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The map label for this gene is ribA

Identifier: 62390477

GI number: 62390477

Start: 1691825

End: 1693093

Strand: Reverse

Name: ribA

Synonym: cg1798

Alternate gene names: 62390477

Gene position: 1693093-1691825 (Counterclockwise)

Preceding gene: 62390478

Following gene: 62390476

Centisome position: 51.58

GC content: 56.82

Gene sequence:

>1269_bases
GTGAGTGAACATGAGCAGGCACACAGCCAATTAGATTCTGTTGAAGAGGCCATCGCTGACATCGCTGCGGGTAAAGCCGT
CGTGGTGGTAGATGATGAAGATCGTGAAAATGAAGGCGACATCATCTTTGCCGCCGAATTAGCCACTCCAGAATTAGTCG
CTTTCATGGTGCGTTATTCCTCGGGATACATCTGTGCGCCATTAACCGCAAAGGATGCAGATCGTCTTGATCTGCCTCCG
ATGACCGCGCACAATCAGGATGCCCGCGGCACCGCTTACACCGTGACCGTTGATGCCAACACCGGCACCACAGGCATTTC
TGCAACAGACCGCGCCCACACTTTGCGCTTGCTTGCTGATCCAGAAGCCGACCGCACGGATTTCACCCGTCCCGGACACG
TTGTGCCACTGCGTGCTCGTGAAGGTGGCGTCTTGGTGCGCGCTGGACACACCGAAGCAGCTGTCGATTTGGCTCGCGCT
GCAGGCCTGCGCCCAGCAGGTGTTATCTGCGAAGTGGTCAGTGAAGAGGACCCCACCGGCATGGCTCGGGTTCCTGAGCT
GCGCCGCTTCTGCGATGAGCACGATCTGAAGCTGATCTCTATTGAGCAGCTCATTGAGTGGCGTCGCAAGAATGAAATTT
TGGTGGAGCGCCAGGTGGAAACTGTGCTGCCTACCGATTTCGGCACGTTCAAGGCTGTTGGTTACCGTTCCATCATCGAT
GGCACCGAGCTTGTTGCCATTGTTGCCGGCGACGTGGCATCCGACGGTGGCGAAAACGTCCTGGTTCGAGTCCACTCTGA
GTGCTTGACTGGTGATGTTTTTGGATCCCGGCGCTGCGACTGTGGACAGCAGCTGCACGAGTCTTTGCGCCTGATCCAGG
AAGCTGGTCGGGGAGTAGTGGTGTACATGCGTGGGCATGAGGGACGAGGCATTGGTCTGCTCGCCAAGCTACGCGCCTAC
CAACTCCAGGATGAAGGTGCCGACACCGTCGATGCCAACCTCGCACTTGGTCTTCCAGCCGATGCCCGCGAATTTGGCAC
CAGCGCCCAGATTCTCTACGACTTGGGTGTGCGCTCGCTCAACTTGATCAGCAACAACCCAGCCAAGAAGGTGGGACTTG
AAGGCCACGGCATTTCCATTGCCAGCCGAACCCCCATCCCTGTTGCTGTTCATGAAGACAATGTTCGATACCTGAAAACC
AAGCGTGACCGCATGGGACATGACCTCCCAGATGTCGCACTGTGGGAACAAGAGCACCCAGAAAACTAA

Upstream 100 bases:

>100_bases
GATGTGATCGCTAAGTACGTCGAACGCATGATGACGCGCGGCGTGGCTGGAAACACTCCCAATGACTACACCGATTTCAC
GAGAGACTAGGTTAGACAAC

Downstream 100 bases:

>100_bases
GGAGCACAACAATGGCTAAAGAAGGATTGCCGGCAGTCGAACTCCCCGACGCCAGCGGATTAAAAGTCGCCGTAGTCACC
GCACGGTGGAACGCAGAAAT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MSEHEQAHSQLDSVEEAIADIAAGKAVVVVDDEDRENEGDIIFAAELATPELVAFMVRYSSGYICAPLTAKDADRLDLPP
MTAHNQDARGTAYTVTVDANTGTTGISATDRAHTLRLLADPEADRTDFTRPGHVVPLRAREGGVLVRAGHTEAAVDLARA
AGLRPAGVICEVVSEEDPTGMARVPELRRFCDEHDLKLISIEQLIEWRRKNEILVERQVETVLPTDFGTFKAVGYRSIID
GTELVAIVAGDVASDGGENVLVRVHSECLTGDVFGSRRCDCGQQLHESLRLIQEAGRGVVVYMRGHEGRGIGLLAKLRAY
QLQDEGADTVDANLALGLPADAREFGTSAQILYDLGVRSLNLISNNPAKKVGLEGHGISIASRTPIPVAVHEDNVRYLKT
KRDRMGHDLPDVALWEQEHPEN

Sequences:

