCGA
TTCAAAGACTATATTTCAGCCCCGCGCTTCGGTGTCTACCAATCCCTGCACACCACCGTGATGGGACCTGGCGGTAAGCC
TCTGGAAGTTCAGGCACGTACCCACGACATGCACTACAACGCCGAATTCGGCATTGCAGCGCACTGGCGATACAAAGAAA
CCAAAGGCAGCCACAGTGGCGAGCAAGCCGAAGTGGATCAAATGGCGTGGATGCGCCAACTTCTGGACTGGCAAAAAGAA
GCAGCCGACCCCAACGAGTTCCTGGACAGCCTGCGCTACGATCTGACTTCCAAGCAGATCTTCGTGTTCACACCCAAAGG
TGATGTGGTCAACCTGCCGGTGAACTCCACCCCGGTGGACTTCGCCTACGCGGTGCACACCGAAGTGGGGCACCGCTGCA
TCGGCGCCAAAATCAACGGCAAACTGGTCGCTTTGGAAACGAAACTCAAATCCGGCGATCGTGTTGAAGTCTTTACCTCC
AAGGACCAAAACGCTGGCCCAAGTAGGGGATGGCAAGAATTTGTTGTCTCACCTCGTGCAAAGGCCAAGATTCGCCAGTG
GTTTGCCAAGGAACGACGCGAAGAATACCTAGAAGCCGGACGCGATGCGCTGGCAGCAGTTATTCAGCGTGGCGGCCTGC
CAATGCACCGCTTGTTCACCGCGTCCTCCATGAAGACGGTGGCAACAGAGCTGCACTACCCAGATGTAGATGCGCTCTAC
ACAGCCATCGGCTCCGGTTCTGTATCTGCGCAACACGTAGTCAACCGTCTCATGGCTATCTTTGGTGACGAAGAAGATGC
CGAAGACGCATTGGTTGCACGCACCCCATTCAGCGAGCTGGTCAACTCCCGTGCCACCACGGAAAGCAGCACCGGCATCC
TGGTCGAAGGCAGCCCAGATGTCATGGCTAAGCTCGCTAAATGCTGTATGCCAGTGCCAGGAGATGAAATCTTTGGATTC
GTCACCCGTGGTGGCGGTGTCTCCGTACACCGAACAGACTGCACGAATGTGGAAAAGCTCAAAGAAGAGCCAGAACGCAT
TGTCTCCGTCTCCTGGGCTTCGGAAGGTCAAGGTTCAGTATTCTCTGCCACACTGCAGCTTGAAGCACTTGATCGCGCAG
GCCTGCTCTTTGAGCTCACCCGCGTAATCAACGAACAAAAGGTCTCCGTTACCGCAATGAACTCCCATTGCTCAGAAGAC
CGCGTAGCCACCGTGCGCTTCACCTTTGCGGTCTCTGACACCAAGCAGTTGGGATCCCTGATGACACAGCTGCGCAATGC
CGAAGGAGTGTTTGATGTCTACCGAGTGACCTCGGGTGGCTAG

Upstream 100 bases:

>100_bases
TGAGGTCCCAGGCCTCGGCGGTAGGGATAATCTTGGTGATAGGCCCGTCATTGTGGTCAGAGATCCTCAGTAGAAGGATC
GAAAGAAAGGCGGCAGGAAA

Downstream 100 bases:

>100_bases
AGGCCTTTAGATTGTGAAAAAGCCTTGGGCTTCAACCACCGTGTGTTGACACGGTTTTGGTGTTGGATTTAACGCTGGAA
ATTTTACTGCAATGAACGCT

Product: ppGpp synthetase, ppGpp pyrophosphorylase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITH
PLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDP
RVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
RYLKEIIDQVTGGLRENNIAAGVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGR
FKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKE
AADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALY
TAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGF
VTRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG

Sequences:

>Translated_760_residues
MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITH
PLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDP
RVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
RYLKEIIDQVTGGLRENNIAAGVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGR
FKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKE
AADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALY
TAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGF
VTRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
>Mature_759_residues
SLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITHP
LAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPR
VLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRDR
YLKEIIDQVTGGLRENNIAAGVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGRF
KDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEA
ADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTSK
DQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALYT
AIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFV
TRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSEDR
VATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=135, Percent_Identity=42.2222222222222, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1790082, Length=723, Percent_Identity=38.3125864453665, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1789147, Length=688, Percent_Identity=36.4825581395349, Blast_Score=493, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84376; Mature: 84245

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHH
TAERLHDGVIRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRD
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
FGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEECC
PPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
CCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
RYLKEIIDQVTGGLRENNIAAGVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNV
HHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECC
NNCYAAIGVVHSLFNALPGRFKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYN
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHEECCCCCCEEEEEEECCEEEC
AEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQI
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
EEECCCCCEEECCCCCCCCCEEEEEHHHHCCEEECEEECCEEEEEEEECCCCCEEEEEEC
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFT
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ASSMKTVATELHYPDVDALYTAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSEL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHH
VNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNVEKL
HCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECCCCCHHHH
KEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
HHCHHHEEEEEECCCCCCCEEEEEEEEEHHHHCHHHHHHHHHHCHHHEEEEEECCCCCCC
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
CEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure 
SLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHH
TAERLHDGVIRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRD
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
FGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEECC
PPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
CCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
RYLKEIIDQVTGGLRENNIAAGVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNV
HHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECC
NNCYAAIGVVHSLFNALPGRFKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYN
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHEECCCCCCEEEEEEECCEEEC
AEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQI
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
EEECCCCCEEECCCCCCCCCEEEEEHHHHCCEEECEEECCEEEEEEEECCCCCEEEEEEC
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFT
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ASSMKTVATELHYPDVDALYTAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSEL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHH
VNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNVEKL
HCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECCCCCHHHH
KEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
HHCHHHEEEEEECCCCCCCEEEEEEEEEHHHHCHHHHHHHHHHCHHHEEEEEECCCCCCC
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
CEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9695918; 12948626 [H]