>Translated_422_residues
MSEHEQAHSQLDSVEEAIADIAAGKAVVVVDDEDRENEGDIIFAAELATPELVAFMVRYSSGYICAPLTAKDADRLDLPP
MTAHNQDARGTAYTVTVDANTGTTGISATDRAHTLRLLADPEADRTDFTRPGHVVPLRAREGGVLVRAGHTEAAVDLARA
AGLRPAGVICEVVSEEDPTGMARVPELRRFCDEHDLKLISIEQLIEWRRKNEILVERQVETVLPTDFGTFKAVGYRSIID
GTELVAIVAGDVASDGGENVLVRVHSECLTGDVFGSRRCDCGQQLHESLRLIQEAGRGVVVYMRGHEGRGIGLLAKLRAY
QLQDEGADTVDANLALGLPADAREFGTSAQILYDLGVRSLNLISNNPAKKVGLEGHGISIASRTPIPVAVHEDNVRYLKT
KRDRMGHDLPDVALWEQEHPEN
>Mature_421_residues
SEHEQAHSQLDSVEEAIADIAAGKAVVVVDDEDRENEGDIIFAAELATPELVAFMVRYSSGYICAPLTAKDADRLDLPPM
TAHNQDARGTAYTVTVDANTGTTGISATDRAHTLRLLADPEADRTDFTRPGHVVPLRAREGGVLVRAGHTEAAVDLARAA
GLRPAGVICEVVSEEDPTGMARVPELRRFCDEHDLKLISIEQLIEWRRKNEILVERQVETVLPTDFGTFKAVGYRSIIDG
TELVAIVAGDVASDGGENVLVRVHSECLTGDVFGSRRCDCGQQLHESLRLIQEAGRGVVVYMRGHEGRGIGLLAKLRAYQ
LQDEGADTVDANLALGLPADAREFGTSAQILYDLGVRSLNLISNNPAKKVGLEGHGISIASRTPIPVAVHEDNVRYLKTK
RDRMGHDLPDVALWEQEHPEN

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1789420, Length=205, Percent_Identity=47.3170731707317, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=48.7179487179487, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=48.0392156862745, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6319438, Length=190, Percent_Identity=43.6842105263158, Blast_Score=126, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBBA_CORGB (A4QEG9)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138537.1
- ProteinModelPortal:   A4QEG9
- STRING:   A4QEG9
- GeneID:   4992851
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1643
- eggNOG:   COG0108
- HOGENOM:   HBG735778
- OMA:   RCDCRMQ
- ProtClustDB:   PRK09311
- HAMAP:   MF_01283
- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299
- Gene3D:   G3DSA:3.90.870.10
- PIRSF:   PIRSF001259
- TIGRFAMs:   TIGR00505
- TIGRFAMs:   TIGR00506

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2; SSF55821 DHBP_synth_RibB-like_a/b_dom

EC number: =4.1.99.12; =3.5.4.25

Molecular weight: Translated: 45825; Mature: 45694

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: ACT_SITE 341-341 ACT_SITE 343-343 BINDING 40-40 BINDING 171-171 BINDING 284-284 BINDING 329-329 BINDING 364-364 BINDING 369-369

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHEQAHSQLDSVEEAIADIAAGKAVVVVDDEDRENEGDIIFAAELATPELVAFMVRYS
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHC
SGYICAPLTAKDADRLDLPPMTAHNQDARGTAYTVTVDANTGTTGISATDRAHTLRLLAD
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEC
PEADRTDFTRPGHVVPLRAREGGVLVRAGHTEAAVDLARAAGLRPAGVICEVVSEEDPTG
CCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCHHHHEEEECCCCCCC
MARVPELRRFCDEHDLKLISIEQLIEWRRKNEILVERQVETVLPTDFGTFKAVGYRSIID
CHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHCCHHHHCC
GTELVAIVAGDVASDGGENVLVRVHSECLTGDVFGSRRCDCGQQLHESLRLIQEAGRGVV
CCEEEEEEECCCCCCCCCEEEEEEECHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEE
VYMRGHEGRGIGLLAKLRAYQLQDEGADTVDANLALGLPADAREFGTSAQILYDLGVRSL
EEEECCCCCCCHHHHHHHHHHCCCCCCCEECCEEEECCCCCHHHHCCCCEEEECCCCCEE
NLISNNPAKKVGLEGHGISIASRTPIPVAVHEDNVRYLKTKRDRMGHDLPDVALWEQEHP
EEECCCCHHHCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCC
EN
CC
>Mature Secondary Structure 
SEHEQAHSQLDSVEEAIADIAAGKAVVVVDDEDRENEGDIIFAAELATPELVAFMVRYS
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHC
SGYICAPLTAKDADRLDLPPMTAHNQDARGTAYTVTVDANTGTTGISATDRAHTLRLLAD
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEC
PEADRTDFTRPGHVVPLRAREGGVLVRAGHTEAAVDLARAAGLRPAGVICEVVSEEDPTG
CCCCCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCHHHHEEEECCCCCCC
MARVPELRRFCDEHDLKLISIEQLIEWRRKNEILVERQVETVLPTDFGTFKAVGYRSIID
CHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHCCHHHHCC
GTELVAIVAGDVASDGGENVLVRVHSECLTGDVFGSRRCDCGQQLHESLRLIQEAGRGVV
CCEEEEEEECCCCCCCCCEEEEEEECHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEE
VYMRGHEGRGIGLLAKLRAYQLQDEGADTVDANLALGLPADAREFGTSAQILYDLGVRSL
EEEECCCCCCCHHHHHHHHHHCCCCCCCEECCEEEECCCCCHHHHCCCCEEEECCCCCEE
NLISNNPAKKVGLEGHGISIASRTPIPVAVHEDNVRYLKTKRDRMGHDLPDVALWEQEHP
EEECCCCHHHCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCC
EN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA